Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor.

Autor: Yi Kuang, Anna Pyo, Natanel Eafergan, Brittany Cain, Lisa M Gutzwiller, Ofri Axelrod, Ellen K Gagliani, Matthew T Weirauch, Raphael Kopan, Rhett A Kovall, David Sprinzak, Brian Gebelein

Publikováno v: PLoS Genetics, Vol 17, Iss 9, p e1009039 (2021)

Notch signaling controls many developmental processes by regulating gene expression. Notch-dependent enhancers recruit activation complexes consisting of the Notch intracellular domain, the Cbf/Su(H)/Lag1 (CSL) transcription factor (TF), and the Mast

Externí odkaz: https://doaj.org/article/46e826c091ea4d9db920f08826b85963

Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor.

Autor: Kuang, Yi¹ (AUTHOR), Pyo, Anna² (AUTHOR), Eafergan, Natanel³ (AUTHOR), Cain, Brittany² (AUTHOR), Gutzwiller, Lisa M.⁴ (AUTHOR), Axelrod, Ofri³ (AUTHOR), Gagliani, Ellen K.⁵ (AUTHOR), Weirauch, Matthew T.^6,7 (AUTHOR), Kopan, Raphael^4,7 (AUTHOR), Kovall, Rhett A.⁵ (AUTHOR), Sprinzak, David³ (AUTHOR), Gebelein, Brian^4,7 (AUTHOR) Brian.Gebelein@cchmc.org

Publikováno v: PLoS Genetics. 9/24/2021, Vol. 17 Issue 9, p1-26. 26p.