Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Ofer Rog"'
BRCA1/BRC-1 and SMC-5/6 regulate DNA repair pathway engagement during Caenorhabditis elegans meiosis
Autor:
Erik Toraason, Alina Salagean, David E Almanzar, Jordan E Brown, Colette M Richter, Nicole A Kurhanewicz, Ofer Rog, Diana E Libuda
Publikováno v:
eLife, Vol 13 (2024)
The preservation of genome integrity during sperm and egg development is vital for reproductive success. During meiosis, the tumor suppressor BRCA1/BRC-1 and structural maintenance of chromosomes 5/6 (SMC-5/6) complex genetically interact to promote
Externí odkaz:
https://doaj.org/article/5cc501e585fc4bf7b72400fd15e82b53
Autor:
Spencer G Gordon, Ofer Rog
Publikováno v:
PLoS Genetics, Vol 19, Iss 7, p e1010822 (2023)
The successful delivery of genetic material to gametes requires tightly regulated interactions between the parental chromosomes. Central to this regulation is a conserved chromosomal interface called the synaptonemal complex (SC), which brings the pa
Externí odkaz:
https://doaj.org/article/062448e257c440baa6c60dd6d298901d
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101344- (2022)
Summary: Reciprocal exchanges between genetically identical sister chromatids (sister chromatid exchanges or SCEs) have been challenging to study. Here, we describe a protocol that utilizes a pulse/chase of the thymidine analog 5-ethyl-3′-deoxyurid
Externí odkaz:
https://doaj.org/article/73eb4b58d399473ab8ce966840328be0
Publikováno v:
eLife, Vol 10 (2021)
Functional requirements constrain protein evolution, commonly manifesting in a conserved amino acid sequence. Here, we extend this idea to secondary structural features by tracking their conservation in essential meiotic proteins with highly diverged
Externí odkaz:
https://doaj.org/article/bc16d92a8a5a42d0b4692e96904a7b5b
Publikováno v:
PLoS Genetics, Vol 17, Iss 3, p e1009205 (2021)
During sexual reproduction the parental homologous chromosomes find each other (pair) and align along their lengths by integrating local sequence homology with large-scale contiguity, thereby allowing for precise exchange of genetic information. The
Externí odkaz:
https://doaj.org/article/a4d48cfb3dce459a9f18613f216f16e1
Autor:
Ofer Rog, Abby F. Dernburg
Publikováno v:
Cell Reports, Vol 10, Iss 10, Pp 1639-1645 (2015)
The synaptonemal complex (SC) is a conserved protein complex that stabilizes interactions along homologous chromosomes (homologs) during meiosis. The SC regulates genetic exchanges between homologs, thereby enabling reductional division and the produ
Externí odkaz:
https://doaj.org/article/60a81136e3484a5dbf27b3fce373f500
Publikováno v:
eLife, Vol 6 (2017)
The synaptonemal complex (SC) is a polymer that spans ~100 nm between paired homologous chromosomes during meiosis. Its striated, periodic appearance in electron micrographs led to the idea that transverse filaments within this structure ‘crosslink
Externí odkaz:
https://doaj.org/article/3477523fe62a41e2a6e80ed4cb2b383a
Publikováno v:
Chromosoma
Alignment of the parental chromosomes during meiotic prophase is key to the formation of genetic exchanges, or crossovers, and consequently to the successful production of gametes. In almost all studied organisms, alignment involves synapsis: the ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b0cd99fc94f438f31c6fd93f1aa69a
https://doi.org/10.1007/s00412-021-00763-y
https://doi.org/10.1007/s00412-021-00763-y
Autor:
Lexy von Diezmann, Ofer Rog
Publikováno v:
The Journal of Physical Chemistry B. 125:6162-6170
Biomolecules are distributed within cells by molecular-scale diffusion and binding events that are invisible in standard fluorescence microscopy. These molecular search kinetics are key to understanding nuclear signaling and chromosome organization a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56b7a418da890165f3500de6229adb44
https://doi.org/10.1021/acs.jpcb.1c03040
https://doi.org/10.1021/acs.jpcb.1c03040
Autor:
Yinghua Su, Ho-Chen Lin, Li Szhen Teh, Fabienne Chevance, Ian James, Clara Mayfield, Kent G. Golic, James Gagnon, Ofer Rog, Colin Dale
Publikováno v:
Curr Biol
Many insects maintain mutualistic associations with bacterial endosymbionts, but little is known about how they originate in nature. In this study, we describe the establishment and manipulation of a synthetic insect-bacterial symbiosis in a weevil h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2dda49cbe1affb98b92991e096e537a
https://europepmc.org/articles/PMC10080585/
https://europepmc.org/articles/PMC10080585/
