PD-1 deficiency is not sufficient to induce myeloid mobilization to the brain or alter the inflammatory profile during chronic neurodegeneration

Autor: Obst, J., Mancuso, R., Simon, E., Gomez-Nicola, D.

Publikováno v: In Brain Behavior and Immunity October 2018 73:708-716

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PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages.

Autor: Obst J; Alzheimer's Research UK Oxford Drug Discovery Institute, Centre for Medicines Discovery, University of Oxford, Oxford, UK. juliane.obst@cmd.ox.ac.uk., Hall-Roberts HL; Alzheimer's Research UK Oxford Drug Discovery Institute, Centre for Medicines Discovery, University of Oxford, Oxford, UK.; James Martin Stem Cell Facility, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.; UK Dementia Research Institute (UK DRI) At Cardiff University, Cardiff, UK., Smith TB; Alzheimer's Research UK Oxford Drug Discovery Institute, Centre for Medicines Discovery, University of Oxford, Oxford, UK., Kreuzer M; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Institute of Pathology, University of Munich, Munich, Germany., Magno L; UCL Alzheimer's Research UK Drug Discovery Institute, London, UK., Di Daniel E; Alzheimer's Research UK Oxford Drug Discovery Institute, Centre for Medicines Discovery, University of Oxford, Oxford, UK.; Astex Pharmaceuticals, Cambridge, UK., Davis JB; Alzheimer's Research UK Oxford Drug Discovery Institute, Centre for Medicines Discovery, University of Oxford, Oxford, UK., Mead E; Alzheimer's Research UK Oxford Drug Discovery Institute, Centre for Medicines Discovery, University of Oxford, Oxford, UK.

Publikováno v: Scientific reports [Sci Rep] 2021 Oct 06; Vol. 11 (1), pp. 19842. Date of Electronic Publication: 2021 Oct 06.

Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology.

Autor: Hu Y; School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, UK., Fryatt GL; School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, UK., Ghorbani M; Antibody and Vaccine Group, Centre for Cancer Immunology, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK., Obst J; School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, UK., Menassa DA; School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, UK., Martin-Estebane M; School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, UK., Muntslag TAO; School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, UK., Olmos-Alonso A; School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, UK., Guerrero-Carrasco M; School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, UK., Thomas D; School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, UK., Cragg MS; Antibody and Vaccine Group, Centre for Cancer Immunology, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK., Gomez-Nicola D; School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, UK. Electronic address: d.gomez-nicola@soton.ac.uk.

Publikováno v: Cell reports [Cell Rep] 2021 Jun 08; Vol. 35 (10), pp. 109228.