A pilot study of golexanolone, a new GABA-A receptor-modulating steroid antagonist, in patients with covert hepatic encephalopathy.

Autor: Montagnese S; University of Padova, Padova, Italy., Lauridsen M; Hospital of South West Jutland, Esbjerg, Denmark., Vilstrup H; Aarhus University, Aarhus, Denmark., Zarantonello L; University of Padova, Padova, Italy., Lakner G; CRU Hungary Kft., Miskolc, Hungary., Fitilev S; State Budgetary Healthcare Institution 'City Polyclinic №2', Moscow, Russia., Zupanets I; Clinical and Diagnostics Center, National University of Pharmacy, Kharkiv, Ukraine., Kozlova I; State Healthcare Institution 'Saratov Clinical Hospital #5', Saratov, Russia., Bunkova E; Medical University 'Reaviz', Samara, Russia., Tomasiewicz K; Department of Infectious Diseases and Hepatology, Medical University of Lublin, Poland., Berglund JE; CTC Clinical Trial Consultants AB, Uppsala, Sweden., Rorsman F; Dept of Gastroenterology and Hepatology, University Hospital Uppsala, Sweden., Hagström H; Unit of Hepatology, Department of Upper GI Diseases, Karolinska University Hospital, Stockholm, Sweden., Kechagias S; Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden., Ocklind CE; Dept of Gastroenterology, Västerås Hospital, Sweden., Mauney J; Array Biostatistics, Wilmington, NC, USA., Thunarf F; LINK Medical Research AB, Uppsala, Sweden., Mokhatarani M; Umecrine Cognition AB, Stockholm, Sweden., Bäckström T; Umecrine Cognition AB, Stockholm, Sweden; Department of Clinical Sciences, Obstetrics and Gynecology, Umeå University, SE-901 87 Umeå, Sweden., Doverskog M; Umecrine Cognition AB, Stockholm, Sweden., Lins LE; Umecrine Cognition AB, Stockholm, Sweden., Månsson M; Umecrine Cognition AB, Stockholm, Sweden., Samuelson P; Umecrine Cognition AB, Stockholm, Sweden., Nilsson D; Umecrine Cognition AB, Stockholm, Sweden., Schalling M; Umecrine Cognition AB, Stockholm, Sweden; Department of Molecular Medicine and Surgery and the Center for Molecular Medicine at Karolinska Institutet., Sweden., Johansson M; Umecrine Cognition AB, Stockholm, Sweden; Department of Clinical Sciences, Obstetrics and Gynecology, Umeå University, SE-901 87 Umeå, Sweden., Arlander E; Umecrine Cognition AB, Stockholm, Sweden., Scharschmidt BF; Umecrine Cognition AB, Stockholm, Sweden. Electronic address: bruce.scharschmidt@gmail.com.

Publikováno v: Journal of hepatology [J Hepatol] 2021 Jul; Vol. 75 (1), pp. 98-107. Date of Electronic Publication: 2021 Apr 21.