Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentation.

Autor: Cécile Esnault, Guillaume Cornelis, Odile Heidmann, Thierry Heidmann

Publikováno v: PLoS Genetics, Vol 9, Iss 3, p e1003400 (2013)

Syncytins are envelope genes of retroviral origin that have been co-opted for a role in placentation. They promote cell-cell fusion and are involved in the formation of a syncytium layer--the syncytiotrophoblast--at the materno-fetal interface. They

Externí odkaz: https://doaj.org/article/f70228f2e1584f2696cf04b18555c779

Capture of a Hyena-Specific Retroviral Envelope Gene with Placental Expression Associated in Evolution with the Unique Emergence among Carnivorans of Hemochorial Placentation in Hyaenidae

Autor: Odile Heidmann, Mathis Funk, Alan J Conley, Guillaume Cornelis, Thierry Heidmann, Stephen E. Glickman, Cécile Vernochet, Anne Dupressoir

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2019, 93 (4), ⟨10.1128/JVI.01811-18⟩
Journal of virology, vol 93, iss 4

Capture of retroviral envelope genes from endogenous retroviruses has played a role in the evolution of mammals, with evidence for the involvement of these genes in the formation of the maternofetal interface of the placenta. It has been shown that t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e421e8774fe155fd3b02638c6d9af90
https://hal.archives-ouvertes.fr/hal-02390834

An endogenous retroviral envelope syncytin and its cognate receptor identified in the viviparous placental Mabuya lizard

Autor: Mathis Funk, Guillaume Meurice, Thierry Heidmann, Odile Heidmann, Guillaume Cornelis, Martha Patricia Ramírez-Pinilla, Aurélien Miralles, Francisca Leal, Oscar A. Tarazona, Anne Dupressoir, Cécile Vernochet

Publikováno v: Proceedings of the National Academy of Sciences. 114

Syncytins are envelope genes from endogenous retroviruses that have been captured during evolution for a function in placentation. They have been found in all placental mammals in which they have been searched, including marsupials. Placental structu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::720ace4fba52fb7e71e204c94dd2c359
https://doi.org/10.1073/pnas.1714590114

Genome-Wide Screening of Retroviral Envelope Genes in the Nine-Banded Armadillo (Dasypus novemcinctus, Xenarthra) Reveals an Unfixed Chimeric Endogenous Betaretrovirus Using the ASCT2 Receptor

Autor: Baptiste Mulot, Odile Heidmann, Anne Dupressoir, Cécile Vernochet, Sébastien Malicorne, Frédéric Delsuc, Thierry Heidmann, Guillaume Cornelis

Publikováno v: Journal of Virology
Journal of Virology, 2016, 90 (18), pp.8132-8149. ⟨10.1128/JVI.00483-16⟩
Journal of Virology, American Society for Microbiology, 2016, 90 (18), pp.8132-8149. ⟨10.1128/JVI.00483-16⟩

Retroviruses enter host cells through the interaction of their envelope (Env) protein with a cell surface receptor, which triggers the fusion of viral and cellular membranes. The sodium-dependent neutral amino acid transporter ASCT2 is the common rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbad495d199ce69082fcc9f8e119c944
https://hal.science/hal-01879328

Placental syncytins: Genetic disjunction between the fusogenic and immunosuppressive activity of retroviral envelope proteins

Autor: Bertrand Ducos, Odile Heidmann, Marianne Mangeney, Isabelle Bouallaga, Géraldine Schlecht-Louf, Martial Renard, Thierry Heidmann, Aurélien Richaud, Claire Letzelter

Publikováno v: Proceedings of the National Academy of Sciences. 104:20534-20539

We have previously demonstrated that the envelope proteins of a murine and primate retrovirus are immunosuppressive in vivo . This property was manifested by the ability of the proteins, when expressed by allogeneic tumor cells normally rejected by e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50b7041e9bdd0a4df5754c3e0802d76
https://doi.org/10.1073/pnas.0707873105