Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Odelia Shimshon"'
Autor:
Polina Denichenko, Maxim Mogilevsky, Antoine Cléry, Thomas Welte, Jakob Biran, Odelia Shimshon, Georgina D. Barnabas, Miri Danan-Gotthold, Saran Kumar, Eylon Yavin, Erez Y. Levanon, Frédéric H. Allain, Tamar Geiger, Gil Levkowitz, Rotem Karni
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Alternative splicing, critical for gene expression, is deregulated in many diseases. Here the authors develop decoy oligonucleotides to specifically downregulate splicing factors activity.
Externí odkaz:
https://doaj.org/article/56b48a0782e64173831607d2f384bb24
Autor:
Eylon Yavin, Eli Keshet, Adi Mogilevsky, Maxim Mogilevsky, Florian Heyd, Saran Kumar, Odelia Shimshon, Rotem Karni
Publikováno v:
Nucleic Acids Research
The gene encoding the kinase Mnk2 (MKNK2) is alternatively spliced to produce two isoforms—Mnk2a and Mnk2b. We previously showed that Mnk2a is downregulated in several types of cancer and acts as a tumor suppressor by activation of the p38–MAPK s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21daf7473fbab312032f0c80f371aa3
https://doi.org/10.1093/nar/gky921
https://doi.org/10.1093/nar/gky921
Publikováno v:
ChemBioChem. 19:1618-1624
Intrinsically disordered regions (IDRs) in proteins are highly abundant, but they are still commonly viewed as long stretches of polar, solvent-accessible residues. Here we show that the disordered C-terminal domain (CTD) of HIV-1 Rev has two subregi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32631528ceb6c56afc6dc8b08a3d434b
https://doi.org/10.1002/cbic.201800192
https://doi.org/10.1002/cbic.201800192
Autor:
Gil Levkowitz, Odelia Shimshon, Polina Denichenko, Antoine Cléry, Rotem Karni, Jakob Biran, Frédéric H.-T. Allain, Miri Danan-Gotthold, Maxim Mogilevsky, Saran Kumar, Eylon Yavin, Erez Y. Levanon, Tamar Geiger, Georgina D. Barnabas, Thomas Welte
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Alternative splicing, a fundamental step in gene expression, is deregulated in many diseases. Splicing factors (SFs), which regulate this process, are up- or down regulated or mutated in several diseases including cancer. To date, there are no inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9386b254657bddea24726eaa05e26ef
https://doi.org/10.1038/s41467-019-09523-0
https://doi.org/10.1038/s41467-019-09523-0
Autor:
Oded Livnah, Dorit Michaeli, Rachel Nechushtai, Yael Eisenberg-Domovich, Alexander Schug, Heiko Lammert, Patricia A. Jennings, John A. Zuris, Paul C. Whitford, Alexander Fish, Maria A. Luca, Melinda Roy, Dominique T. Capraro, José N. Onuchic, Odelia Shimshon
Publikováno v:
Proceedings of the National Academy of Sciences. 108:2240-2245
Regulation of protein function via cracking, or local unfolding and refolding of substructures, is becoming a widely recognized mechanism of functional control. Oftentimes, cracking events are localized to secondary and tertiary structure interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc7c01b5fde9d722e3fec674988f206
https://doi.org/10.1073/pnas.1019502108
https://doi.org/10.1073/pnas.1019502108