Human nucleolar protein 7 (NOL7) is required for early pre-rRNA accumulation and pre-18S rRNA processing.

Autor: McCool MA; Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, CT, USA., Bryant CJ; Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, CT, USA., Huang H; Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, CT, USA., Ogawa LM; Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, CT, USA., Farley-Barnes KI; Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, CT, USA., Sondalle SB; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA., Abriola L; Yale Center for Molecular Discovery, Yale University, West Haven, CT, USA., Surovtseva YV; Yale Center for Molecular Discovery, Yale University, West Haven, CT, USA., Baserga SJ; Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, CT, USA.; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.; Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA.

Publikováno v: RNA biology [RNA Biol] 2023 Jan; Vol. 20 (1), pp. 257-271.

Increased numbers of nucleoli in a genome-wide RNAi screen reveal proteins that link the cell cycle to RNA polymerase I transcription.

Autor: Ogawa LM; Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, CT 06520., Buhagiar AF; Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, CT 06520., Abriola L; Yale Center for Molecular Discovery, Yale University, West Haven, CT 06516., Leland BA; Yale Center for Molecular Discovery, Yale University, West Haven, CT 06516., Surovtseva YV; Yale Center for Molecular Discovery, Yale University, West Haven, CT 06516., Baserga SJ; Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, CT 06520.; Department of Genetics, Yale University School of Medicine, New Haven, CT 06520.; Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520.

Publikováno v: Molecular biology of the cell [Mol Biol Cell] 2021 Apr 19; Vol. 32 (9), pp. 956-973. Date of Electronic Publication: 2021 Mar 10.

Identification and biochemical analyses of selective CB 2 agonists.

Autor: Scott CE; Department of Pharmaceutical Sciences, University of Connecticut, 69 N Eagleville Rd, Storrs, CT, 06269, USA., Tang Y; Department of Pharmaceutical Sciences, University of Connecticut, 69 N Eagleville Rd, Storrs, CT, 06269, USA., Alt A; Bristol-Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, CT, 06492, USA., Burford NT; Bristol-Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, CT, 06492, USA., Gerritz SW; Bristol-Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, CT, 06492, USA., Ogawa LM; Bristol-Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, CT, 06492, USA., Zhang L; Bristol-Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, CT, 06492, USA., Kendall DA; Department of Pharmaceutical Sciences, University of Connecticut, 69 N Eagleville Rd, Storrs, CT, 06269, USA. Electronic address: debra.kendall@uconn.edu.

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2019 Jul 05; Vol. 854, pp. 1-8. Date of Electronic Publication: 2019 Apr 03.

Discovery of Selective Cannabinoid CB 2 Receptor Agonists by High-Throughput Screening.

Autor: Ogawa LM; 1 Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT, USA., Burford NT; 2 Bristol-Myers Squibb, Research and Development, Wallingford, CT, USA., Liao YH; 3 Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA., Scott CE; 3 Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA., Hine AM; 3 Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA., Dowling C; 2 Bristol-Myers Squibb, Research and Development, Wallingford, CT, USA., Chin J; 2 Bristol-Myers Squibb, Research and Development, Wallingford, CT, USA., Power M; 2 Bristol-Myers Squibb, Research and Development, Wallingford, CT, USA., Hunnicutt EJ Jr; 2 Bristol-Myers Squibb, Research and Development, Wallingford, CT, USA., Emerick VL; 2 Bristol-Myers Squibb, Research and Development, Wallingford, CT, USA., Banks M; 2 Bristol-Myers Squibb, Research and Development, Wallingford, CT, USA., Zhang L; 2 Bristol-Myers Squibb, Research and Development, Wallingford, CT, USA., Gerritz SW; 2 Bristol-Myers Squibb, Research and Development, Wallingford, CT, USA., Alt A; 2 Bristol-Myers Squibb, Research and Development, Wallingford, CT, USA., Kendall DA; 3 Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA.

Publikováno v: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2018 Apr; Vol. 23 (4), pp. 375-383. Date of Electronic Publication: 2017 Dec 19.

Diverse Regulators of Human Ribosome Biogenesis Discovered by Changes in Nucleolar Number.

Autor: Farley-Barnes KI; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA., McCann KL; Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA; Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, NIH, PO Box 12233 MD F3-05, Research Triangle Park, NC 27709, USA., Ogawa LM; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA., Merkel J; Yale Center for Molecular Discovery, Yale University, 600 West Campus Drive, West Haven, CT 06516, USA., Surovtseva YV; Yale Center for Molecular Discovery, Yale University, 600 West Campus Drive, West Haven, CT 06516, USA., Baserga SJ; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: susan.baserga@yale.edu.

Publikováno v: Cell reports [Cell Rep] 2018 Feb 13; Vol. 22 (7), pp. 1923-1934.