Zobrazeno 1 - 10
of 317
pro vyhledávání: '"Off targets"'
Publikováno v:
The EuroBiotech Journal, Vol 8, Iss 4, Pp 213-229 (2024)
The precise prediction of off-target effects in CRISPR-Cas9 genome editing is critical for ensuring the safety and efficacy of this powerful tool. This study leverages machine learning techniques to predict off-target cleavage sites and investigate t
Externí odkaz:
https://doaj.org/article/e723cd04e3354f1f92a28023e9e5ba80
Publikováno v:
Informatics in Medicine Unlocked, Vol 46, Iss , Pp 101462- (2024)
Acinetobacter baumannii is widely recognized as a human opportunistic pathogen in nosocomial infections. The proliferation of multidrug-resistant strains of A. baumannii has presented an array of difficulties for clinical anti-infective therapies and
Externí odkaz:
https://doaj.org/article/421fb390a3174d44982a573dbfbfb702
Akademický článek
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Autor:
Dawid Głów, Simon Meyer, Irene García Roldán, Lara Marie Akingunsade, Kristoffer Riecken, Boris Fehse
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 249-262 (2021)
Since the introduction of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9), genome editing has been broadly applied in basic research and applied biotechnology, whereas translation into clinical te
Externí odkaz:
https://doaj.org/article/6f33396e84f94dfc9ac886fa0a5d9a8b
Autor:
Petko Alov, Merilin Al Sharif, Denitsa Aluani, Konstantin Chegaev, Jelena Dinic, Aleksandra Divac Rankov, Miguel X. Fernandes, Fabio Fusi, Alfonso T. García-Sosa, Risto Juvonen, Magdalena Kondeva-Burdina, José M. Padrón, Ilza Pajeva, Tania Pencheva, Adrián Puerta, Hannu Raunio, Chiara Riganti, Ivanka Tsakovska, Virginia Tzankova, Yordan Yordanov, Simona Saponara
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Sdox is a hydrogen sulfide (H2S)-releasing doxorubicin effective in P-glycoprotein-overexpressing/doxorubicin-resistant tumor models and not cytotoxic, as the parental drug, in H9c2 cardiomyocytes. The aim of this study was the assessment of Sdox dru
Externí odkaz:
https://doaj.org/article/1c7deddbd8504d1eb6e324f730103fb1
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-12 (2020)
Abstract Background Identifying nuclease-induced double-stranded breaks in DNA on a genome-wide scale is critical for assessing the safety and efficacy of genome editing therapies. We previously demonstrated that after administering adeno-associated
Externí odkaz:
https://doaj.org/article/84dd2ff60759418d8a28d6e3f281d5ef
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Externí odkaz:
https://doaj.org/article/076b838967a14424aecef9eb5a99f030
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
Autor:
Manuel M. Vicente, Miguel Chaves-Ferreira, João M. P. Jorge, João T. Proença, Vasco M. Barreto
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The repurposing of the CRISPR/Cas bacterial defense system against bacteriophages as simple and flexible molecular tools has revolutionized the field of gene editing. These tools are now widely used in basic research and clinical trials involving hum
Externí odkaz:
https://doaj.org/article/1b3a35894b8344bca0790b9767c46967
Publikováno v:
Biomolecules, Vol 12, Iss 8, p 1123 (2022)
The reprogrammable CRISPR/Cas9 genome editing tool’s growing popularity is hindered by unwanted off-target effects. Efforts have been directed toward designing efficient guide RNAs as well as identifying potential off-target threats, yet factors th
Externí odkaz:
https://doaj.org/article/3493fa8fdd5242a8b8db8b1b4c805342