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Interleukin-1 Blockade in Recently Decompensated Systolic Heart Failure: Results From REDHART (Recently Decompensated Heart Failure Anakinra Response Trial).

Autor: Van Tassell BW; From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.)., Canada J; From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.)., Carbone S; From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.)., Trankle C; From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.)., Buckley L; From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.)., Oddi Erdle C; From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.)., Abouzaki NA; From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.)., Dixon D; From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.)., Kadariya D; From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.)., Christopher S; From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.)., Schatz A; From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.)., Regan J; From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.)., Viscusi M; From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.)., Del Buono M; From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.)., Melchior R; From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.)., Mankad P; From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.)., Lu J; From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.)., Sculthorpe R; From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.)., Biondi-Zoccai G; From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.)., Lesnefsky E; From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.)., Arena R; From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.)., Abbate A; From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.). antonio.abbate@vcuhealth.org.

Publikováno v: Circulation. Heart failure [Circ Heart Fail] 2017 Nov; Vol. 10 (11).