Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Octavia Goodwin"'
Autor:
Houjian Cai, Scott D. Pegan, Iryna Lebedyeva, Alicja Bielawska, Zdzislaw M. Szulc, James S. Norris, Y. George Zheng, Zanna Beharry, Thomas Albers, Aiping Bai, Zhen Han, Essilvo Sulejmani, Qianjin Li, Octavia Goodwin, Omar Awad Alsaidan, Sungjin Kim
Figure S1. Knockdown of NMT1 by shRNA-NMT1 inhibits Src myristoylation and proliferation of prostate cancer cells. Figure S2. Knockdown of Src and Fyn kinase inhibits the growth of prostate cancer cells. Figure S3. The contribution of myristoylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278376ee2ab1a539f486aaacd526a3d0
https://doi.org/10.1158/0008-5472.22416945
https://doi.org/10.1158/0008-5472.22416945
Autor:
Houjian Cai, Scott D. Pegan, Iryna Lebedyeva, Alicja Bielawska, Zdzislaw M. Szulc, James S. Norris, Y. George Zheng, Zanna Beharry, Thomas Albers, Aiping Bai, Zhen Han, Essilvo Sulejmani, Qianjin Li, Octavia Goodwin, Omar Awad Alsaidan, Sungjin Kim
Data collection and refinement statistics (molecular replacement)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdfaaea0e4d61af9d6f5471820be0f13
https://doi.org/10.1158/0008-5472.22416924.v1
https://doi.org/10.1158/0008-5472.22416924.v1
Autor:
Houjian Cai, Scott D. Pegan, Iryna Lebedyeva, Alicja Bielawska, Zdzislaw M. Szulc, James S. Norris, Y. George Zheng, Zanna Beharry, Thomas Albers, Aiping Bai, Zhen Han, Essilvo Sulejmani, Qianjin Li, Octavia Goodwin, Omar Awad Alsaidan, Sungjin Kim
Loss of myristoylation in Src kinase inhibits its interaction with androgen receptor (AR) and activation of AR down-stream signaling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52beac319bff9c691e689b287eb25010
https://doi.org/10.1158/0008-5472.22416939
https://doi.org/10.1158/0008-5472.22416939
Autor:
Houjian Cai, Scott D. Pegan, Iryna Lebedyeva, Alicja Bielawska, Zdzislaw M. Szulc, James S. Norris, Y. George Zheng, Zanna Beharry, Thomas Albers, Aiping Bai, Zhen Han, Essilvo Sulejmani, Qianjin Li, Octavia Goodwin, Omar Awad Alsaidan, Sungjin Kim
Figure S6. Expression and purification of NMT1. Figure S7. Kinetic analysis of purified NMT1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1bf194090aac2c02cd78524e30026b
https://doi.org/10.1158/0008-5472.22416936.v1
https://doi.org/10.1158/0008-5472.22416936.v1
Autor:
Houjian Cai, Scott D. Pegan, Iryna Lebedyeva, Alicja Bielawska, Zdzislaw M. Szulc, James S. Norris, Y. George Zheng, Zanna Beharry, Thomas Albers, Aiping Bai, Zhen Han, Essilvo Sulejmani, Qianjin Li, Octavia Goodwin, Omar Awad Alsaidan, Sungjin Kim
Figure S8. Identifying compounds inhibiting Src myristoylation by Click chemistry. Figure S9. Structures and/or IC50 values of LCL and GRU compounds. Figure S10. Loss of myristoylation inhibits the localization of Src kinase at the cytoplasmic membra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aed30752b75ca7fadd92ad823e54a51
https://doi.org/10.1158/0008-5472.22416933.v1
https://doi.org/10.1158/0008-5472.22416933.v1
Autor:
Houjian Cai, Scott D. Pegan, Iryna Lebedyeva, Alicja Bielawska, Zdzislaw M. Szulc, James S. Norris, Y. George Zheng, Zanna Beharry, Thomas Albers, Aiping Bai, Zhen Han, Essilvo Sulejmani, Qianjin Li, Octavia Goodwin, Omar Awad Alsaidan, Sungjin Kim
Supplemental Methods and Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f139eb86d81dc5509ca44dd7d61dc30
https://doi.org/10.1158/0008-5472.22416930
https://doi.org/10.1158/0008-5472.22416930
Autor:
Houjian Cai, Scott D. Pegan, Iryna Lebedyeva, Alicja Bielawska, Zdzislaw M. Szulc, James S. Norris, Y. George Zheng, Zanna Beharry, Thomas Albers, Aiping Bai, Zhen Han, Essilvo Sulejmani, Qianjin Li, Octavia Goodwin, Omar Awad Alsaidan, Sungjin Kim
Primer sequences used for cloning Src/Fyn mutants, shRNAs, and RT-PCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab2b54246cf95d5b3a8cff892d9b8c2
https://doi.org/10.1158/0008-5472.22416927.v1
https://doi.org/10.1158/0008-5472.22416927.v1
Autor:
Houjian Cai, Scott D. Pegan, Iryna Lebedyeva, Alicja Bielawska, Zdzislaw M. Szulc, James S. Norris, Y. George Zheng, Zanna Beharry, Thomas Albers, Aiping Bai, Zhen Han, Essilvo Sulejmani, Qianjin Li, Octavia Goodwin, Omar Awad Alsaidan, Sungjin Kim
Protein N-myristoylation enables localization to membranes and helps maintain protein conformation and function. N-myristoyltransferases (NMT) catalyze co- or posttranslational myristoylation of Src family kinases and other oncogenic proteins, thereb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8574a644a2eb8a7fbd98842464c2b74d
https://doi.org/10.1158/0008-5472.c.6509691
https://doi.org/10.1158/0008-5472.c.6509691
Autor:
Houjian Cai, Scott D. Pegan, Iryna Lebedyeva, Alicja Bielawska, Zdzislaw M. Szulc, James S. Norris, Y. George Zheng, Zanna Beharry, Thomas Albers, Aiping Bai, Zhen Han, Essilvo Sulejmani, Qianjin Li, Octavia Goodwin, Omar Awad Alsaidan, Sungjin Kim
Figure S11. The myristoyl-CoA analog, B13 has limited effect in PNT2 normal prostate cells and 293T cells. Figure S12. The additive effect of B13 with knockdown of Src kinase in regulating proliferation of 22Rv1 and PC-3 cells. Figure S13. Effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de795f07e23a5a51ec357aae603973e
https://doi.org/10.1158/0008-5472.22416942
https://doi.org/10.1158/0008-5472.22416942