Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Oddone Schiavon"'
Autor:
Isabella Monia Montagner, Katia Maso, Antonella Grigoletto, Oddone Schiavon, Gianfranco Pasut, Antonio Rosato
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 142:49-60
Antibody drug conjugates (ADCs), which are obtained by coupling a potent cytotoxic agent to a monoclonal antibody (mAb), are traditionally bound in a random way to lysine or cysteine residues, with the final product’s heterogeneity having an import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e61d82c03243ba634962b9445f357b5d
https://doi.org/10.1016/j.ejpb.2019.06.012
https://doi.org/10.1016/j.ejpb.2019.06.012
Publikováno v:
Macromolecular Bioscience. 16:50-56
The use of therapeutic proteins is often impaired by their short in vivo half-lives. PEGylation has been exploited to enhance protein stability and to prolong the pharmacokinetic. The biophysical characterization of two site-specific mono-PEGylated f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e406bd9b2d6f9edaffaf2f6c57357a9f
https://doi.org/10.1002/mabi.201500282
https://doi.org/10.1002/mabi.201500282
Publikováno v:
Journal of drug targeting. 25(9-10)
Microbial transglutaminase enzyme (mTGase) is an extremely useful enzyme that is increasingly employed in the food and pharmaceutical industries and as a tool for protein modification and tagging. The current study describes how we immobilised mTGase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50cbdd808ba8a8e51f58df0be3a4a88c
https://pubmed.ncbi.nlm.nih.gov/28805084
https://pubmed.ncbi.nlm.nih.gov/28805084
Publikováno v:
International Journal of Pharmaceutics. 454:653-659
Paclitaxel has been found to be very effective against several human cancers; one of the major problems with its use is its poor solubility, which makes necessary its solubilization with excipients that can determine allergic reactions often severe.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3928d5c204efb3a8a700beea1258226
https://doi.org/10.1016/j.ijpharm.2013.05.027
https://doi.org/10.1016/j.ijpharm.2013.05.027
The use of therapeutic proteins is often impaired by their short in vivo half-lives. PEGylation has been exploited to enhance protein stability and to prolong the pharmacokinetic. The biophysical characterization of two site-specific mono-PEGylated f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ca89e27dec49be980b711f57fd622c95
http://hdl.handle.net/11577/3183211
http://hdl.handle.net/11577/3183211
Autor:
Antonella Grigoletto, Antonio Rosato, Gianfranco Pasut, Katia Maso, Anna Mero, Oddone Schiavon
Drug and protein delivery techniques and methods, which, in most cases, are concurrently investigated from the very time a new molecular entity is proposed, have become valuable tools for the development of numerous therapeutic molecules. Attracting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69d1ba9357028821fe640ee46281c062
http://hdl.handle.net/11577/3183214
http://hdl.handle.net/11577/3183214
Autor:
Oddone Schiavon, Anna Mero, Gianfranco Pasut, Paolo Ferruti, Francesco M. Veronese, Elisa Emilitri
Publikováno v:
Journal of Bioactive and Compatible Polymers. 24:220-234
A biodegradable copolymer (PEG- fum), based on poly(ethylene glycol) (PEG) and fumarate ( fum) units, was synthesized and studied as a drug carrier. PEG and fum were linked together by ester bonds to confer biodegradability to the polymeric backbone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776105a913de8af53b6c169eead2f4d1
https://doi.org/10.1177/0883911509103783
https://doi.org/10.1177/0883911509103783
Autor:
Oddone Schiavon, Francesco M. Veronese, Roberto Mendichi, Gianfranco Pasut, Silvia Scaramuzza
Publikováno v:
Journal of Bioactive and Compatible Polymers. 20:213-230
PEG is used as a polymeric carrier for low molecular weight drugs, but limitations arise from the fact that only one or two hydroxyl residues are on each polymer. Therefore, the synthesis of dendrimeric structures, based on amino adipic acid or beta-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e2c3259d57d8474a1dea3ef485a7ad
https://doi.org/10.1177/0883911505053377
https://doi.org/10.1177/0883911505053377
Autor:
Antonio Rosato, Monica Campisi, Michele Caputo, Gianfranco Pasut, Oddone Schiavon, Anna Mero, Christian Cuppari
Publikováno v:
Current drug targets. 16(13)
Hyaluronic acid (HA) is a natural polysaccharide primarily present in the vitreous humor and in cartilages where it plays a key structural role in organizing the cartilage extracellular matrix. HA is used in a wide range of applications including tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdfd45504a50175f826d38fef2376f7
https://pubmed.ncbi.nlm.nih.gov/25563593
https://pubmed.ncbi.nlm.nih.gov/25563593
Autor:
Massimo Fresta, Oddone Schiavon, Donatella Paolino, Christian Celia, Haifa Shen, Joy Wolfram, Gianfranco Pasut, Donato Cosco, Anna Mero, Adrian Steve Joseph
Pegylation of nanoparticles has been widely implemented in the field of drug delivery to prevent macrophage clearance and increase drug accumulation at a target site. However, the shielding effect of polyethylene glycol (PEG) is usually incomplete an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee257c79978d9a4b7cfcf2fbba650bd
http://hdl.handle.net/11577/3100518
http://hdl.handle.net/11577/3100518