Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Odilia Popanda"'
Autor:
Sonja Neumeyer, Odilia Popanda, Dominic Edelmann, Katja Butterbach, Csaba Toth, Wilfried Roth, Hendrik Bläker, Ruijingfang Jiang, Esther Herpel, Cornelia Jäkel, Peter Schmezer, Lina Jansen, Elizabeth Alwers, Axel Benner, Barbara Burwinkel, Michael Hoffmeister, Hermann Brenner, Jenny Chang-Claude
Publikováno v:
Epigenetics, Vol 14, Iss 5, Pp 477-493 (2019)
Involvement of sex hormones in colorectal cancer (CRC) development has been linked to oestrogen receptor β (ERβ). Expression of ERβ is found reduced in tumour tissue and inversely related to mortality. However, mechanisms are not well understood.
Externí odkaz:
https://doaj.org/article/c31ee8df21a748cfb7bee0d8c682945e
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Radiotherapy is an efficient tool in cancer treatment, but it brings along the risk of side effects such as fibrosis in the irradiated healthy tissue thus limiting tumor control and impairing quality of life of cancer survivors. Knowledge on radiatio
Externí odkaz:
https://doaj.org/article/90a020c7cf5f4043b8346e6d05e66105
Autor:
Cornelia Jäkel, Frank Bergmann, Reka Toth, Yassen Assenov, Daniel van der Duin, Oliver Strobel, Thomas Hank, Günter Klöppel, Craig Dorrell, Markus Grompe, Joshua Moss, Yuval Dor, Peter Schirmacher, Christoph Plass, Odilia Popanda, Peter Schmezer
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tumor with largely unknown biology. Here, the authors perform genome- and epigenome-wide analyses from normal and ACC pancreatic tissue that identify aberrations in genome stability and
Externí odkaz:
https://doaj.org/article/d69c18b22f7a4f1a816b05e01db8f13e
Autor:
Chun-Shan Liu, Reka Toth, Ali Bakr, Ashish Goyal, Md Saiful Islam, Kersten Breuer, Anand Mayakonda, Yu-Yu Lin, Peter Stepper, Tomasz P. Jurkowski, Marlon R. Veldwijk, Elena Sperk, Carsten Herskind, Pavlo Lutsik, Dieter Weichenhan, Christoph Plass, Peter Schmezer, Odilia Popanda
Publikováno v:
Cancers, Vol 13, Iss 10, p 2455 (2021)
Radiotherapy, a common component in cancer treatment, can induce adverse effects including fibrosis in co-irradiated tissues. We previously showed that differential DNA methylation at an enhancer of diacylglycerol kinase alpha (DGKA) in normal dermal
Externí odkaz:
https://doaj.org/article/f595f7d26f884f69922f67c23ff4ad5a
Autor:
Christoph Weigel, Marlon R. Veldwijk, Christopher C. Oakes, Petra Seibold, Alla Slynko, David B. Liesenfeld, Mariona Rabionet, Sabrina A. Hanke, Frederik Wenz, Elena Sperk, Axel Benner, Christoph Rösli, Roger Sandhoff, Yassen Assenov, Christoph Plass, Carsten Herskind, Jenny Chang-Claude, Peter Schmezer, Odilia Popanda
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Radiotherapy can induce fibrosis in cancer patients, limiting its use in clinical settings. Here, the authors identify a differentially methylated enhancer of the lipid kinase DGKA in fibroblasts from breast cancer patients developing fibrosis after
Externí odkaz:
https://doaj.org/article/8d2cbcdc585d437387a5d8eedf91802c
Autor:
Burkhard Greve, Tobias Bölling, Susanne Amler, Ute Rössler, Maria Gomolka, Claudia Mayer, Odilia Popanda, Kristin Dreffke, Astrid Rickinger, Eberhard Fritz, Friederike Eckardt-Schupp, Christina Sauerland, Herbert Braselmann, Wiebke Sauter, Thomas Illig, Dorothea Riesenbeck, Stefan Könemann, Normann Willich, Simone Mörtl, Hans Theodor Eich, Peter Schmezer
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47185 (2012)
Radiotherapy is a powerful cure for several types of solid tumours, but its application is often limited because of severe side effects in individual patients. With the aim to find biomarkers capable of predicting normal tissue side reactions we anal
Externí odkaz:
https://doaj.org/article/02319a24f0e3479fac22b5f76f949cf0
Autor:
Cornelia M. Ulrich, Johanna W. Lampe, John D. Potter, Karel D. Klika, Odilia Popanda, Christoph Weigel, Reka Toth, Nina Habermann, Akke Botma, David B. Liesenfeld
Supplementary Materials and Methods. Supplementary Figure 1: Study design of the ABC intervention study. Supplementary Figure 2: Intracellular concentrations of free salicylate in aspirin treated colorectal cancer cell lines expressed as nmol per tot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00eb4f1cf3044dfe3e96a96a8e400dfc
https://doi.org/10.1158/1055-9965.22437900
https://doi.org/10.1158/1055-9965.22437900
Autor:
Cornelia M. Ulrich, Johanna W. Lampe, John D. Potter, Karel D. Klika, Odilia Popanda, Christoph Weigel, Reka Toth, Nina Habermann, Akke Botma, David B. Liesenfeld
Background: Aspirin use is an effective strategy for the chemoprevention of colorectal cancer, even at low doses. However, in order to implement aspirin interventions, risk–benefit balances and biologic mechanisms need to be better defined; to furt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f82dd5d92fa09860002766d09f8490f
https://doi.org/10.1158/1055-9965.c.6516111.v1
https://doi.org/10.1158/1055-9965.c.6516111.v1
Autor:
Chun‐Shan Liu, Inmaculada Rioja, Ali Bakr, Marlon R. Veldwijk, Elena Sperk, Carsten Herskind, Dieter Weichenhan, Rab K. Prinjha, Christoph Plass, Peter Schmezer, Odilia Popanda
Publikováno v:
International Journal of Cancer. 151:275-286
Radiotherapy can induce various adverse effects including fibrosis in cancer patients. Radiation-induced aberrant expression of profibrotic genes has been associated with dysregulated epigenetic mechanisms. Pan-BET (bromodomain and extraterminal doma
Autor:
Patrick Müller, Jeroen Krijgsveld, Ahmed Sadik, Christiane A. Opitz, Gianluca Sigismondo, Odilia Popanda, Pavlo Lutsik, Kersten Breuer, Dieter Weichenhan, Alice Cross, Chun-Shan Liu, Christoph Plass, Ramya Lakshmana Iyer, Joschka Hey, Ali Bakr, Peter Schmezer, Ashish Goyal, Max Trauernicht
Publikováno v:
Nucleic Acids Research
The inhibitor of DNA-binding 3 (ID3) is a transcriptional regulator that limits interaction of basic helix-loop-helix transcription factors with their target DNA sequences. We previously reported that ID3 loss is associated with mutational signatures