CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells.

Autor: Rathore U; Gladstone Institutes, San Francisco, California, USA.; Department of Microbiology and Immunology, University of California, San Francisco, California, USA.; Innovative Genomics Institute, University of California, Berkeley, California, USA., Haas P; Gladstone Institutes, San Francisco, California, USA.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, California, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA., Easwar Kumar V; Gladstone Institutes, San Francisco, California, USA.; Department of Microbiology and Immunology, University of California, San Francisco, California, USA.; Innovative Genomics Institute, University of California, Berkeley, California, USA., Hiatt J; Gladstone Institutes, San Francisco, California, USA.; Department of Microbiology and Immunology, University of California, San Francisco, California, USA.; Innovative Genomics Institute, University of California, Berkeley, California, USA.; Medical Scientist Training Program, University of California, San Francisco, California, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, California, USA., Haas KM; Gladstone Institutes, San Francisco, California, USA.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, California, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA., Bouhaddou M; Gladstone Institutes, San Francisco, California, USA.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, California, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA., Swaney DL; Gladstone Institutes, San Francisco, California, USA.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, California, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA., Stevenson E; Gladstone Institutes, San Francisco, California, USA.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, California, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA., Zuliani-Alvarez L; Gladstone Institutes, San Francisco, California, USA.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, California, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA., McGregor MJ; Gladstone Institutes, San Francisco, California, USA.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, California, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA., Turner-Groth A; Gladstone Institutes, San Francisco, California, USA., Ochieng' Olwal C; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Accra, Ghana.; Department of Biochemistry, Cell & Molecular Biology, College of Basic & Applied Sciences, University of Ghana, Accra, Ghana., Bediako Y; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Accra, Ghana.; Department of Biochemistry, Cell & Molecular Biology, College of Basic & Applied Sciences, University of Ghana, Accra, Ghana., Braberg H; Gladstone Institutes, San Francisco, California, USA.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, California, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA., Soucheray M; Gladstone Institutes, San Francisco, California, USA.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, California, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA., Ott M; Gladstone Institutes, San Francisco, California, USA., Eckhardt M; Gladstone Institutes, San Francisco, California, USA.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, California, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA., Hultquist JF; Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Center for Pathogen Genomics and Microbial Evolution, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Marson A; Gladstone Institutes, San Francisco, California, USA.; Department of Microbiology and Immunology, University of California, San Francisco, California, USA.; Innovative Genomics Institute, University of California, Berkeley, California, USA.; Department of Medicine, University of California, San Francisco, California, USA.; Diabetes Center, University of California, San Francisco, California, USA.; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, California, USA.; Institute for Human Genetics, University of California, San Francisco, California, USA., Kaake RM; Gladstone Institutes, San Francisco, California, USA.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, California, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA., Krogan NJ; Gladstone Institutes, San Francisco, California, USA.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, California, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA.

Publikováno v: MBio [mBio] 2024 Apr 10; Vol. 15 (4), pp. e0222223. Date of Electronic Publication: 2024 Feb 27.