Inflammatory Mesenchymal Stromal Cells and IFN-responsive T cells are key mediators of human bone marrow niche remodeling in CHIP and MDS.

Autor: Prummel KD, Woods K, Kholmatov M, Schmitt EC, Vlachou EP, Poschmann G, Stühler K, Wehner R, Schmitz M, Winter S, Oelschlaegel U, Schwartz LS, Moura PL, Hellström-Lindberg E, Theobald M, Trowbridge JJ, Platzbecker U, Zaugg JB, Guezguez B

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Nov 27. Date of Electronic Publication: 2024 Nov 27.

Immune-monitoring of myelodysplastic neoplasms: Recommendations from the i4MDS consortium.

Autor: Tentori CA; Humanitas Clinical and Research Center-IRCCS & Department of Biomedical Sciences Humanitas University Milan Italy.; Comprehensive Cancer Centre, King's College London UK., Zhao LP; Hématologie seniors Hôpital Saint-Louis, Assistance Publique des Hôpitaux de Paris (APHP) Paris France.; INSERM UMR_S1160, Institut de Recherche Saint Louis Université Paris Cité Paris France., Tinterri B; Humanitas Clinical and Research Center-IRCCS & Department of Biomedical Sciences Humanitas University Milan Italy., Strange KE; Comprehensive Cancer Centre, King's College London UK.; Research Group of Molecular Immunology Francis Crick Institute London UK., Zoldan K; Department of Medicine 1, Haematology, Cellular Therapy, Hemostaseology and Infectious Diseases University Medical Center Leipzig Leipzig Germany., Dimopoulos K; Department of Clinical Biochemistry Bispebjerg and Frederiksberg Hospital Copenhagen Denmark.; Department of Pathology, Rigshospitalet Copenhagen University Hospital Copenhagen Denmark., Feng X; Hematology Branch, National Heart, Lung and Blood Institute Bethesda Maryland USA., Riva E; Humanitas Clinical and Research Center-IRCCS & Department of Biomedical Sciences Humanitas University Milan Italy., Lim B; Imperial College London London UK., Simoni Y; Université Paris Cité, CNRS, INSERM, Institut Cochin Paris France., Murthy V; Centre for Clinical Haematology, University Hospitals of Birmingham Birmingham UK., Hayes MJ; Cell & Developmental Biology Vanderbilt University School of Medicine Nashville Tennessee USA.; Pathology, Microbiology and Immunology, Vanderbilt University Medical Center Nashville Tennessee USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center Nashville Tennessee USA., Poloni A; Department of Clinical and Molecular Sciences Università Politecnica delle Marche Ancona Italy., Padron E; Moffitt Cancer Center, Malignant Hematology Department Tampa USA., Cardoso BA; Universidade Católica Portuguesa Faculdade de Medicina Portugal.; Universidade Católica Portuguesa, Centro de Investigação Interdisciplinar em Saúde Portugal., Cross M; Department of Medicine 1, Haematology, Cellular Therapy, Hemostaseology and Infectious Diseases University Medical Center Leipzig Leipzig Germany., Winter S; Medical Clinic I, University Hospital Carl Gustav Carus, TU Dresden Dresden Germany., Santaolalla A; Comprehensive Cancer Centre, King's College London UK., Patel BA; Hematology Branch, National Heart, Lung and Blood Institute Bethesda Maryland USA., Groarke EM; Hematology Branch, National Heart, Lung and Blood Institute Bethesda Maryland USA., Wiseman DH; Division of Cancer Sciences The University of Manchester Manchester UK.; The Christie NHS Foundation Trust Manchester UK., Jones K; Immunophenotyping Laboratory (Synnovis Analytics LLP) Southeast Haematological Malignancy Diagnostic Service, King's College Hospital London UK., Jamieson L; Immunophenotyping Laboratory (Synnovis Analytics LLP) Southeast Haematological Malignancy Diagnostic Service, King's College Hospital London UK., Manogaran C; Immunophenotyping Laboratory (Synnovis Analytics LLP) Southeast Haematological Malignancy Diagnostic Service, King's College Hospital London UK., Daver N; University of Texas MD Anderson Cancer Center Houston, Texas USA., Gallur L; Hematology Department, Vall d'hebron University Hospital, Vall d'hebron Institut of Oncology (VHIO) Vall d'Hebron Barcelona Hospital Campus Barcelona Spain., Ingram W; Department of Haematology University Hospital of Wales Cardiff UK., Ferrell PB; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center Nashville Tennessee USA.; Vanderbilt University Medical Center Nashville Tennessee USA., Sockel K; Medical Clinic I, University Hospital Carl Gustav Carus, TU Dresden Dresden Germany., Dulphy N; INSERM UMR_S1160, Institut de Recherche Saint Louis Université Paris Cité Paris France.; Laboratoire d'Immunologie et d'Histocompatibilité, Assistance Publique des Hôpitaux de Paris (APHP), Hôpital Saint-Louis Paris France.; Institut Carnot OPALE, Institut de Recherche Saint-Louis, Hôpital Saint-Louis Paris France., Chapuis N; Université Paris Cité, CNRS, INSERM, Institut Cochin Paris France.; Assistance Publique-Hôpitaux de Paris Centre, Hôpital Cochin Paris France., Kubasch AS; Department of Medicine 1, Haematology, Cellular Therapy, Hemostaseology and Infectious Diseases University Medical Center Leipzig Leipzig Germany., Olsnes AM; Section for Hematology, Department of Medicine Haukeland University Hospital Bergen Norway.; Department of Clinical Science Faculty of Medicine, University of Bergen Bergen Norway., Kulasekararaj A; Department of Haematology King's College Hospital, Denmark Hill London UK., De Lavellade H; Haematology Department Guy's and St Thomas NHS Trust London UK., Kern W; MLL Münchner Leukämielabor Munich Germany., Van Hemelrijck M; Comprehensive Cancer Centre, King's College London UK., Bonnet D; Hematopoietic Stem Cell Laboratory Francis Crick Institute London UK., Westers TM; Department of Hematology, Cancer Center Amsterdam Amsterdam University Medical Centers, location VU University Medical Center Amsterdam The Netherlands., Freeman S; Institute of Immunology and Immunotherapy University of Birmingham Birmingham UK., Oelschlaegel U; Medical Clinic I, University Hospital Carl Gustav Carus, TU Dresden Dresden Germany., Valcarcel D; Hematology Department, Vall d'hebron University Hospital, Vall d'hebron Institut of Oncology (VHIO) Vall d'Hebron Barcelona Hospital Campus Barcelona Spain., Raddi MG; Myelodysplastic Syndrome Unit, Hematology Division Azienda Ospedaliero-Universitaria Careggi, University of Florence Florence Italy., Grønbæk K; Department of Hematology, Rigshospitalet Copenhagen University Hospital Copenhagen Denmark.; Biotech Research and Innovation Center (BRIC) University of Copenhagen Copenhagen Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark., Fontenay M; Université Paris Cité, CNRS, INSERM, Institut Cochin Paris France.; Assistance Publique-Hôpitaux de Paris Centre, Hôpital Cochin Paris France., Loghavi S; University of Texas MD Anderson Cancer Center Houston, Texas USA., Santini V; Myelodysplastic Syndrome Unit, Hematology Division Azienda Ospedaliero-Universitaria Careggi, University of Florence Florence Italy., Almeida AM; Hematology Department Hospital da Luz Lisboa Lisboa Portugal.; Deanery Faculdade de Medicina, UCP Lisboa Portugal., Irish JM; Cell & Developmental Biology Vanderbilt University School of Medicine Nashville Tennessee USA.; Pathology, Microbiology and Immunology, Vanderbilt University Medical Center Nashville Tennessee USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center Nashville Tennessee USA., Sallman DA; Moffitt Cancer Center, Malignant Hematology Department Tampa USA., Young NS; Hematology Branch, National Heart, Lung and Blood Institute Bethesda Maryland USA., van de Loosdrecht AA; Department of Hematology, Cancer Center Amsterdam Amsterdam University Medical Centers, location VU University Medical Center Amsterdam The Netherlands., Adès L; Hématologie seniors Hôpital Saint-Louis, Assistance Publique des Hôpitaux de Paris (APHP) Paris France.; Université Paris Cité, CNRS, INSERM, Institut Cochin Paris France., Della Porta MG; Humanitas Clinical and Research Center-IRCCS & Department of Biomedical Sciences Humanitas University Milan Italy., Cargo C; Leeds Teaching Hospital Leeds UK., Platzbecker U; Department of Medicine 1, Haematology, Cellular Therapy, Hemostaseology and Infectious Diseases University Medical Center Leipzig Leipzig Germany., Kordasti S; Comprehensive Cancer Centre, King's College London UK.; Department of Clinical and Molecular Sciences Università Politecnica delle Marche Ancona Italy.; Haematology Department Guy's and St Thomas NHS Trust London UK.

Publikováno v: HemaSphere [Hemasphere] 2024 May 15; Vol. 8 (5), pp. e64. Date of Electronic Publication: 2024 May 15 (Print Publication: 2024).

Multicenter prospective evaluation of diagnostic potential of flow cytometric aberrancies in myelodysplastic syndromes by the ELN iMDS flow working group.

Autor: Kern W; MLL Munich Leukemia Laboratory, Munich, Germany., Westers TM; Department of Hematology, Amsterdam University Medical Centers, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands., Bellos F; MLL Munich Leukemia Laboratory, Munich, Germany., Bene MC; Hematology Biology, Nantes University Hospital, Nantes, France., Bettelheim P; Department of Hematology, Elisabethinen Hospital, Linz, Upper Austria, Austria., Brodersen LE; Hematologics, Inc., Seattle, Washington, USA., Burbury K; Peter MacCallum Cancer Centre, Melbourne, Australia., Chu SC; Department of Hematology and Oncology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan., Cullen M; Haematological Malignancy Diagnostic Service, St James's University Hospital, Leeds, UK., Porta MD; Department of Biomedical Sciences, IRCCS Humanitas Research Hospital, Humanitas University, Milan, Italy., Dunlop AS; Department of Haematology, College Hospital London, London, England., Johansson U; Laboratory Medicine, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK., Matarraz S; Cytometry Service (NUCLEUS), Department of Medicine and IBSAL, Cancer Research Center (IBMCC, University of Salamanca-CSIC), Salamanca, Spain and Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Salamanca, Spain., Oelschlaegel U; Department of Internal Medicine, University Hospital of Technical University Dresden, Dresden, Germany., Ogata K; Metropolitan Research and Treatment Centre for Blood Disorders (MRTC Japan), Tokyo, Japan., Porwit A; Division of Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden., Preijers F; Department of Laboratory Medicine, Laboratory of Hematology, Radboudumc, Nijmegen, The Netherlands., Psarra K; Immunology Histocompatibility Department, Evangelismos Hospital, Athens, Greece., Saft L; Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital and Institute, Stockholm, Sweden., Subirá D; Department of Medical Immunology, Hospital Universitario de Guadalajara, Guadalajara, Spain., Weiß E; MLL Munich Leukemia Laboratory, Munich, Germany., van der Velden VHJ; Laboratory Medical Immunology, Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., van de Loosdrecht A; Department of Hematology, Amsterdam University Medical Centers, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands.

Publikováno v: Cytometry. Part B, Clinical cytometry [Cytometry B Clin Cytom] 2023 Jan; Vol. 104 (1), pp. 51-65. Date of Electronic Publication: 2022 Nov 23.

MDS-PB13 Score - Blood based detection of aberrancies by flow cytometry in patients with suspected and confirmed Myelodysplastic Neoplasms.

Autor: Oelschlaegel U; Department of Internal Medicine I, University Hospital Carl Gustav Carus, Faculty of Medicine Carl Gustav Carus, Technical University Dresden, Dresden, Germany. uta.oelschlaegel@ukdd.de., Winter S; Department of Internal Medicine I, University Hospital Carl Gustav Carus, Faculty of Medicine Carl Gustav Carus, Technical University Dresden, Dresden, Germany., Sockel K; Department of Internal Medicine I, University Hospital Carl Gustav Carus, Faculty of Medicine Carl Gustav Carus, Technical University Dresden, Dresden, Germany., Epp K; Department of Internal Medicine I, University Hospital Carl Gustav Carus, Faculty of Medicine Carl Gustav Carus, Technical University Dresden, Dresden, Germany., Schadt J; Department of Internal Medicine I, University Hospital Carl Gustav Carus, Faculty of Medicine Carl Gustav Carus, Technical University Dresden, Dresden, Germany., Röhnert MA; Department of Internal Medicine I, University Hospital Carl Gustav Carus, Faculty of Medicine Carl Gustav Carus, Technical University Dresden, Dresden, Germany., Krüger T; Department of Internal Medicine I, University Hospital Carl Gustav Carus, Faculty of Medicine Carl Gustav Carus, Technical University Dresden, Dresden, Germany., Ruhnke L; Department of Internal Medicine I, University Hospital Carl Gustav Carus, Faculty of Medicine Carl Gustav Carus, Technical University Dresden, Dresden, Germany., Bornhäuser M; Department of Internal Medicine I, University Hospital Carl Gustav Carus, Faculty of Medicine Carl Gustav Carus, Technical University Dresden, Dresden, Germany.; National Center for Tumor Diseases (NCT), Dresden, Germany., Platzbecker U; Clinic and Policlinic for Hematology, Cellular Therapy Hemostaseology and Infectiology, University Hospital Leipzig, Leipzig, Germany., Kroschinsky F; Department of Internal Medicine I, University Hospital Carl Gustav Carus, Faculty of Medicine Carl Gustav Carus, Technical University Dresden, Dresden, Germany., von Bonin M; Department of Internal Medicine I, University Hospital Carl Gustav Carus, Faculty of Medicine Carl Gustav Carus, Technical University Dresden, Dresden, Germany.

Publikováno v: Leukemia [Leukemia] 2024 Feb; Vol. 38 (2), pp. 446-450. Date of Electronic Publication: 2024 Jan 16.

Monitoring treatment with 5-Azacitidine by flow cytometry predicts duration of hematological response in patients with myelodysplastic syndrome.

Autor: Subirá D; Flow Cytometry Unit, Department of Hematology, Hospital Universitario de Guadalajara, c/Donante de Sangre s.n., 19002, Guadalajara, Spain. dosuperez@yahoo.es., Alhan C; Amsterdam University Medical Centers, VU University Medical Center, Amsterdam, Netherlands., Oelschlaegel U; Medical Clinic and Policlinic I, University Hospital of TU Dresden, Dresden, Germany., Porwit A; Department of Clinical Sciences, Division Oncology and Pathology, Lund University, Lund, Sweden., Psarra K; Department of Immunology and Histocompatibility, Evangelismos Hospital, Athens, Greece., Westers TM; Amsterdam University Medical Centers, VU University Medical Center, Amsterdam, Netherlands., Golbano N; Department of Hematology, Hospital Universitario de Guadalajara, Guadalajara, Spain., Nilsson L; Department of Haematology and Coagulation Disorders, Skåne University Hospital, Lund, Sweden., van de Loosdrecht AA; Amsterdam University Medical Centers, VU University Medical Center, Amsterdam, Netherlands., de Miguel D; Department of Hematology, Hospital Universitario de Guadalajara, Guadalajara, Spain.

Publikováno v: Annals of hematology [Ann Hematol] 2021 Jul; Vol. 100 (7), pp. 1711-1722. Date of Electronic Publication: 2021 Jan 09.