Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Ofir, Harari"'
The importance of appropriate selection of clinical endpoints in outpatient COVID-19 clinical trials
Autor:
Kristian Thorlund, Davey Smith, Christopher Linsell, Nicholas White, Christopher Butler, David Boulware, Judith Currier, Ofir Harari, Edouard Lhomme, Nathalie Strub-Wourgaft, Stacey Adam, Edward Mills
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-5 (2023)
Abstract Clinical trial endpoints must be carefully and intentionally selected so that the results of the trial can be used to inform policy- and decision-making. The relative importance of potential endpoints often depends on the stakeholder, with p
Externí odkaz:
https://doaj.org/article/66d021901bcc41f9a3dde635bf62b6b8
Autor:
Bart Heeg, Andre Verhoek, Gabriel Tremblay, Ofir Harari, Mohsen Soltanifar, Haitao Chu, Satrajit Roychoudhury, Joseph C Cappelleri
Publikováno v:
Journal of Comparative Effectiveness Research, Vol 12, Iss 3 (2023)
Aim: This research evaluated standard Weibull mixture cure (WMC) network meta-analysis (NMA) with Bayesian hierarchical (BH)WMCNMAto inform long-term survival of therapies. Materials & methods: Four trials in previously treated metastatic non-small
Externí odkaz:
https://doaj.org/article/bda791ab4a2a40429f0b41dea9350d65
Publikováno v:
Water, Vol 15, Iss 4, p 700 (2023)
Rainfall in Guanacaste, Costa Rica, has marked wet/dry phases: the rainy season is punctuated by a short midsummer drought, and the dry season frequently has months of no rain. In this region, spring and summer rainfall peaks are important for local
Externí odkaz:
https://doaj.org/article/1de605278a4544f5af48a2305eb3d8a5
Autor:
Gilmar Reis, Eduardo Augusto dos Santos Moreira Silva, Daniela Carla Medeiros Silva, Lehana Thabane, Aline Cruz Milagres, Thiago Santiago Ferreira, Castilho Vitor Quirino dos Santos, Adhemar Dias de Figueiredo Neto, Eduardo Diniz Callegari, Leonardo Cançado Monteiro Savassi, Maria Izabel Campos Simplicio, Luciene Barra Ribeiro, Rosemary Oliveira, Ofir Harari, Holly Bailey, Jamie I Forrest, Alla Glushchenko, Sheila Sprague, Paula McKay, Craig R. Rayner, Hinda Ruton, Gordon H. Guyatt, Edward J. Mills
Publikováno v:
The Lancet Regional Health. Americas, Vol 6, Iss , Pp 100142- (2022)
Summary: Background: Observational studies have postulated a therapeutic role of metformin in treating COVID-19. We conducted an adaptive platform clinical trial to determine whether metformin is an effective treatment for high-risk patients with ear
Externí odkaz:
https://doaj.org/article/c787b7addd6647dbaccfffc94732bfc7
Autor:
Gilmar Reis, PhD, Eduardo Augusto dos Santos Moreira-Silva, PhD, Daniela Carla Medeiros Silva, PhD, Lehana Thabane, ProfPhD, Aline Cruz Milagres, RN, Thiago Santiago Ferreira, MD, Castilho Vitor Quirino dos Santos, Vitoria Helena de Souza Campos, Ana Maria Ribeiro Nogueira, MD, Ana Paula Figueiredo Guimaraes de Almeida, MD, Eduardo Diniz Callegari, MD, Adhemar Dias de Figueiredo Neto, PhD, Leonardo Cançado Monteiro Savassi, PhD, Maria Izabel Campos Simplicio, BScPharm, Luciene Barra Ribeiro, RN, Rosemary Oliveira, Ofir Harari, PhD, Jamie I Forrest, MPH, Hinda Ruton, MSc, Sheila Sprague, PhD, Paula McKay, MSc, Alla V Glushchenko, MD, Craig R Rayner, FRCPE, Eric J Lenze, ProfMD, Angela M Reiersen, MD, Gordon H Guyatt, ProfMD, Edward J Mills, ProfFRCP
Publikováno v:
The Lancet Global Health, Vol 10, Iss 1, Pp e42-e51 (2022)
Summary: Background: Recent evidence indicates a potential therapeutic role of fluvoxamine for COVID-19. In the TOGETHER trial for acutely symptomatic patients with COVID-19, we aimed to assess the efficacy of fluvoxamine versus placebo in preventing
Externí odkaz:
https://doaj.org/article/a0e3d44df2b844c5a67fa94c2b64b787
Autor:
Jay J. H Park, Ellie Siden, Michael J. Zoratti, Louis Dron, Ofir Harari, Joel Singer, Richard T. Lester, Kristian Thorlund, Edward J. Mills
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Background Master protocols, classified as basket trials, umbrella trials, and platform trials, are novel designs that investigate multiple hypotheses through concurrent sub-studies (e.g., multiple treatments or populations or that allow add
Externí odkaz:
https://doaj.org/article/0c4a32d79378435db26351cdba94a257
Autor:
Gilmar Reis, Eduardo A.S. Moreira Silva, Daniela C. Medeiros Silva, Lehana Thabane, Vitoria H.S. Campos, Thiago S. Ferreira, Castilho V.Q. Santos, Ana M.R. Nogueira, Ana P.F.G. Almeida, Leonardo C.M. Savassi, Adhemar D. Figueiredo-Neto, Ana C.F. Dias, Adelino M. Freire Júnior, Carina Bitarães, Aline C. Milagres, Eduardo D. Callegari, Maria I.C. Simplicio, Luciene B. Ribeiro, Rosemary Oliveira, Ofir Harari, Lindsay A. Wilson, Jamie I. Forrest, Hinda Ruton, Sheila Sprague, Paula McKay, Christina M. Guo, Eve H. Limbrick-Oldfield, Steve Kanters, Gordon H. Guyatt, Craig R. Rayner, Christopher Kandel, Mia J. Biondi, Robert Kozak, Bettina Hansen, M. Atif Zahoor, Paul Arora, Colin Hislop, Ingrid Choong, Jordan J. Feld, Edward J. Mills, Jeffrey S. Glenn
Publikováno v:
New England Journal of Medicine, 388(6), 518-528. Massachussetts Medical Society
Background: The efficacy of a single dose of pegylated interferon lambda in preventing clinical events among outpatients with acute symptomatic coronavirus disease 2019 (Covid-19) is unclear. Methods: We conducted a randomized, controlled, adaptive p
Autor:
Jay J. H. Park, Ofir Harari, Ellie Siden, Louis Dron, Noor-E Zannat, Joel Singer, Richard T. Lester, Kristian Thorlund, Edward J. Mills
Publikováno v:
Gates Open Research, Vol 3 (2020)
Background: Optimizing linear growth in children during complementary feeding period (CFP) (6-24 months) is critical for their development. Several interventions, such as micronutrient and food supplements, deworming, maternal education, and water, s
Externí odkaz:
https://doaj.org/article/4a71f1dac8a549938e2885b6ff9c240f
Autor:
Jay J. H. Park, Ellie Siden, Ofir Harari, Louis Dron, Reham Mazoub, Virginia Jeziorska, Noor-E Zannat, Heather Gadalla, Kristian Thorlund, Edward J. Mills
Publikováno v:
Gates Open Research, Vol 3 (2020)
Background: Exclusive breastfeeding (EBF) during the first six months of life is critical for child’s linear growth. While there is strong evidence in favor of EBF, the evidence with regards to other interventions for linear growth is unclear. We e
Externí odkaz:
https://doaj.org/article/ca5b0ea411634f9391378fb845dc11ef
Autor:
Jay J. H. Park, Ofir Harari, Ellie Siden, Michael Zoratti, Louis Dron, Noor-E Zannat, Richard T. Lester, Kristian Thorlund, Edward J. Mills
Publikováno v:
Gates Open Research, Vol 3 (2020)
Background: Improving the health of pregnant women is important to prevent adverse birth outcomes, such as preterm birth and low birthweight. We evaluated the comparative effectiveness of interventions under the domains of micronutrient, balanced ene
Externí odkaz:
https://doaj.org/article/3cf1b111584246f2ade4742257a1d67e