Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Odile Ludwig"'
1
Synthesis of a new series of purine derivatives and their anti-cyclin-dependent kinase activities
Autor: Laurent Meijer, Michel Legraverend, Odile Ludwig, Sophie Leclerc
Publikováno v: Journal of Heterocyclic Chemistry. 38:299-303
The synthesis of new purine derivatives designed to inhibit cell cycle regulating cyclin-dependent kinases (CDKs), is reported. These compounds, related to olomoucine and roscovitine, are characterised by the presence of apyrrolidine methanol substit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::029645ba47ab636aadcd6cdcdc4fcd25
https://doi.org/10.1002/jhet.5570380145
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2
Cyclin-Dependent Kinase Inhibition by New C-2 Alkynylated Purine Derivatives and Molecular Structure of a CDK2−Inhibitor Complex
Autor: Odile Ludwig, Michel Legraverend, Paul Tunnah, David S. Grierson, Jane A. Endicott, Maryse Leost, Laurent Meijer, Martin E.M. Noble, Pierre Ducrot
Publikováno v: Journal of Medicinal Chemistry. 43:1282-1292
A new series of 2,6,9-trisubstituted purines, characterized by the presence of a common alkynyl substituent at C-2 and a range of different anilino/benzylamino groups at C-6, were synthesized. These compounds were evaluated for their capacity to inhi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770b9502d02fa1b6e7e7bf42cc97f0a7
https://doi.org/10.1021/jm9911130
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3
Synthesis of new non-nucleoside inhibitors of HIV-1
Autor: Emile Bisagni, Odile Ludwig, Anne-Marie Aubertin, Valerie Dolle, Michel Legraverend, Chi Hung Nguyen
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:173-178
Some new 4-arylthio-pyridinones which are related to non-nucleoside RT inhibitors of HIV-1 exhibited significant antiviral activities in cell culture. They have been synthesized from different β-keto esters.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57d2a7293a4d1b17abc116ef54e2297c
https://doi.org/10.1016/0960-894x(95)00584-g
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4
Synthesis of new carbocyclic oxetanocin analogues
Autor: L. Chertanova, Odile Ludwig, Anne-Marie Aubertin, Michel Legraverend, T. Gharbaoui, Emile Bisagni
Publikováno v: Tetrahedron. 51:1641-1652
Carbocyclic oxetanocin analogues containing 3-fluoro or 3-hydroxy cyclobutyl moieties and different natural bases, have been prepared from the olefinic precursors either by direct fluoro-iodination (AgF-I2) or by DAST fluorination of the bromhydrin.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e309ad9524219b89549b2ccdf3ea1746
https://doi.org/10.1016/0040-4020(94)01031-t
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6
ChemInform Abstract: Synthesis of C2 Alkynylated Purines, a New Family of Potent Inhibitors of Cyclin-Dependent Kinases
Autor: Laurent Meijer, Odile Ludwig, Michel Legraverend, Emile Bisagni, Sébastien Leclerc
Publikováno v: ChemInform. 29
The synthesis of a new family of inhibitors of the cell cycle regulating cyclin-dependent kinases (CDK's) is reported. These compounds, related to the purines olomoucine and roscovitine, are characterised by the presence of alkynylated side chains at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::937849d6dc01d50733385099adc36270
https://doi.org/10.1002/chin.199830175
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7
Targeting the cell cycle and the PI3K pathway: a possible universal strategy to reactivate innate tumor suppressor programmes in cancer cells
Autor: Odile Ludwig, Michel Legraverend, Thérèse David-Pfeuty, David S. Grierson
Publikováno v: International Journal of Oncology
International Journal of Oncology, Spandidos Publications, 2010, 36, pp.873-881
Corruption of the Rb and p53 pathways occurs in virtually all human cancers. This could be because it lends oncogene-bearing cells a surfeit of Cdk activity and growth, enabling them to elaborate strategies to evade tumor-suppressive mechanisms and d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1165584b4b878f7ac61dd492f61cf1e8
https://pubmed.ncbi.nlm.nih.gov/20198331
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8
In Vitro Evaluation of a Novel 2,6,9-Trisubstituted Purine Acting As a Cyclin-Dependent Kinase Inhibitor
Autor: Laurent Meijer, Odile Ludwig, Emile Bisagni, Vincent Favaudon, Ramin Sadri, Sophie Leclerc, Nicole Giocanti, Michel Legraverend
Publikováno v: Annals of the New York Academy of Sciences. 886:180-182
NICOLE GIOCANTI,a RAMIN SADRI,a MICHEL LEGRAVEREND,b ODILE LUDWIG,b EMILE BISAGNI,bSOPHIE LECLERC,c LAURENT MEIJER,c AND VINCENT FAVAUDONa.d aU 350 INSERM and bUMR 176 CNRS, Institut Curie, Centre Universitaire, 91405 Orsay, France cUPR 9042 CNRS, St
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f91163e2635152868ceb4726762ba9d
https://doi.org/10.1111/j.1749-6632.1999.tb09411.x
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9
Synthesis of C2 alkynylated purines, a new family of potent inhibitors of cyclin-dependent kinases
Autor: Laurent Meijer, Michel Legraverend, Odile Ludwig, Sébastien Leclerc, Emile Bisagni
Publikováno v: Bioorganicmedicinal chemistry letters. 8(7)
The synthesis of a new family of inhibitors of the cell cycle regulating cyclin-dependent kinases (CDK's) is reported. These compounds, related to the purines olomoucine and roscovitine, are characterised by the presence of alkynylated side chains at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0edb178dc3194d39b3885859bb306c55
https://pubmed.ncbi.nlm.nih.gov/9871543
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