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pro vyhledávání: '"Obst, Juliane"'
Autor:
Obst, Juliane1 (AUTHOR) juliane.obst@cmd.ox.ac.uk, Hall-Roberts, Hazel L.1,2,3 (AUTHOR), Smith, Thomas B.1 (AUTHOR), Kreuzer, Mira4,5 (AUTHOR), Magno, Lorenza6 (AUTHOR), Di Daniel, Elena1,7 (AUTHOR), Davis, John B.1 (AUTHOR), Mead, Emma1 (AUTHOR)
Publikováno v:
Scientific Reports. 10/6/2021, Vol. 11 Issue 1, p1-17. 17p.
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CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
Autor:
Mancuso, Renzo, Fryatt, Gemma, Cleal, Madeleine, Obst, Juliane, Pipi, Elena, Monzón-Sandoval, Jimena, Ribe, Elena, Winchester, Laura, Webber, Caleb, Nevado, Alejo, Jacobs, Tom, Austin, Nigel, Theunis, Clara, Grauwen, Karolien, Ruiz, Eva Daniela, Mudher, Amrit, Vicente-Rodriguez, Marta, Parker, Christine A., Simmons, Camilla, Cash, Diana, Richardson, Jill, Bullmore, Edward T., Bhatti, Junaid, Chamberlain, Samuel J., Correia, Marta M., Crofts, Anna L., Dickinson, Amber, Foster, Andrew C., Kitzbichler, Manfred G., Knight, Clare, Lynall, Mary-Ellen, Maurice, Christina, O'Donnell, Ciara, Pointon, Linda J., Hyslop, Peter St. George, Turner, Lorinda, Vertes, Petra, Widmer, Barry, Williams, Guy B., Morgan, B. Paul, Leckey, Claire A., Morgan, Angharad R., O'Hagan, Caroline, Touchard, Samuel, Cavanagh, Jonathan, Deith, Catherine, Farmer, Scott, McClean, John, McColl, Alison, McPherson, Andrew, Scouller, Paul, Sutherland, Murray, Boddeke, H. W. G. M. (Erik), Richardson, Jill C., Khan, Shahid, Murphy, Phil, Patel, Jai, Jones, Declan, de Boer, Peter, Kemp, John, Drevets, Wayne C., Nye, Jeffrey S., Wittenberg, Gayle, Isaac, John, Bhattacharya, Anindya, Carruthers, Nick, Kolb, Hartmuth, Pariante, Carmine M., Turkheimer, Federico, Barker, Gareth J., Byrom, Heidi, Cattaneo, Annamaria, Gee, Antony, Hastings, Caitlin, Mariani, Nicole, McLaughlin, Anna, Mondelli, Valeria, Nettis, Maria, Nikkheslat, Naghmeh, Randall, Karen, Sheridan, Hannah, Singh, Nisha, VAn Loo, Victoria, Wood, Tobias C, Worrell, Courtney, Zajkowska, Zuzanna, Plath, Niels, Egebjerg, Jan, Eriksson, Hans, Gastambide, Francois, Adams, Karen Husted, Jeggo, Ross, Thomsen, Christian, Pederson, Jan Torleif, Campbell, Brian, Möller, Thomas, Nelson, Bob, Zorn, Stevin, O'Connor, Jason, Attenburrow, Mary Jane, Baird, Alison, Benjamin, Jithen, Clare, Stuart, Cowen, Philip, Huang, I-Shu (Dante), Hurley, Samuel, Jones, Helen, Lovestone, Simon, Mada, Francisca, Nevado-Holgado, Alejo, Oladejo, Akintayo, Smith, Katy, Vyas, Anviti, Hughes, Zoe, Balice-Gordon, Rita, Duerr, James, Piro, Justin R, Sporn, Jonathan, Perry (PI), V Hugh, Gomez-Nicola, Diego, Reynolds, Richard, Harrison, Neil A., Cercignani, Mara, Clarke, Charlotte L, Hoskins, Elizabeth, Kohn, Charmaine, Murray, Rosemary, Wilcock, Lauren, Wlazly, Dominika, Mount, Howard, Jones, Declan N. C., Perry, V. Hugh
Neuroinflammation and microglial activation are significant processes in Alzheimer’s disease pathology. Recent genome-wide association studies have highlighted multiple immune-related genes in association with Alzheimer’s disease, and experimenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::51ba1226d0cdf9b948ae30e9b823a15b
https://orca.cardiff.ac.uk/id/eprint/125159/7/awz241.pdf
https://orca.cardiff.ac.uk/id/eprint/125159/7/awz241.pdf
Chronic inflammation is a major driver of neurodegenerative disease and immune regulatory pathways could be potential targets for therapeutic intervention. Recently, Programmed cell death-1 (PD-1) immune checkpoint inhibition has been proposed to mou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______348::c205b07983cc3be98ccc91f28d55da37
https://eprints.soton.ac.uk/422952/
https://eprints.soton.ac.uk/422952/
The understanding of the contribution of microglial cells to the onset and/or progression chronic neurodegenerative diseases is key to identify disease-modifying therapies, given the strong neuroimmune component of these disorders. In this review, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______348::6a7bd61a515b063c32578905d2783505
https://eprints.soton.ac.uk/417891/
https://eprints.soton.ac.uk/417891/
Inflammation is a major component of neurodegenerative diseases. Microglia are the innate immune cells in the central nervous system (CNS). In the healthy brain, microglia contribute to tissue homeostasis and regulation of synaptic plasticity. Under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______348::f0634bd5d8f610bbc99ec2780d9eeadb
https://eprints.soton.ac.uk/412302/
https://eprints.soton.ac.uk/412302/
Autor:
Obst, Juliane
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder which displays an inflammatory component characterized by the presence of pro- inflammatory cytokines. Previously, the hetero-dimeric cytokines interleukin- (IL-) 12 and IL-23 hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ab5146216564757f62c53a516f0730