Výsledky vyhledávání - "Obukowicz, Mark G"

Electrospray/Tandem Mass Spectrometry for Quantitative Analysis of Lipid Remodeling in Essential Fatty Acid Deficient Mice

Autor: Obukowicz Mark G, J. J. Shieh, Kevin L. Duffin, Amiram Raz

Publikováno v: Analytical Biochemistry. 279:179-188

A method utilizing electrospray ionization coupled with tandem mass spectrometry was developed as a facile and rapid method to identify and quantify lipid remodeling in vivo. Electrospray/tandem mass spectrometric analyses were performed on lipids is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d7685c97d4217fc8f1095fa64202be
https://doi.org/10.1006/abio.1999.4452

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Dietary fish oil inhibits Δ6-desaturase activity in vivo

Autor: Amiram Raz, Nurit Kamin-Belsky, Fiorenza Przedecki, Obukowicz Mark G

Publikováno v: Journal of the American Oil Chemists' Society. 75:241-245

Liver Δ6-desaturase activity was determined in mice which were made deficient in (i) n-6 and n-3 polyunsaturated fatty acids (PUFA), (ii) n-6 PUFA, or (iii) arachidonic acid (AA). Initially, the mice were subjected to two cycles of a fasting (1 d)/r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2cdac9db41c12ef108d5592460af364
https://doi.org/10.1007/s11746-998-0037-4

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Fish oil inhibits Δ6 desaturase activity in vivo: Utility in a dietary paradigm to obtain mice depleted of arachidonic acid

Autor: Nurit Kamin-Belsky, Fiorenza Przedecki, Amiram Raz, Obukowicz Mark G

Publikováno v: The Journal of Nutritional Biochemistry. 8:558-565

In mice that were alternately fasted and then refed an essential fatty acid-deficient (EFAD) diet, there was a rapid and substantial decline in tissue n-3 and n-6 polyunsaturated fatty acids (PUFAs) and a corresponding increase in n-9 fatty acids. Co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2506b211542ff5bdb84a1883d6871273
https://doi.org/10.1016/s0955-2863(97)00086-7

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Dietary Epa Reduces Tumor Load in Apc Min/+ Mice by Altering Arachidonic Acid Metabolism, But Conjugated Linoleic Acid, Gamma- And Alpha-Linolenic Acids Have No Effect

Autor: Obukowicz Mark G, Melissa B. Hansen Petrik, Jay Whelan, Michael F. McEntee

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9781461349600

Colorectal cancer is the second leading cause of cancer deaths in the United States and several lines of evidence implicate environmental factors, specifically dietary components, as major variables influencing colorectal cancer incidence. Among thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ca91a73351ac58846395bd85a689a87
https://doi.org/10.1007/978-1-4615-0193-0_88

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Highly unsaturated (n-3) fatty acids, but not alpha-linolenic, conjugated linoleic or gamma-linolenic acids, reduce tumorigenesis in Apc(Min/+) mice

Autor: Jay Whelan, Melissa B. Hansen Petrik, Obukowicz Mark G, Benjamin T. Johnson, Michael F. McEntee

Publikováno v: The Journal of nutrition. 130(10)

We showed previously that dietary eicosapentaenoic acid [EPA, 20:5(n-3)] is antitumorigenic in the APC:(Min/+) mouse, a genetic model of intestinal tumorigenesis. Only a few studies have evaluated the effects of dietary fatty acids, including EPA and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a574c25026a6b2dd90ed85fba48ab4
https://pubmed.ncbi.nlm.nih.gov/11015469

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Identification and characterization of a novel delta6/delta5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent

Autor: Obukowicz Mark G, Jay M. Wendling, Paul D. Pyla, Amiram Raz, Joseph Gerace Rico, Philip Needleman

Publikováno v: Biochemical pharmacology. 55(7)

The anti-inflammatory properties of essential fatty acid deficiency or n-3 polyunsaturated fatty acid supplementation have been attributed to a reduced content of arachidonic acid (AA; 20:4 n-6). An alternative, logical approach to depleting AA would

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838520dd5f9448dc0f786ac64ae5854c
https://pubmed.ncbi.nlm.nih.gov/9605428

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Modulation of adjuvant-induced arthritis by dietary arachidonic acid in essential fatty acid-deficient rats

Autor: Obukowicz Mark G, Amiram Raz, William J. Salsgiver, Dean Welsch, Kevin Chinn, Aniali Mehta

Publikováno v: Lipids. 32(9)

Controlled feeding of linoleic acid (LA) or arachidonic acid (AA) to essential fatty acid-deficient (EFAD) rats was used to define the relationship between dietary AA and the inflammatory response evoked during adjuvant-induced arthritis. Based on en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7345bffe788616e0ca12e62a2265fcdc
https://pubmed.ncbi.nlm.nih.gov/9307941

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