Identification of a novel human LAP1 isoform that is regulated by protein phosphorylation.

Autor: Mariana Santos, Sara C Domingues, Patrícia Costa, Thorsten Muller, Sara Galozzi, Katrin Marcus, Edgar F da Cruz e Silva, Odete A da Cruz e Silva, Sandra Rebelo

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e113732 (2014)

Lamina associated polypeptide 1 (LAP1) is an integral protein of the inner nuclear membrane that is ubiquitously expressed. LAP1 binds to lamins and chromatin, probably contributing to the maintenance of the nuclear envelope architecture. Moreover, L

Externí odkaz: https://doaj.org/article/781c73b50efb4966b8c9a41bb433f283

The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate.

Autor: Mariana Santos, Sandra Rebelo, Paula J M Van Kleeff, Connie E Kim, William T Dauer, Margarida Fardilha, Odete A da Cruz E Silva, Edgar F da Cruz E Silva

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e76788 (2013)

Protein phosphatase 1 (PP1) binding proteins are quintessential regulators, determining substrate specificity and defining subcellular localization and activity of the latter. Here, we describe a novel PP1 binding protein, the nuclear membrane protei

Externí odkaz: https://doaj.org/article/aa03d26da1d141e18470d8003e4c191a

Mitochondria dysfunction and impaired response to oxidative stress promotes proteostasis disruption in aged human cells

Autor: Diogo Trigo, André Nadais, Ana Carvalho, Bárbara Morgado, Francisco Santos, Sandrina Nóbrega-Pereira, Odete A.B. da Cruz e Silva

Publikováno v: Mitochondrion.

The plastic architecture of the mitochondrial network and its dynamic structure play crucial roles ensuring that varying energetic demands are rapidly met. Given the brain's high energy demand, mitochondria play a particularly critical role in neuron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e98b9d7623e3790db0b5db3e1ae46aeb
https://pubmed.ncbi.nlm.nih.gov/36273801

CSF biomarker variability in the Alzheimer's Association quality control program

Autor: Sabine Haustein, Eva Arkblad, Manfred Windisch, Walter Maetzler, Annette Spreer, Flora Berisha, Knudsen Cindy Søndersø, Hiroyuki Arai, Ralph Martin, Muriel Quillard, Marcel M. Verbeek, Lucilla Parnetti, Robert M. Umek, Aurélie Bedel, Silvana Archetti, Alberto Lleó, Marilyn S. Albert, László Vécsei, Mathias Jucker, Catherine Malaplate-Armand, Michael T. Heneka, Qiao-Xin Li, Daniela Galimberti, Karen H. Gylys, Xavier Parent, Igor Vostiar, Sebastiano Cavallaro, Silvana Gritti, Charlotte E. Teunissen, Ging-Yuek Robin Hsiung, Leslie M. Shaw, Roy B. Dyer, Daniele Bentue-Ferrer, Robert A. Rissman, Silvia Suardi, Ryozo Kuwano, Jose Luis Molinuevo, José Luis Molinuevo, C.E. Teunissen, Vara Luis Rello, Olivier Bousiges, Maria Berrocal Carrillo, Jordan Laser, Isabelle Quadrio, Neal Cutler, Stephan A. Käser, Marc Mercken, Sonia Chalbot, Niklas Mattsson, Giovanni B. Frisoni, Koen Poesen, Anne Fogli, Ulf Andreasson, Daniel Alcolea, Giuseppe Sancesario, Elisabeth Kapaki, Markus Otto, Aladro José A. Rojo, Khalid Iqbal, John Q. Trojanowski, Marinus A. Blankenstein, Jean-Louis Laplanche, Sergio Bernardini, Elisabetta Galloni, Inês Baldeiras, Hugo Vanderstichele, Kaj Blennow, Axel Regeniter, Colin L. Masters, Bradley T. Hyman, Holly Soares, Anna Antonell, Takeshi Iwatsubo, T. J. Montine, Steven J. Collins, Anne M. Fagan, Nick C. Fox, Daniel Kidd, Zdenek Rohan, Sebastiaan Engelborghs, Christin Sisowath, Péter Klivényi, Ronald C. Petersen, Bianca Van Broeck, Harald Hampel, Henrik Zetterberg, Hilkka Soininen, Maria C. Carrillo, Theresa Heath, Michael C. Camuso, Sanna-Kaisa Herukka, Johannes Schröder, Odile Delaroche, David M. Holtzman, William Nowatzke, Christian Humpel, Piotr Lewczuk, M.M. Verbeek, Piero Parchi, Foudil Lamari, D. Richard Lachno, Ales Bartos, Isabelle Cuvelier, Rik Vandenberghe, Sylvian Lehmann, Staffan Persson, Hanna Rosenmann, Manu Vandijck, Claude Jardel, Niels H. H. Heegaard, Anders Skinningsrud, Tiziana Casoli, Robert Martone, Dev Batish, Orestes Vicente Forlenza, Odete A. da Cruz e Silva, Diane Dufour-Rainfray

Publikováno v: Alzheimers & Dementia
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Alzheimer's & Dementia, 9, 3, pp. 251-61
Mattsson, N, Andreasson, U, Persson, S, Carrillo, M C, Collins, S, Chalbot, S, Cutler, N, Dufour-Rainfray, D, Fagan, A M, Heegaard, N H H, Hsiung, G Y R, Hyman, B, Iqbal, K, Lachno, D R, Lleo, A, Lewczuk, P, Molinuevo, J L, Parchi, P, Regeniter, A, Rissman, R, Rosenmann, H, Sancesario, G, Schroder, J, Shaw, L M, Teunissen, C E, Trojanowski, J Q, Vanderstichele, H, Vandijck, M, Verbeek, M M, Zetterberg, H, Blennow, K & Kaser, S A 2013, ' CSF biomarker variability in the Alzheimer's Association quality control program ', Alzheimers & Dementia, vol. 9, no. 3, pp. 251-261 . https://doi.org/10.1016/j.jalz.2013.01.010
Alzheimers & Dementia, 9(3), 251-261. Elsevier
Alzheimer's & Dementia, 9, 251-61

Background: The cerebrospinal fluid (CSF) biomarkers amyloid beta 1-42, total tau, and phosphorylated tau are used increasingly for Alzheimer's disease (AD) research and patient management. However, there are large variations in biomarker measurement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07db4b5c63c0d6762901958e135d4ac3
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=10085

The Nuclear Envelope Protein, LAP1B, Is a Novel Protein Phosphatase 1 Substrate

Autor: Paula J. M. van Kleeff, Sandra Rebelo, Connie E. Kim, Margarida Fardilha, Edgar F. da Cruz e Silva, William T. Dauer, Mariana Santos, Odete A. da Cruz e Silva

Publikováno v: research@ua; Vol 4 (2013); 30
research@ua; vol. 4 (2013); 30
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
PLoS ONE
PLoS ONE, Vol 8, Iss 10, p e76788 (2013)

Protein phosphatase 1 (PP1) binding proteins are quintessential regulators, determining substrate specificity and defining subcellular localization and activity of the latter. Here, we describe a novel PP1 binding protein, the nuclear membrane protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa609ce92c856440dc7b0ecdad12e7a5
https://doi.org/10.1371/journal.pone.0076788