A monoclonal antibody targeting the Nipah virus fusion glycoprotein apex imparts protection from disease.

Autor: Avanzato VA; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Bushmaker T; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA., Oguntuyo KY; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Yinda CK; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA., Duyvesteyn HME; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Stass R; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Meade-White K; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA., Rosenke R; Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA., Thomas T; Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA., van Doremalen N; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA., Saturday G; Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA., Doores KJ; Department of Infectious Diseases, King's College London, Guy's Hospital, London, United Kingdom., Lee B; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Bowden TA; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Munster VJ; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.

Publikováno v: Journal of virology [J Virol] 2024 Oct 22; Vol. 98 (10), pp. e0063824. Date of Electronic Publication: 2024 Sep 06.

Structure guided mutagenesis of Henipavirus Receptor Binding Proteins reveals molecular determinants of receptor usage and antibody binding epitopes.

Autor: Oguntuyo KY; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Haas GD; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Azarm KD; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Stevens CS; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Brambilla L; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kowdle S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Avanzato VA; Division of Structural Biology, Wellcome Center for Human Genetics, University of Oxford, OX3 7BN Oxford, United Kingdom., Pryce R; Division of Structural Biology, Wellcome Center for Human Genetics, University of Oxford, OX3 7BN Oxford, United Kingdom., Freiberg AN; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA., Bowden TA; Division of Structural Biology, Wellcome Center for Human Genetics, University of Oxford, OX3 7BN Oxford, United Kingdom., Lee B; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 22. Date of Electronic Publication: 2023 Nov 22.

Metagenomics-enabled reverse-genetics assembly and characterization of myotis bat morbillivirus.

Autor: Ikegame S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Carmichael JC; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wells H; Department of Ecology, Evolution and Environmental Biology, Columbia University, New York, NY, USA., Furler O'Brien RL; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, USA., Acklin JA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Chiu HP; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Oguntuyo KY; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cox RM; Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA., Patel AR; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kowdle S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Stevens CS; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Eckley M; Center for Vector-borne Infectious Diseases Department of Microbiology, Immunology and Pathology College of Veterinary Medicine Colorado State University, Fort Collins, CO, USA., Zhan S; Center for Vector-borne Infectious Diseases Department of Microbiology, Immunology and Pathology College of Veterinary Medicine Colorado State University, Fort Collins, CO, USA., Lim JK; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Veit EC; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Evans MJ; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hashiguchi T; Laboratory of Medical Virology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., Durigon E; Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil., Schountz T; Center for Vector-borne Infectious Diseases Department of Microbiology, Immunology and Pathology College of Veterinary Medicine Colorado State University, Fort Collins, CO, USA., Epstein JH; EcoHealth Alliance, New York, NY, USA., Plemper RK; Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA., Daszak P; EcoHealth Alliance, New York, NY, USA., Anthony SJ; Department of Pathology, Microbiology, and Immunology, UC Davis School of Veterinary Medicine, Davis, CA, USA., Lee B; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. benhur.lee@mssm.edu.

Publikováno v: Nature microbiology [Nat Microbiol] 2023 Jun; Vol. 8 (6), pp. 1108-1122. Date of Electronic Publication: 2023 May 04.

Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients.

Autor: Klingler J; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; James J. Peters VA Medical Center, Bronx, NY, USA., Lambert GS; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bandres JC; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; James J. Peters VA Medical Center, Bronx, NY, USA., Emami-Gorizi R; James J. Peters VA Medical Center, Bronx, NY, USA., Nádas A; Department of Environment Medicine, NYU School of Medicine, New York, NY, USA., Oguntuyo KY; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Amanat F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bermúdez-González MC; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gleason C; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kleiner G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Simon V; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lee B; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Zolla-Pazner S; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Upadhyay C; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hioe CE; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; James J. Peters VA Medical Center, Bronx, NY, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Publikováno v: IScience [iScience] 2022 Dec 22; Vol. 25 (12), pp. 105608. Date of Electronic Publication: 2022 Nov 16.

The IgA in milk induced by SARS-CoV-2 infection is comprised of mainly secretory antibody that is neutralizing and highly durable over time.

Autor: Fox A; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Marino J; Health Sciences Research Institute, University of California Merced, Merced, California, United States of America.; Department of Psychology, University of California Merced, Merced, California, United States of America., Amanat F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Oguntuyo KY; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Hahn-Holbrook J; Health Sciences Research Institute, University of California Merced, Merced, California, United States of America.; Department of Psychology, University of California Merced, Merced, California, United States of America., Lee B; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Zolla-Pazner S; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Powell RL; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

Publikováno v: PloS one [PLoS One] 2022 Mar 09; Vol. 17 (3), pp. e0249723. Date of Electronic Publication: 2022 Mar 09 (Print Publication: 2022).