Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Odalys Gonzalez-Paz"'
Autor:
Annalise Di Marco, Domenico Vignone, Odalys Gonzalez Paz, Ivan Fini, Maria Rosaria Battista, Antonella Cellucci, Elena Bracacel, Giulio Auciello, Maria Veneziano, Vinod Khetarpal, Mark Rose, Alessandro Rosa, Isabelle Gloaguen, Edith Monteagudo, Todd Herbst, Celia Dominguez, Ignacio Muñoz-Sanjuán
Publikováno v:
Cells, Vol 9, Iss 4, p 994 (2020)
The blood-brain barrier (BBB) is responsible for the homeostasis between the cerebral vasculature and the brain and it has a key role in regulating the influx and efflux of substances, in healthy and diseased states. Stem cell technology offers the o
Externí odkaz:
https://doaj.org/article/d4344a862cc142e2914339bfced09308
Autor:
Domenico Vignone, Odalys Gonzalez Paz, Ivan Fini, Antonella Cellucci, Giulio Auciello, Maria Rosaria Battista, Isabelle Gloaguen, Silvia Fortuni, Cristina Cariulo, Vinod Khetarpal, Celia Dominguez, Ignacio Muñoz-Sanjuán, Annalise Di Marco
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 14; Pages: 7813
While blood–brain barrier (BBB) dysfunction has been described in neurological disorders, including Huntington’s disease (HD), it is not known if endothelial cells themselves are functionally compromised when promoting BBB dysfunction. Furthermor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a55c902a855245c8bcc46415b9585329
Autor:
Daniel Elbaum, Daniel O. Cicero, Paola Fezzardi, Annalise Di Marco, Steven J. Harper, Savina Malancona, Elena Bracacel, Andrea Vecchi, Ilaria Rossetti, Edith Monteagudo, Alina Ciammaichella, Giulio Auciello, Odalys Gonzalez Paz, Maria G. Beconi
Publikováno v:
Journal of Medicinal Chemistry. 63:15785-15801
Mutations in the human PANK2 gene are implicated in neurodegenerative diseases such as pantothenate kinase-associated neurodegeneration (PKAN) and result in low levels of coenzyme-A (CoA) in the CNS due to impaired production of phosphopantothenic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53c5a490a956c7c2db428b0dc609e43
https://doi.org/10.1021/acs.jmedchem.0c01531
https://doi.org/10.1021/acs.jmedchem.0c01531
Autor:
Mark Rose, Odalys Gonzalez Paz, Giulio Auciello, Annalise Di Marco, Todd Herbst, Ignacio Muñoz-Sanjuán, Domenico Vignone, Edith Monteagudo, Vinod Khetarpal, Matteo Zini, Maria Rosaria Battista, Laura Orsatti, Vincenzo Summa, Celia Dominguez, Leticia M Toledo-Sherman, Ivan Fini, Antonella Cellucci
Publikováno v:
Molecular Pharmaceutics. 16:2069-2082
Huntington's disease (HD) is a neurodegenerative disease caused by polyglutamine expansion in the huntingtin protein. For drug candidates targeting HD, the ability to cross the blood-brain barrier (BBB) and reach the site of action in the central ner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27cfdbc702df6685a64c4f15855675c2
https://doi.org/10.1021/acs.molpharmaceut.9b00042
https://doi.org/10.1021/acs.molpharmaceut.9b00042
Autor:
Ivan Fini, Maria Veneziano, Vinod Khetarpal, Elena Bracacel, Todd Herbst, Ignacio Munoz-Sanjuan, Mark Rose, Giulio Auciello, Edith Monteagudo, Alessandro Rosa, Celia Dominguez, Odalys Gonzalez Paz, Antonella Cellucci, Annalise Di Marco, Maria Rosaria Battista, Isabelle Gloaguen, Domenico Vignone
Publikováno v:
Cells
Volume 9
Issue 4
Cells, Vol 9, Iss 994, p 994 (2020)
Volume 9
Issue 4
Cells, Vol 9, Iss 994, p 994 (2020)
The blood-brain barrier (BBB) is responsible for the homeostasis between the cerebral vasculature and the brain and it has a key role in regulating the influx and efflux of substances, in healthy and diseased states. Stem cell technology offers the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a041cf35a29cb7bd1fddf8e63e91991e
http://hdl.handle.net/11573/1387940
http://hdl.handle.net/11573/1387940
Autor:
Cristina Gardelli, Uwe Koch, Odalys Gonzalez-Paz, Barbara Pacini, Claudio Giuliano, Renzo Bazzo, Vincenzo Pucci, Joseph F. Leone, Kenneth A. Koeplinger, Michael Rowley, Frank Narjes, Sergio Altamura, Fabrizio Fiore, Malte Meppen, Ralph Laufer, Annalise Di Marco
Publikováno v:
European Journal of Medicinal Chemistry. 44:3765-3770
The currently approved treatment for hepatitis C virus infections is a combination of Ribavirin and pegylated Interferon. It leads to a sustained virologic response in approximately only half of the patients treated. For this reason there is an urgen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93077b6796954614acb74a771114aabe
https://doi.org/10.1016/j.ejmech.2009.04.043
https://doi.org/10.1016/j.ejmech.2009.04.043
Autor:
Fabrizio Fiore, Michael Rowley, Philip Jones, Odalys Gonzalez Paz, Massimiliano Fonsi, Edith Monteagudo, Olaf Kinzel, Carsten Schultz-Fademrecht, Christian Steinkühler, Giovanna Pescatore, Laura Llauger-Bufi
Publikováno v:
Journal of Medicinal Chemistry. 52:3453-3456
The optimization of a potent, class I selective ketone HDAC inhibitor is shown. It possesses optimized pharmacokinetic properties in preclinical species, has a clean off-target profile, and is negative in a microbial mutagenicity (Ames) test. In a mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdcfe67490c8eaffda7f94edfef89fdb
https://doi.org/10.1021/jm9004303
https://doi.org/10.1021/jm9004303
Autor:
Odalys Gonzalez Paz, Stefania Lamartina, Hermann Bujard, Danilo R. Casimiro, Gennaro Ciliberto, John W. Shiver, Guiseppe Roscilli, Mary Ellen Davies, Stefano Colloca, Cira Daniela Rinaudo, Adam J. Simon, Luisa Silvi, Carlo Toniatti, Elena Fattori, Riccardo Cortese, Immacolata Zampaglione, Ralph Laufer
Publikováno v:
Molecular Therapy. 7:271-280
The tetracycline (Tc)-dependent system in its "on" version (rtTA system) displays a baseline activity in the uninduced state, severely limiting its potential applicability in human gene therapy. So far, two different strategies to circumvent this lim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87867678834eeb73cfd76fc874220fb
https://doi.org/10.1016/s1525-0016(02)00051-5
https://doi.org/10.1016/s1525-0016(02)00051-5
Autor:
Fabio Palombo, Paola Delmastro, Luigi Aurisicchio, Gennaro Ciliberto, Odalys Gonzalez Paz, Valentina Salucci, Nicola La Monica, Patrizia Rovere
Publikováno v:
Journal of Virology. 74:4816-4823
The current therapy for hepatitis B and C is based on systemic administration of recombinant human alpha interferon (r-hIFN-alpha). However, systemic delivery of r-hIFN-alpha is associated with severe side effects, but more importantly, it is effecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d1efccca8f4b706b1e8fd8a7f010a3
https://doi.org/10.1128/jvi.74.10.4816-4823.2000
https://doi.org/10.1128/jvi.74.10.4816-4823.2000
Autor:
Giorgio Minotti, Odalys Gonzalez Paz, Pierantonio Menna, Jack W Singer, Elvio Covino, Massimo Chello, Emanuela Salvatorelli
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 344(2)
Cardiotoxicity from the antitumor anthracycline doxorubicin correlates with doxorubicin cardiac levels, redox activation to superoxide anion (O(2)(.-)) and hydrogen peroxide (H(2)O(2)), and formation of the long-lived secondary alcohol metabolite dox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3a63d868bbfd0d9e191faa11e81bf2
https://pubmed.ncbi.nlm.nih.gov/23192654
https://pubmed.ncbi.nlm.nih.gov/23192654