Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Ofer, Binah"'
Autor:
Shunit Neeman-Egozi, Ido Livneh, Irit Dolgopyat, Udi Nussinovitch, Helena Milman, Nadav Cohen, Binyamin Eisen, Aaron Ciechanover, Ofer Binah
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4932 (2024)
The ubiquitin–proteasome system (UPS) is an essential mechanism responsible for the selective degradation of substrate proteins via their conjugation with ubiquitin. Since cardiomyocytes have very limited self-renewal capacity, as they are prone to
Externí odkaz:
https://doaj.org/article/3b1ff9ecfa7d43ff81bb3fabd8fc1e91
Autor:
Binyamin Eisen, Ofer Binah
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8657 (2023)
Duchenne muscular dystrophy (DMD) is an X-linked progressive muscle degenerative disease caused by mutations in the dystrophin gene, resulting in death by the end of the third decade of life at the latest. A key aspect of the DMD clinical phenotype i
Externí odkaz:
https://doaj.org/article/f66381719e624541bec0614025f07d8d
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/bcfd5da39476413d879573c8dd644014
Autor:
Eric N Jimenez-Vazquez, Michael Arad, Álvaro Macías, Maria L Vera-Pedrosa, Francisco Miguel Cruz, Lilian K Gutierrez, Ashley J Cuttitta, André Monteiro da Rocha, Todd J Herron, Daniela Ponce-Balbuena, Guadalupe Guerrero-Serna, Ofer Binah, Daniel E Michele, José Jalife
Publikováno v:
eLife, Vol 11 (2022)
Background: Patients with cardiomyopathy of Duchenne Muscular Dystrophy (DMD) are at risk of developing life-threatening arrhythmias, but the mechanisms are unknown. We aimed to determine the role of ion channels controlling cardiac excitability in t
Externí odkaz:
https://doaj.org/article/3180e35d001a43e7a82ff755b7a2af96
Autor:
Lubna Willi, Ifat Abramovich, Jonatan Fernandez-Garcia, Bella Agranovich, Margarita Shulman, Helena Milman, Polina Baskin, Binyamin Eisen, Daniel E. Michele, Michael Arad, Ofer Binah, Eyal Gottlieb
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9808 (2022)
Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin gene and dilated cardiomyopathy (DCM) is a major cause of morbidity and mortality in DMD patients. We tested the hypothesis that DCM is caused by metabolic impairments by empl
Externí odkaz:
https://doaj.org/article/65a7d50910c24349a3b270834be10f19
Autor:
Elisabeth Stelling, Melanie Ricke-Hoch, Sergej Erschow, Steve Hoffmann, Anke Katharina Bergmann, Maren Heimerl, Stefan Pietzsch, Karin Battmer, Alexandra Haase, Britta Stapel, Michaela Scherr, Jean-Luc Balligand, Ofer Binah, Denise Hilfiker-Kleiner
Publikováno v:
PLoS Biology, Vol 18, Iss 12, p e3000739 (2020)
Cardiac levels of the signal transducer and activator of transcription factor-3 (STAT3) decline with age, and male but not female mice with a cardiomyocyte-specific STAT3 deficiency conditional knockout (CKO) display premature age-related heart failu
Externí odkaz:
https://doaj.org/article/865e8d203dec44ada45be7c08db29fb5
Autor:
Binyamin Eisen, Ronen Ben Jehuda, Ashley J. Cuttitta, Lucy N. Mekies, Irina Reiter, Sindhu Ramchandren, Michael Arad, Daniel E. Michele, Ofer Binah
Publikováno v:
Stem Cell Research, Vol 29, Iss , Pp 111-114 (2018)
Duchenne muscular dystrophy (DMD) is an X-linked progressive muscle degenerative disease caused by mutations in the dystrophin gene. We generated induced pluripotent stem cells (iPSCs) from a 13-year-old male patient carrying a deletion mutation of e
Externí odkaz:
https://doaj.org/article/d79c103b1f9f407b90f27d64178fe354
Autor:
Yuval Shemer, Lucy N. Mekies, Ronen Ben Jehuda, Polina Baskin, Rita Shulman, Binyamin Eisen, Danielle Regev, Eloisa Arbustini, Brenda Gerull, Mihaela Gherghiceanu, Eyal Gottlieb, Michael Arad, Ofer Binah
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 7874 (2021)
LMNA-related dilated cardiomyopathy is an inherited heart disease caused by mutations in the LMNA gene encoding for lamin A/C. The disease is characterized by left ventricular enlargement and impaired systolic function associated with conduction defe
Externí odkaz:
https://doaj.org/article/163d673b362e41caa67adca85983e315
Autor:
Paz Ovics, Danielle Regev, Polina Baskin, Mor Davidor, Yuval Shemer, Shunit Neeman, Yael Ben-Haim, Ofer Binah
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7320 (2020)
Over the years, numerous groups have employed human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) as a superb human-compatible model for investigating the function and dysfunction of cardiomyocytes, drug screening and toxicity, dise
Externí odkaz:
https://doaj.org/article/82e21962f6b04edfae880070b834bf22
Autor:
Revital Schick, Lucy N Mekies, Yuval Shemer, Binyamin Eisen, Tova Hallas, Ronen Ben Jehuda, Meital Ben-Ari, Agnes Szantai, Lubna Willi, Rita Shulman, Michael Gramlich, Luna Simona Pane, Ilaria My, Dov Freimark, Marta Murgia, Gianluca Santamaria, Mihaela Gherghiceanu, Michael Arad, Alessandra Moretti, Ofer Binah
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205719 (2018)
AIMS:Dilated cardiomyopathy (DCM), a myocardial disorder that can result in progressive heart failure and arrhythmias, is defined by ventricular chamber enlargement and dilatation, and systolic dysfunction. Despite extensive research, the pathologica
Externí odkaz:
https://doaj.org/article/e1a99e6238e543028fefdc138f726611