Novel Small Molecule Hsp90/Cdc37 Interface Inhibitors Indirectly Target K-Ras-Signaling.

Autor: Siddiqui FA; Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland., Parkkola H; Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland., Vukic V; Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.; Faculty of Technology, University of Novi Sad, 21000 Novi Sad, Serbia., Oetken-Lindholm C; Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland., Jaiswal A; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Kiriazis A; Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland., Pavic K; Cancer Cell Biology and Drug Discovery Group, Department of Life Sciences and Medicine, University of Luxembourg, 4362 Esch-sur-Alzette, Luxembourg., Aittokallio T; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, N-0310 Oslo, Norway.; Centre for Biostatistics and Epidemiology (OCBE), Faculty of Medicine, University of Oslo, N-0372 Oslo, Norway., Salminen TA; Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, 20520 Turku, Finland., Abankwa D; Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.; Cancer Cell Biology and Drug Discovery Group, Department of Life Sciences and Medicine, University of Luxembourg, 4362 Esch-sur-Alzette, Luxembourg.

Publikováno v: Cancers [Cancers (Basel)] 2021 Feb 23; Vol. 13 (4). Date of Electronic Publication: 2021 Feb 23.

PO-092 Inhibition of the mTORC1-pathway can feedback-activate H-RAS or K-RAS

Autor: Posada, I.M., Lectez, B., Siddiqui, F., Oetken-Lindholm, C., Sharma, M., Yetukuri, L., Zhou, Y., Aittokallio, T., Abankwa, D.

Publikováno v: In ESMO Open 30 June-3 July 2018 3 Supplement 2:A57-A57

Heat shock proteins as hallmarks of cancer: insights from molecular mechanisms to therapeutic strategies.

Autor: Zuo, Wei-Fang¹ (AUTHOR), Pang, Qiwen¹ (AUTHOR), Zhu, Xinyu¹ (AUTHOR), Yang, Qian-Qian¹ (AUTHOR), Zhao, Qian² (AUTHOR), He, Gu³ (AUTHOR) hegu@scu.edu.cn, Han, Bo¹ (AUTHOR), Huang, Wei¹ (AUTHOR) huangwei@cdutcm.edu.cn

Publikováno v: Journal of Hematology & Oncology. 9/4/2024, Vol. 17 Issue 1, p1-58. 58p.

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Rapalogs can promote cancer cell stemness in vitro in a Galectin-1 and H-ras-dependent manner.

Autor: Posada IMD; Turku Center for Biotechnology, Åbo Akademi University, Tykistökatu 6B, Turku, Finland., Lectez B; Turku Center for Biotechnology, Åbo Akademi University, Tykistökatu 6B, Turku, Finland., Sharma M; Turku Center for Biotechnology, Åbo Akademi University, Tykistökatu 6B, Turku, Finland., Oetken-Lindholm C; Turku Center for Biotechnology, Åbo Akademi University, Tykistökatu 6B, Turku, Finland., Yetukuri L; Turku Center for Biotechnology, Åbo Akademi University, Tykistökatu 6B, Turku, Finland.; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland., Zhou Y; Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, United States of America., Aittokallio T; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Department of Mathematics and Statistics, University of Turku, Turku, Finland., Abankwa D; Turku Center for Biotechnology, Åbo Akademi University, Tykistökatu 6B, Turku, Finland.

Publikováno v: Oncotarget [Oncotarget] 2017 Jul 04; Vol. 8 (27), pp. 44550-44566.