NANOPARTICLE-BASED formulation of dihydroartemisinin-lumefantrine duo-drugs: Preclinical Evaluation and enhanced antimalarial efficacy in a mouse model

Autor: Odera, Pesila Akeyo, Otieno, Geoffrey, Onyango, Joab Otieno, Owuor, James Jorum, Oloo, Florence Anyango, Ongas, Martin, Gathirwa, Jeremiah, Ogutu, Bernhards

Publikováno v: In Heliyon 30 March 2024 10(6)

Ganaplacide (KAF156) plus lumefantrine solid dispersion formulation combination for uncomplicated Plasmodium falciparum malaria: an open-label, multicentre, parallel-group, randomised, controlled, phase 2 trial

Autor: Ogutu, Bernhards, Yeka, Adoke, Kusemererwa, Sylvia, Thompson, Ricardo ^*, Tinto, Halidou, Toure, Andre Offianan, Uthaisin, Chirapong, Verma, Amar, Kibuuka, Afizi, Lingani, Moussa, Lourenço, Carlos, Mombo-Ngoma, Ghyslain, Nduba, Videlis, N'Guessan, Tiacoh Landry, Nassa, Guétawendé Job Wilfried, Nyantaro, Mary, Tina, Lucas Otieno, Singh, Piyoosh K, El Gaaloul, Myriam, Marrast, Anne Claire, Chikoto, Havana, Csermak, Katalin, Demin, Ivan, Mehta, Dheeraj, Pathan, Rashidkhan, Risterucci, Celine, Su, Guoqin, Winnips, Cornelis, Kaguthi, Grace, Fofana, Bakary, Grobusch, Martin Peter ^*

Publikováno v: In The Lancet Infectious Diseases September 2023 23(9):1051-1061

Efficacy, safety, and palatability of arpraziquantel (L-praziquantel) orodispersible tablets in children aged 3 months to 6 years infected with Schistosoma in Côte d'Ivoire and Kenya: an open-label, partly randomised, phase 3 trial

Autor: N'Goran, Eliézer K ^*, Odiere, Maurice R ^*, Assandé Aka, Ronald, Ouattara, Mamadou, Aka, N A David, Ogutu, Bernhards, Rawago, Fredrick, Bagchus, Wilhelmina M, Bödding, Matthias, Kourany-Lefoll, Elly, Tappert, Aliona, Yin, Xiaoyan, Bezuidenhout, Deon, Badenhorst, Henk, Huber, Eric, Dälken, Benjamin ^*, Haj-Ali Saflo, Okba

Publikováno v: In The Lancet Infectious Diseases July 2023 23(7):867-876

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Pharmacokinetics of Ganaplacide and Lumefantrine in Adults, Adolescents, and Children with Plasmodium falciparum Malaria Treated with Ganaplacide Plus Lumefantrine Solid Dispersion Formulation: Analysis of Data from a Multinational Phase 2 Study.

Autor: Sangana, Ramachandra¹ (AUTHOR) ramachandra.sangana@novartis.com, Ogutu, Bernhards² (AUTHOR), Yeka, Adoke³ (AUTHOR), Kusemererwa, Sylvia⁴ (AUTHOR), Tinto, Halidou⁵ (AUTHOR), Toure, Andre Offianan⁶ (AUTHOR), Kibuuka, Afizi⁷ (AUTHOR), Lingani, Moussa⁵ (AUTHOR), Lourenço, Carlos⁸ (AUTHOR), Mombo‐Ngoma, Ghyslain^9,10 (AUTHOR), Nduba, Videlis¹¹ (AUTHOR), Landry N'Guessan, Tiacoh⁶ (AUTHOR), Nassa, Guétawendé Job Wilfried⁵ (AUTHOR), Nyantaro, Mary⁴ (AUTHOR), Tina, Lucas Otieno¹² (AUTHOR), Anvikar, Anup¹³ (AUTHOR), Sinha, Abhinav¹³ (AUTHOR), Kaguthi, Grace¹¹ (AUTHOR), Fofana, Bakary¹⁴ (AUTHOR), Grobusch, Martin Peter^9,15,16 (AUTHOR)

Publikováno v: Journal of Clinical Pharmacology. Sep2024, p1. 11p. 1 Illustration.