Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging.

Autor: Occean JR; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD, USA., Yang N; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD, USA., Sun Y; Department of Biochemistry, Albert Einstein School of Medicine, Bronx, NY, USA., Dawkins MS; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD, USA., Munk R; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD, USA., Belair C; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD, USA., Dar S; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD, USA., Anerillas C; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD, USA., Wang L; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD, USA., Shi C; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD, USA., Dunn C; Flow Cytometry Unit, National Institute on Aging, NIH, Baltimore, MD, USA., Bernier M; Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA., Price NL; Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA., Kim JS; Department of Biochemistry, Albert Einstein School of Medicine, Bronx, NY, USA., Cui CY; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD, USA., Fan J; Computational Biology and Genomics Core, Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD, USA., Bhattacharyya M; Department of Pharmacology, Yale University, New Haven, CT, USA., De S; Computational Biology and Genomics Core, Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD, USA., Maragkakis M; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD, USA., de Cabo R; Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA., Sidoli S; Department of Biochemistry, Albert Einstein School of Medicine, Bronx, NY, USA., Sen P; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD, USA. payel.sen@nih.gov.

Publikováno v: Nature communications [Nat Commun] 2024 Jul 28; Vol. 15 (1), pp. 6357. Date of Electronic Publication: 2024 Jul 28.

A hyper-quiescent chromatin state formed during aging is reversed by regeneration.

Autor: Yang N; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Occean JR; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Melters DP; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 21224, USA., Shi C; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Wang L; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Stransky S; Department of Biochemistry, Albert Einstein School of Medicine, Bronx, NY 10461, USA., Doyle ME; Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Cui CY; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Delannoy M; JHU SOM Microscope Facility, Johns Hopkins University, Baltimore, MD 21205, USA., Fan J; Computational Biology and Genomics Core, Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Slama E; Department of Surgery, Ascension Saint Agnes Hospital, Baltimore, MD 21229, USA., Egan JM; Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD 21224, USA., De S; Computational Biology and Genomics Core, Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Cunningham SC; Department of Surgery, Ascension Saint Agnes Hospital, Baltimore, MD 21229, USA., de Cabo R; Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Sidoli S; Department of Biochemistry, Albert Einstein School of Medicine, Bronx, NY 10461, USA., Dalal Y; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 21224, USA., Sen P; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA. Electronic address: payel.sen@nih.gov.

Publikováno v: Molecular cell [Mol Cell] 2023 May 18; Vol. 83 (10), pp. 1659-1676.e11. Date of Electronic Publication: 2023 Apr 27.

DNA methylation of Nuclear Factor of Activated T Cells 1 mediates the prospective relation between exposure to different traumatic event types and post-traumatic stress disorder.

Autor: Occean JR; Genomics Program, College of Public Health, University of South Florida, Tampa, FL, USA; Present address: Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Wani AH; Genomics Program, College of Public Health, University of South Florida, Tampa, FL, USA., Donglasan J; Genomics Program, College of Public Health, University of South Florida, Tampa, FL, USA., Aiello AE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Galea S; Boston University School of Public Health, Boston University, Boston, MA, USA., Koenen KC; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Psychiatric and Neurodevelopmental Genetics Unit & Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Qu A; Department of Statistics, University of California Irvine, Irvine, CA, USA., Wildman DE; Genomics Program, College of Public Health, University of South Florida, Tampa, FL, USA., Uddin M; Genomics Program, College of Public Health, University of South Florida, Tampa, FL, USA. Electronic address: monica43@usf.edu.

Publikováno v: Psychiatry research [Psychiatry Res] 2022 May; Vol. 311, pp. 114510. Date of Electronic Publication: 2022 Mar 19.

Epigenetic dysregulation in cardiovascular aging and disease.

Autor: Herman AB; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Occean JR; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Sen P; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.

Publikováno v: The journal of cardiovascular aging [J Cardiovasc Aging] 2021; Vol. 1. Date of Electronic Publication: 2021 Aug 23.