Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Obinna Chijioke"'
Autor:
Lukas Egli, Meike Kaulfuss, Juliane Mietz, Arianna Picozzi, Els Verhoeyen, Christian Münz, Obinna Chijioke
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-18 (2024)
Abstract Background CAR NK cells as vehicles for engineered “off-the-shelf” cellular cancer immunotherapy have attracted significant interest. Nonetheless, a comprehensive comparative assessment of the anticancer activity of CAR T cells and CAR N
Externí odkaz:
https://doaj.org/article/8f50899e7813436a9d318bb05e27875d
Publikováno v:
EBioMedicine, Vol 106, Iss , Pp 105240- (2024)
Summary: Background: Humanized tumour models could be particularly valuable for cancer immunotherapy research, as they may better reflect human-specific aspects of the interfaces between tumour and immune system of human cancer. However, endogenous a
Externí odkaz:
https://doaj.org/article/97362e817bc54a9186814285396df9bd
Autor:
Florian Märkl, Christoph Schultheiß, Murtaza Ali, Shih-Shih Chen, Marina Zintchenko, Lukas Egli, Juliane Mietz, Obinna Chijioke, Lisa Paschold, Sebastijan Spajic, Anne Holtermann, Janina Dörr, Sophia Stock, Andreas Zingg, Heinz Läubli, Ignazio Piseddu, David Anz, Marcus Dühren-von Minden, Tianjiao Zhang, Thomas Nerreter, Michael Hudecek, Susana Minguet, Nicholas Chiorazzi, Sebastian Kobold, Mascha Binder
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The concept of precision cell therapy targeting tumor-specific mutations is appealing but requires surface-exposed neoepitopes, which is a rarity in cancer. B cell receptors (BCR) of mature lymphoid malignancies are exceptional in that they
Externí odkaz:
https://doaj.org/article/f556d70ecba646069501e54817da7995
Autor:
Meike Kaulfuss, Juliane Mietz, Astrid Fabri, Johannes vom Berg, Christian Münz, Obinna Chijioke
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Human natural killer (NK) cells are cytotoxic effector cells that are increasingly harnessed in cancer immunotherapy. NKG2A/CD94 is an inhibitory receptor on NK cells that has established regulatory functions in the direct interaction with t
Externí odkaz:
https://doaj.org/article/70f5ce4c167d444a94c9bb1b31270e67
Autor:
Patrick C. Freitag, Meike Kaulfuss, Lea Flühler, Juliane Mietz, Fabian Weiss, Dominik Brücher, Jonas Kolibius, K. Patricia Hartmann, Sheena N. Smith, Christian Münz, Obinna Chijioke, Andreas Plückthun
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 120-132 (2023)
Clinical success in T cell therapy has stimulated widespread efforts to increase safety and potency and to extend this technology to solid tumors. Yet progress in cell therapy remains restricted by the limited payload capacity, specificity of target
Externí odkaz:
https://doaj.org/article/add16acf3bd84d4ca22dbca9f3182210
Autor:
Nicole Caduff, Donal McHugh, Lisa Rieble, Catherine S. Forconi, John M. Ong’echa, Peter O. Oluoch, Ana Raykova, Anita Murer, Michelle Böni, Lara Zuppiger, Thomas F. Schulz, David J. Blackbourn, Obinna Chijioke, Ann M. Moormann, Christian Münz
Publikováno v:
Cell Reports, Vol 35, Iss 5, Pp 109056- (2021)
Summary: Herpesvirus infections shape the human natural killer (NK) cell compartment. While Epstein-Barr virus (EBV) expands immature NKG2A+ NK cells, human cytomegalovirus (CMV) drives accumulation of adaptive NKG2C+ NK cells. Kaposi sarcoma-associa
Externí odkaz:
https://doaj.org/article/8daa87608142474f9b3ea06d42a3614a
Autor:
Ana Raykova, Paolo Carrega, Frank M. Lehmann, Robert Ivanek, Vanessa Landtwing, Isaak Quast, Jan D. Lünemann, Daniela Finke, Guido Ferlazzo, Obinna Chijioke, Christian Münz
Publikováno v:
Blood Advances, Vol 1, Iss 27, Pp 2679-2691 (2017)
Abstract: Type 3 innate lymphoid cells (ILC3s) fulfill protective functions at mucosal surfaces via cytokine production. Although their plasticity to become ILC1s, the innate counterparts of type 1 helper T cells, has been described previously, we re
Externí odkaz:
https://doaj.org/article/719cb6bbebc148f887d5b58086f1fa60
Autor:
Anita Murer, Julia Rühl, Andrea Zbinden, Riccarda Capaul, Wolfgang Hammerschmidt, Obinna Chijioke, Christian Münz
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
Externí odkaz:
https://doaj.org/article/74c0cda733d54bd1be3e74eda555cdea
Autor:
Anita Murer, Julia Rühl, Andrea Zbinden, Riccarda Capaul, Wolfgang Hammerschmidt, Obinna Chijioke, Christian Münz
Publikováno v:
mBio, Vol 10, Iss 1 (2019)
ABSTRACT The human persistent and oncogenic Epstein-Barr virus (EBV) was one of the first viruses that were described to express viral microRNAs (miRNAs). These have been proposed to modulate many host and viral functions, but their predominant role
Externí odkaz:
https://doaj.org/article/17ba25af3ced431bb075ce49fd4ca487
Autor:
Anita Murer, Donal McHugh, Nicole Caduff, Jens Kalchschmidt, Mario Barros, Andrea Zbinden, Riccarda Capaul, Gerald Niedobitek, Martin Allday, Obinna Chijioke, Christian Münz
Publikováno v:
PLoS Pathogens, Vol 14, Iss 4, p e1007039 (2018)
The oncogenic Epstein Barr virus (EBV) infects the majority of the human population and usually persists within its host for life without symptoms. The EBV oncoproteins nuclear antigen 3A (EBNA3A) and 3C (EBNA3C) are required for B cell transformatio
Externí odkaz:
https://doaj.org/article/e054a1a6897b42a29d7d03f0df147dd7