Co-administration of metformin and/or glibenclamide with losartan reverse N ^G -nitro-l-arginine-methyl ester-streptozotocin-induced hypertensive diabetes and haemodynamic sequelae in rats.

Autor: Moke EG; Department of Pharmacology, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeria; Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria., Omogbai EKI; Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria., Osagie-Eweka SDE; Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin City, Nigeria., Uchendu AP; Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria., Omogbiya AI; Department of Pharmacology, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeria., Ben-Azu B; Department of Pharmacology, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeria. Electronic address: bben-azu@delsu.edu.ng., Eduviere AT; Department of Pharmacology, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeria., Edje KE; Department of Pharmacology, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeria., Umukoro EK; Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, Delta State University, Abraka, Nigeria., Anachuna KK; Department of Physiology, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeria., Asiwe JN; Department of Physiology, Faculty of Basic Medical Sciences, PAMO University of Medical Sciences, Port Harcourt, Nigeria., Ahante E; Department of Pharmacology, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeria., Oghoghovwe IJ; Department of Pharmacology, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeria.

Publikováno v: Microvascular research [Microvasc Res] 2023 May; Vol. 147, pp. 104497. Date of Electronic Publication: 2023 Feb 03.