Safety and efficacy of dexpramipexole in eosinophilic asthma (EXHALE): a randomized controlled trial

Autor: Siddiqui, S, Wenzel, SE, Bozik, ME, Archibald, DG, Dworetzky, SI, Mather, JL, Killingsworth, R, Ghearing, N, Schwartz, JT, Ochkur, SI, Jacobsen, EA, Busse, WW, Panettieri, RA, Prussin, C

BACKGROUND: There is a need for new and effective oral asthma therapies. Dexpramipexole, an oral eosinophil-lowering drug, has not previously been studied in asthma. OBJECTIVE: We sought to evaluate the safety and efficacy of dexpramipexole in loweri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::73e260c767a588262a5d5e8485d79e67
http://hdl.handle.net/10044/1/105271

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Eosinophil Peroxidase: A Biomarker for Eosinophilic Chronic Rhinosinusitis Agnostic of Polyp Status.

Autor: Idler BM; Mayo Clinic Alix School of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA., Iijima K; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, Arizona, USA., Ochkur SI; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, Arizona, USA., Jacobsen EA; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, Arizona, USA., Rank MA; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, Arizona, USA.; Department of Otorhinolaryngology-Head and Neck Surgery, Mayo Clinic Arizona, Phoenix, Arizona, USA., Kita H; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, Arizona, USA.; Department of Otorhinolaryngology-Head and Neck Surgery, Mayo Clinic Arizona, Phoenix, Arizona, USA., Lal D; Department of Otorhinolaryngology-Head and Neck Surgery, Mayo Clinic Arizona, Phoenix, Arizona, USA.

Publikováno v: The Laryngoscope [Laryngoscope] 2024 Jan; Vol. 134 (1), pp. 69-78. Date of Electronic Publication: 2023 May 31.

Eosinophils promote effector functions of lung group 2 innate lymphoid cells in allergic airway inflammation in mice.

Autor: LeSuer WE; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, Ariz., Kienzl M; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Ochkur SI; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, Ariz., Schicho R; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Doyle AD; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, Ariz., Wright BL; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, Ariz; Division of Pulmonology, Phoenix Children's Hospital, Phoenix, Ariz., Rank MA; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, Ariz; Division of Pulmonology, Phoenix Children's Hospital, Phoenix, Ariz., Krupnick AS; Department of Surgery, University of Maryland, Baltimore, Md., Kita H; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, Ariz; Department of Immunology, Mayo Clinic Arizona, Scottsdale, Ariz., Jacobsen EA; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, Ariz; Department of Immunology, Mayo Clinic Arizona, Scottsdale, Ariz. Electronic address: jacobsen.elizabeth@mayo.edu.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2023 Aug; Vol. 152 (2), pp. 469-485.e10. Date of Electronic Publication: 2023 Apr 06.