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Patient-Specific Vascularized Tumor Model: Blocking TAM Recruitment with Multispecific Antibodies Targeting CCR2 and CSF-1R.

Autor: Nguyen HT; Department of Mechanical Engineering and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA., Gurvich N; Marengo Therapeutics, 840 Memorial Dr, Cambridge, MA 02139 USA., Gillrie MR; Department of Mechanical Engineering and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA.; Department of Medicine, University of Calgary, Calgary, AB, T2N 1N4 Canada., Offeddu G; Department of Mechanical Engineering and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA., Humayun M; Department of Mechanical Engineering and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA., Kan EL; Department of Mechanical Engineering and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA., Wan Z; Department of Mechanical Engineering and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA., Coughlin MF; Department of Mechanical Engineering and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA., Zhang C; Marengo Therapeutics, 840 Memorial Dr, Cambridge, MA 02139 USA., Vu V; Department of Mechanical Engineering and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA., Lee SWL; Department of Mechanical Engineering and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA., Tan SL; Marengo Therapeutics, 840 Memorial Dr, Cambridge, MA 02139 USA., Barbie D; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA.; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA., Hsu J; Marengo Therapeutics, 840 Memorial Dr, Cambridge, MA 02139 USA., Kamm RD; Department of Mechanical Engineering and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 29. Date of Electronic Publication: 2023 Nov 29.