Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ofek Oren"'
Autor:
Nitzan Shauloff, Ran Taube, Shani Ben-Zichri, Tal Peretz, Raz Jelinek, Ofek Oren, Ravit Malishev, Niv Papo
Publikováno v:
Cellular and Molecular Life Sciences. 78:2145-2155
BIM is a key apoptotic protein, participating in diverse cellular processes. Interestingly, recent studies have hypothesized that BIM is associated with the extensive neuronal cell death encountered in protein misfolding diseases, such as Alzheimer's
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dfe466b9452577ccee5ced6f0bec34e
https://doi.org/10.1007/s00018-020-03623-7
https://doi.org/10.1007/s00018-020-03623-7
Autor:
Ravit Malishev, Ofek Oren, Niv Papo, Raz Jelinek, Ran Taube, Daniel Nir Bloch, Shani Ben-Zichri
Publikováno v:
ACS chemical neuroscience. 12(24)
Aggregation of the β-Amyloid (Aβ) peptide in brain tissues is the hallmark of Alzheimer's disease (AD). While Aβ is presumed to be insidiously involved in the disease's pathophysiology, concrete mechanisms accounting for the role of Aβ in AD are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::348f8059a223b31714c2423142f0851e
https://pubmed.ncbi.nlm.nih.gov/34806861
https://pubmed.ncbi.nlm.nih.gov/34806861
Publikováno v:
Cellular and molecular life sciences : CMLS. 78(23)
A review of the multidisciplinary scientific literature reveals a large variety of amyloid-β (Aβ) oligomeric species, differing in molecular weight, conformation and morphology. These species, which may assemble via either on- or off-aggregation pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e22c37cec3491210eabfb7a3c29f53f
https://pubmed.ncbi.nlm.nih.gov/34643743
https://pubmed.ncbi.nlm.nih.gov/34643743
Autor:
Segev Naveh Tassa, Shiran Lacham-Hartman, Debra Toiber, Zeev Slobodnik, Niv Papo, Shani Ben Zichri, Ofek Oren, Raz Jelinek, Ekaterina Eremenko
Publikováno v:
ACS chemical neuroscience. 12(9)
It is currently believed that molecular agents that specifically bind to and neutralize the toxic proteins/peptides, amyloid β (Aβ42), tau, and the tau-derived peptide PHF6, hold the key to attenuating the progression of Alzheimer's disease (AD). W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c2f0d7c6a4b6b957340b4637ca7bec
https://pubmed.ncbi.nlm.nih.gov/33904703
https://pubmed.ncbi.nlm.nih.gov/33904703
Publikováno v:
ACS chemical neuroscience. 11(7)
Destabilization of plasma and inner mitochondrial membranes by extra- and intracellular amyloid β peptide (Aβ42) aggregates may lead to dysregulated calcium flux through the plasma membrane, mitochondrial-mediated apoptosis, and neuronal cell death
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ff26d5379d81826027fe60c400b6e6
https://pubmed.ncbi.nlm.nih.gov/32155047
https://pubmed.ncbi.nlm.nih.gov/32155047
Publikováno v:
ACS Chemical Neuroscience. 10:1488-1496
Intra- and extraneuronal deposition of amyloid β (Aβ) peptides have been linked to Alzheimer's disease (AD). While both intra- and extraneuronal Aβ deposits affect neuronal cell viability, the molecular mechanism by which these Aβ structures, esp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e1cf09fa213108f2634b7814b4d017
https://doi.org/10.1021/acschemneuro.8b00491
https://doi.org/10.1021/acschemneuro.8b00491
Publikováno v:
Biochemical Journal. 475:3087-3103
Aggregation and accumulation of the 42-residue amyloid β peptide (Aβ42) in the extracellular matrix and within neuronal cells is considered a major cause of neuronal cell cytotoxicity and death in Alzheimer's disease (AD) patients. Therefore, molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c19ec99772fa9dda2ff97076c150b1
https://doi.org/10.1042/bcj20180247
https://doi.org/10.1042/bcj20180247
Publikováno v:
Proteins. 87(9)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by selective death of motor neurons in the brainstem, motor cortex, and spinal cord, leading to muscle atrophy and eventually to death. It is currently held that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d3bdaffc8be1da9914a2173929e5d0
https://pubmed.ncbi.nlm.nih.gov/31017342
https://pubmed.ncbi.nlm.nih.gov/31017342
Publikováno v:
The Journal of biological chemistry. 292(38)
Molecular agents that specifically bind and neutralize misfolded and toxic superoxide dismutase 1 (SOD1) mutant proteins may find application in attenuating the disease progression of familial amyotrophic lateral sclerosis. However, high structural s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39777ae17156be077b0ed86fb13c829e
https://pubmed.ncbi.nlm.nih.gov/28768772
https://pubmed.ncbi.nlm.nih.gov/28768772