Lorcaserin improves glycemic control via a melanocortin neurocircuit

Autor: Burke L. K., Ogunnowo-Bada E., Georgescu T., Cristiano C., de Morentin P. B. M., Valencia Torres L., D'Agostino G., Riches C., Heeley N., Ruan Y., Rubinstein M., Low M. J., Myers M. G., Rochford J. J., Evans M. L., Heisler L. K.

Objective: The increasing prevalence of type 2 diabetes (T2D) and associated morbidity and mortality emphasizes the need for a more complete understanding of the mechanisms mediating glucose homeostasis to accelerate the identification of new medicat

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http://hdl.handle.net/11588/838231

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Lorcaserin improves glycemic control via a melanocortin neurocircuit.

Autor: Burke LK; Department of Pharmacology, University of Cambridge, Cambridge, UK; Department of Medicine and Wellcome Trust/MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Ogunnowo-Bada E; Department of Medicine and Wellcome Trust/MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Georgescu T; The Rowett Institute, University of Aberdeen, Aberdeen, UK., Cristiano C; The Rowett Institute, University of Aberdeen, Aberdeen, UK., de Morentin PBM; The Rowett Institute, University of Aberdeen, Aberdeen, UK., Valencia Torres L; Department of Pharmacology, University of Cambridge, Cambridge, UK; The Rowett Institute, University of Aberdeen, Aberdeen, UK., D'Agostino G; Department of Pharmacology, University of Cambridge, Cambridge, UK; The Rowett Institute, University of Aberdeen, Aberdeen, UK., Riches C; Department of Medicine and Wellcome Trust/MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Heeley N; Department of Medicine and Wellcome Trust/MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Ruan Y; Department of Medicine and Wellcome Trust/MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Rubinstein M; Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, 1428 Buenos Aires, Argentina., Low MJ; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Myers MG; Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA., Rochford JJ; The Rowett Institute, University of Aberdeen, Aberdeen, UK., Evans ML; Department of Medicine and Wellcome Trust/MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK. Electronic address: mle24@cam.ac.uk., Heisler LK; Department of Pharmacology, University of Cambridge, Cambridge, UK; The Rowett Institute, University of Aberdeen, Aberdeen, UK. Electronic address: lora.heisler@abdn.ac.uk.

Publikováno v: Molecular metabolism [Mol Metab] 2017 Oct; Vol. 6 (10), pp. 1092-1102. Date of Electronic Publication: 2017 Jul 21.

Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons.

Autor: Burke LK; Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK; Department of Medicine and Institute of Metabolic Science, University of Cambridge, Wellcome Trust/Medical Research Council, Cambridge, UK; Department of Pharmacology, University of Cambridge, Cambridge, UK., Doslikova B; Department of Pharmacology, University of Cambridge, Cambridge, UK., D'Agostino G; Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK; Department of Pharmacology, University of Cambridge, Cambridge, UK., Greenwald-Yarnell M; Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA., Georgescu T; Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK., Chianese R; Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK., Martinez de Morentin PB; Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK., Ogunnowo-Bada E; Department of Medicine and Institute of Metabolic Science, University of Cambridge, Wellcome Trust/Medical Research Council, Cambridge, UK., Cansell C; Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK., Valencia-Torres L; Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK; Department of Pharmacology, University of Cambridge, Cambridge, UK., Garfield AS; Department of Pharmacology, University of Cambridge, Cambridge, UK., Apergis-Schoute J; Department of Pharmacology, University of Cambridge, Cambridge, UK., Lam DD; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Speakman JR; Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China., Rubinstein M; Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, 1428, Buenos Aires, Argentina., Low MJ; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Rochford JJ; Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK., Myers MG; Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA., Evans ML; Department of Medicine and Institute of Metabolic Science, University of Cambridge, Wellcome Trust/Medical Research Council, Cambridge, UK. Electronic address: mle24@cam.ac.uk., Heisler LK; Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK. Electronic address: lora.heisler@abdn.ac.uk.

Publikováno v: Molecular metabolism [Mol Metab] 2016 Jan 22; Vol. 5 (3), pp. 245-252. Date of Electronic Publication: 2016 Jan 22 (Print Publication: 2016).

Unraveling the serotonin saga: from discovery to weight regulation and beyond - a comprehensive scientific review.

Autor: Conde, Kristine¹ (AUTHOR) Kristine.conde@bcm.edu, Fang, Shuzheng² (AUTHOR), Xu, Yong^1,3,4 (AUTHOR) yongx@bcm.edu

Publikováno v: Cell & Bioscience. 8/7/2023, Vol. 13 Issue 1, p1-11. 11p.