Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Ognian C Ikonomov"'
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204532 (2018)
PIKfyve, an evolutionarily conserved kinase synthesizing PtdIns5P and PtdIns(3,5)P2, is crucial for mammalian cell proliferation and viability. Accordingly, PIKfyve inhibitors are now in clinical trials as anti-cancer drugs. Among those, apilimod is
Externí odkaz:
https://doaj.org/article/8ff7ec8dfdaa44b1b82f0c9ffb9cf59b
Publikováno v:
Biological Rhythm Research. 53:1226-1243
The role of suprachiasmatic nuclei (SCN) in the anterior hypothalamus as a master ~24 h oscillator (clock) and synchronizer of the circadian regulatory system is reviewed extensively. In contrast, ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6d3bdfc653ea3463cb027f510643c41
https://doi.org/10.1080/09291016.2021.1920125
https://doi.org/10.1080/09291016.2021.1920125
Autor:
Ognian C. Ikonomov, Michele H. Jacob
Publikováno v:
BioTechniques, Vol 20, Iss 6, Pp 1030-1042 (1996)
A modified reverse transcription polymerase chain reaction (RT-PCR)-based differential display procedure with selected primers (SPR) was developed to increase the bias toward isolating moderate- to low-abundance transcripts that are differentially ex
Externí odkaz:
https://doaj.org/article/0869ec1a47124448b544d466da0d5e5b
Publikováno v:
Toxicology and Applied Pharmacology. 356:151-158
PIKfyve phosphoinositide kinase produces PtdIns(3,5)P2 and PtdIns5P and governs a myriad of cellular processes including cytoskeleton rearrangements and cell proliferation. The latter entails rigorous investigation since the cytotoxicity of PIKfyve i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78745d6a99124325138045de2481ad06
https://doi.org/10.1016/j.taap.2018.08.001
https://doi.org/10.1016/j.taap.2018.08.001
Autor:
Xuequn Chen, Lauren M. Compton, Ellen J. Tisdale, Ognian C. Ikonomov, Assia Shisheva, Diego Sbrissa, Rita Kumar
Publikováno v:
Journal of Biological Chemistry. 290:28515-28529
The 5-phosphoinositide phosphatase Sac3, in which loss-of-function mutations are linked to neurodegenerative disorders, forms a stable cytosolic complex with the scaffolding protein ArPIKfyve. The ArPIKfyve-Sac3 heterodimer interacts with the phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c3cc8125dfe7e78cedf357675507f1
https://doi.org/10.1074/jbc.m115.669929
https://doi.org/10.1074/jbc.m115.669929
Publikováno v:
BioEssays. 37:267-277
Recently, we have presented data supporting the notion that PIKfyve not only produces the majority of constitutive phosphatidylinositol 5-phosphate (PtdIns5P) in mammalian cells but that it does so through direct synthesis from PtdIns. Another group,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45a0436d8c9c5d68d1eefe4e6f380944
https://doi.org/10.1002/bies.201400129
https://doi.org/10.1002/bies.201400129
Autor:
Cristiana F. Pires, Mafalda Lopes da Silva, Laura Cabrita-Santos, Assia Shisheva, Miguel C. Seabra, Ognian C. Ikonomov, Elsa Seixas, Duarte C. Barral, José S. Ramalho, Carolina Thieleke-Matos
Publikováno v:
Traffic. 15:1066-1082
Malaria parasites go through an obligatory liver stage before they infect erythrocytes and cause disease symptoms. In the host hepatocytes, the parasite is enclosed by a parasitophorous vacuole membrane (PVM). Here, we dissected the interaction betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b8e88b5fdbe173a84e88d70e4f89a8
https://doi.org/10.1111/tra.12190
https://doi.org/10.1111/tra.12190
Publikováno v:
Toxicology and Applied Pharmacology. 383:114771
Through synthesis of two rare phosphoinositides, PtdIns(3,5)P2 and PtdIns5P, the ubiquitously expressed phosphoinositide kinase PIKfyve is implicated in pleiotropic cellular functions. Small molecules specifically inhibiting PIKfyve activity cause cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd53e51754d66273ce4d855a871a704
https://doi.org/10.1016/j.taap.2019.114771
https://doi.org/10.1016/j.taap.2019.114771
Publikováno v:
Biochemical and Biophysical Research Communications. 440:342-347
The phosphoinositide 5-kinase PIKfyve and 5-phosphatase Sac3 are scaffolded by ArPIKfyve in the PIKfyve-ArPIKfyve-Sac3 (PAS) regulatory complex to trigger a unique loop of PtdIns3P – PtdIns(3,5)P2 synthesis and turnover. Whereas the metabolizing en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5a53a2ba43f1bede3f1aed9edf86dc
https://doi.org/10.1016/j.bbrc.2013.09.080
https://doi.org/10.1016/j.bbrc.2013.09.080