Computational Evaluation of Azadirachta indica-Derived Bioactive Compounds as Potential Inhibitors of NLRP3 in the Treatment of Alzheimer's Disease.

Autor: Ishabiyi FO; Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.; Institute of Bioinformatics and Molecular Therapeutics, Oshogbo, Osun State, Nigeria., Ogidi JO; Faculty of Pharmacy, University of Nigeria, Nsukka, Enugu, Nigeria.; Institute of Bioinformatics and Molecular Therapeutics, Oshogbo, Osun State, Nigeria., Olukade BA; Physiology Department, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Sagamu Campus, Nigeria.; Institute of Bioinformatics and Molecular Therapeutics, Oshogbo, Osun State, Nigeria., Amorha CC; Department of Biochemistry, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria.; Institute of Bioinformatics and Molecular Therapeutics, Oshogbo, Osun State, Nigeria., El-Sharkawy LY; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, United Kingdom.; Institute of Bioinformatics and Molecular Therapeutics, Oshogbo, Osun State, Nigeria., Okolo CC; Department of Veterinary Medicine University of Nigeria, Nsukka, Nigeria.; Institute of Bioinformatics and Molecular Therapeutics, Oshogbo, Osun State, Nigeria., Adeniyi TM; Department of Biochemistry, Adekunle Ajasin University, Akungba Akoko, Ondo State, Nigeria.; Institute of Bioinformatics and Molecular Therapeutics, Oshogbo, Osun State, Nigeria., Atasie NH; Nigerian Correctional Services, Enugu Custodial Center, Enugu State, Nigeria.; Institute of Bioinformatics and Molecular Therapeutics, Oshogbo, Osun State, Nigeria., Ibrahim A; Department of Biochemistry, Drosophila Laboratory, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria.; Institute of Bioinformatics and Molecular Therapeutics, Oshogbo, Osun State, Nigeria., Balogun TA; Institute of Bioinformatics and Molecular Therapeutics, Oshogbo, Osun State, Nigeria.

Publikováno v: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2023; Vol. 94 (s1), pp. S67-S85.