SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability

Autor: Eleonora Petti, Valentina Buemi, Antonina Zappone, Odessa Schillaci, Pamela Veneziano Broccia, Roberto Dinami, Silvia Matteoni, Roberta Benetti, Stefan Schoeftner

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

LncRNA TERRA forms RNA-DNA hybrids at telomere sites leading to telomere instability. Here the authors identify the RNA interacting factors NONO and SFPQ as proteins that interact with TERRA and telomere chromatin and reveal putative roles for these

Externí odkaz: https://doaj.org/article/f8f8d328c17a48d78dd6073e811e9d80

Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity

Autor: Odessa Schillaci, Simona Fontana, Francesca Monteleone, Simona Taverna, Maria Antonietta Di Bella, Dolores Di Vizio, Riccardo Alessandro

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)

Abstract The goal of this study was to understand if exosomes derived from high-metastatic cells may influence the behavior of less aggressive cancer cells and the properties of the endothelium. We found that metastatic colon cancer cells are able to

Externí odkaz: https://doaj.org/article/1cabf9b6d83b456498950df7b9d6b956

SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability

Autor: Odessa Schillaci, Stefan Schoeftner, Silvia Matteoni, Valentina Buemi, Roberto Dinami, Eleonora Petti, Roberta Benetti, Pamela Veneziano Broccia, Antonina Zappone

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications

In vertebrates, the telomere repeat containing long, non-coding RNA TERRA is prone to form RNA:DNA hybrids at telomeres. This results in the formation of R-loop structures, replication stress and telomere instability, but also contributes to alternat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1139f6767617aea0e6d8a6924098a4
https://doi.org/10.1038/s41467-019-08863-1

Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation

Autor: Roberto Giardino, Mauro Manno, Simona Taverna, Pierfrancesco Tassone, Angela De Luca, Milena Fini, Odessa Schillaci, Nicola Amodio, Gianluca Giavaresi, Riccardo Alessandro, Simona Fontana, Lavinia Raimondi, Alessandra Santoro, Flores Naselli, Giacomo De Leo, Daniele Bellavia, Samuele Raccosta

Publikováno v: Scopus-Elsevier
Oncotarget 6 (2015): 13772–13789. doi:10.18632/oncotarget.3830
info:cnr-pdr/source/autori:Raimondi L.; De Luca A.; Amodio N.; Manno M.; Raccosta S.; Taverna S.; Bellavia D.; Naselli F.; Fontana S.; Schillaci O.; Giardino R.; Fini M.; Tassone P.; Santoro A.; De Leo G.; Giavaresi G.; Alessandro R./titolo:Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation/doi:10.18632%2Foncotarget.3830/rivista:Oncotarget/anno:2015/pagina_da:13772/pagina_a:13789/intervallo_pagine:13772–13789/volume:6
Oncotarget

Bone disease is the most frequent complication in multiple myeloma (MM) resulting in osteolytic lesions, bone pain, hypercalcemia and renal failure. In MM bone disease the perfect balance between bone-resorbing osteoclasts (OCs) and bone-forming oste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b79df3d5a2d9e5723927bb6025ed7e0
http://hdl.handle.net/10447/126733

TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance.

Autor: Buemi, Valentina, Schillaci, Odessa, Santorsola, Mariangela, Bonazza, Deborah, Broccia, Pamela Veneziano, Zappone, Annie, Bottin, Cristina, Dell'Omo, Giulia, Kengne, Sylvie, Cacchione, Stefano, Raffa, Grazia Daniela, Piazza, Silvano, di Fagagna, Fabrizio d'Adda, Benetti, Roberta, Cortale, Maurizio, Zanconati, Fabrizio, Del Sal, Giannino, Schoeftner, Stefan

Publikováno v: Nature Communications; 4/28/2022, Vol. 13 Issue 1, p1-15, 15p