Regulation of developmentally controlled enhancer activity by extrinsic signals in normal and malignant cells: AP-1 at the centre.

Autor: Maytum A; Blood Cell Development Group, Novo Nordisk Foundation Center for Stem Cell Medicine, Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria 3052 Australia, Country., Obier N; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Cauchy P; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Bonifer C; Blood Cell Development Group, Novo Nordisk Foundation Center for Stem Cell Medicine, Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria 3052 Australia, Country.; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Publikováno v: Frontiers in epigenetics and epigenomics [Front Epigenet Epigenom] 2024 Sep 16; Vol. 2.

Transcriptional reprogramming by mutated IRF4 in lymphoma.

Autor: Schleussner N; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Biology of Malignant Lymphomas, 13125, Berlin, Germany.; Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 10117, Berlin, Germany.; Experimental and Clinical Research Center (ECRC), a joint cooperation between Charité and MDC, Berlin, Germany., Cauchy P; Max Planck Institute of Immunobiology and Epigenetics, 79108, Freiburg, Germany.; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.; University Medical Center Freiburg, 79106, Freiburg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany., Franke V; Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück-Center, Berlin, Germany., Giefing M; Institute of Human Genetics, Polish Academy of Sciences, Poznan, 60-479, Poland.; Institute of Human Genetics, Christian-Albrechts-University Kiel, 24105, Kiel, Germany., Fornes O; Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, V5Z 4H4, Canada., Vankadari N; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3000, Australia., Assi SA; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK., Costanza M; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Biology of Malignant Lymphomas, 13125, Berlin, Germany.; Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 10117, Berlin, Germany.; Experimental and Clinical Research Center (ECRC), a joint cooperation between Charité and MDC, Berlin, Germany., Weniger MA; Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, 45122, Essen, Germany., Akalin A; Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück-Center, Berlin, Germany., Anagnostopoulos I; Institute of Pathology, Universität Würzburg and Comprehensive Cancer Centre Mainfranken (CCCMF), Würzburg, Germany., Bukur T; TRON gGmbH - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Germany., Casarotto MG; Research School of Biology, The Australian National University, Canberra, ACT, Australia., Damm F; Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 10117, Berlin, Germany., Daumke O; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Structural Biology, 13125, Berlin, Germany., Edginton-White B; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK., Gebhardt JCM; Department of Physics, Institute of Biophysics, Ulm University, Ulm, Germany., Grau M; Department of Physics, University of Marburg, 35052, Marburg, Germany.; Medical Department A for Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany., Grunwald S; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Structural Biology, 13125, Berlin, Germany., Hansmann ML; Frankfurt Institute of Advanced Studies, Frankfurt am Main, Germany.; Institute for Pharmacology and Toxicology, Goethe University, Frankfurt am Main, Germany., Hartmann S; Dr. Senckenberg Institute of Pathology, Goethe University Frankfurt, Frankfurt am Main, Germany., Huber L; Max Planck Institute of Immunobiology and Epigenetics, 79108, Freiburg, Germany., Kärgel E; Signal Transduction in Tumor Cells, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany., Lusatis S; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Biology of Malignant Lymphomas, 13125, Berlin, Germany.; Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 10117, Berlin, Germany.; Experimental and Clinical Research Center (ECRC), a joint cooperation between Charité and MDC, Berlin, Germany., Noerenberg D; Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 10117, Berlin, Germany., Obier N; Max Planck Institute of Immunobiology and Epigenetics, 79108, Freiburg, Germany.; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK., Pannicke U; Institute for Transfusion Medicine, University of Ulm, Ulm, Germany., Fischer A; Institute of Human Genetics, Ulm University and Ulm University Medical Center, 89081, Ulm, Germany., Reisser A; Department of Physics, Institute of Biophysics, Ulm University, Ulm, Germany., Rosenwald A; Institute of Pathology, Universität Würzburg and Comprehensive Cancer Centre Mainfranken (CCCMF), Würzburg, Germany., Schwarz K; Institute for Transfusion Medicine, University of Ulm, Ulm, Germany.; Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service Baden-Württemberg-Hessen, Ulm, Germany., Sundararaj S; Research School of Biology, The Australian National University, Canberra, ACT, Australia., Weilemann A; Medical Department A for Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany., Winkler W; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Biology of Malignant Lymphomas, 13125, Berlin, Germany.; Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 10117, Berlin, Germany.; Experimental and Clinical Research Center (ECRC), a joint cooperation between Charité and MDC, Berlin, Germany., Xu W; Medical Department A for Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany., Lenz G; Medical Department A for Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany., Rajewsky K; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Immune Regulation and Cancer, 13125, Berlin, Germany., Wasserman WW; Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, V5Z 4H4, Canada., Cockerill PN; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK., Scheidereit C; Signal Transduction in Tumor Cells, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany., Siebert R; Institute of Human Genetics, Christian-Albrechts-University Kiel, 24105, Kiel, Germany.; Institute of Human Genetics, Ulm University and Ulm University Medical Center, 89081, Ulm, Germany., Küppers R; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, 45122, Essen, Germany., Grosschedl R; Max Planck Institute of Immunobiology and Epigenetics, 79108, Freiburg, Germany., Janz M; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Biology of Malignant Lymphomas, 13125, Berlin, Germany.; Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 10117, Berlin, Germany.; Experimental and Clinical Research Center (ECRC), a joint cooperation between Charité and MDC, Berlin, Germany., Bonifer C; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK., Mathas S; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Biology of Malignant Lymphomas, 13125, Berlin, Germany. stephan.mathas@charite.de.; Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 10117, Berlin, Germany. stephan.mathas@charite.de.; Experimental and Clinical Research Center (ECRC), a joint cooperation between Charité and MDC, Berlin, Germany. stephan.mathas@charite.de.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. stephan.mathas@charite.de.

Publikováno v: Nature communications [Nat Commun] 2023 Nov 07; Vol. 14 (1), pp. 6947. Date of Electronic Publication: 2023 Nov 07.

Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells.

Autor: Zhang YW; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.; International Max Planck Research School for Molecular and Cellular Biology (IMPRS-MCB), Freiburg, Germany., Mess J; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.; Spemann Graduate School for Biology and Medicine (SGBM), Freiburg, Germany.; Centre for Integrative Biological Signalling Studies (CIBSS), Freiburg, Germany., Aizarani N; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.; International Max Planck Research School for Molecular and Cellular Biology (IMPRS-MCB), Freiburg, Germany., Mishra P; Pharmaceutical Bioinformatics, University of Freiburg, Freiburg, Germany., Johnson C; Department of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Romero-Mulero MC; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Rettkowski J; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.; Spemann Graduate School for Biology and Medicine (SGBM), Freiburg, Germany., Schönberger K; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.; International Max Planck Research School for Molecular and Cellular Biology (IMPRS-MCB), Freiburg, Germany., Obier N; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Jäcklein K; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Woessner NM; Faculty of Biology, University of Freiburg, Freiburg, Germany.; Spemann Graduate School for Biology and Medicine (SGBM), Freiburg, Germany.; Centre for Integrative Biological Signalling Studies (CIBSS), Freiburg, Germany.; Signalling Research Center BIOSS, Freiburg, Germany., Lalioti ME; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Velasco-Hernandez T; Josep Carreras Leukemia Research Institute-Campus Clinic and Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain., Sikora K; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Wäsch R; Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medical, University of Freiburg, Freiburg, Germany., Lehnertz B; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Canada., Sauvageau G; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Canada., Manke T; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Menendez P; Signalling Research Center BIOSS, Freiburg, Germany.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.; Spanish Network for Cancer Research (CIBER-ONC)-ISCIII, Barcelona, Spain., Walter SG; Department of Orthopedic Surgery, University Hospital of Cologne, Cologne, Germany., Minguet S; Faculty of Biology, University of Freiburg, Freiburg, Germany.; Centre for Integrative Biological Signalling Studies (CIBSS), Freiburg, Germany.; Signalling Research Center BIOSS, Freiburg, Germany., Laurenti E; Department of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Günther S; Pharmaceutical Bioinformatics, University of Freiburg, Freiburg, Germany., Grün D; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.; Centre for Integrative Biological Signalling Studies (CIBSS), Freiburg, Germany.; Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-Universität, Würzburg, Germany.; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany., Cabezas-Wallscheid N; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. cabezas@ie-freiburg.mpg.de.; Centre for Integrative Biological Signalling Studies (CIBSS), Freiburg, Germany. cabezas@ie-freiburg.mpg.de.

Publikováno v: Nature cell biology [Nat Cell Biol] 2022 Jul; Vol. 24 (7), pp. 1038-1048. Date of Electronic Publication: 2022 Jun 20.

Publisher Correction: Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration.

Autor: Clapes T; Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Polyzou A; Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Prater P; Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.; International Max Planck Research School for Molecular and Cellular Biology (IMPRS-MCB), Freiburg, Germany., Sagar; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.; Department of Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Morales-Hernández A; Department of Hematology, St Jude Children's Research Hospital, Memphis, TN, USA., Ferrarini MG; Univ Lyon, INSA-Lyon, INRAE, BF2I, UMR0203, Villeurbanne, France., Kehrer N; Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Lefkopoulos S; Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.; International Max Planck Research School for Molecular and Cellular Biology (IMPRS-MCB), Freiburg, Germany., Bergo V; Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.; International Max Planck Research School for Molecular and Cellular Biology (IMPRS-MCB), Freiburg, Germany., Hummel B; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Obier N; Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Maticzka D; Department of Computer Science, University of Freiburg, Freiburg, Germany., Bridgeman A; Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Herman JS; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.; Würzburg Institute of Systems Immunology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany., Ilik I; Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Klaeylé L; Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Rehwinkel J; Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., McKinney-Freeman S; Department of Hematology, St Jude Children's Research Hospital, Memphis, TN, USA., Backofen R; Department of Computer Science, University of Freiburg, Freiburg, Germany.; Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany., Akhtar A; Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.; Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany., Cabezas-Wallscheid N; Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.; Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany., Sawarkar R; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.; Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany.; Medical Research Council (MRC), University of Cambridge, Cambridge, UK., Rebollo R; Univ Lyon, INSA-Lyon, INRAE, BF2I, UMR0203, Villeurbanne, France., Grün D; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.; Würzburg Institute of Systems Immunology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.; Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany., Trompouki E; Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. trompouki@ie-freiburg.mpg.de.; Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany. trompouki@ie-freiburg.mpg.de.

Publikováno v: Nature cell biology [Nat Cell Biol] 2021 Dec; Vol. 23 (12), pp. 1338.

Epigenetic frontiers: miRNAs, long non-coding RNAs and nanomaterials are pioneering to cancer therapy.

Autor: Prabhakaran, Rajkumar¹ (AUTHOR), Thamarai, Rajkumar² (AUTHOR), Sivasamy, Sivabalan¹ (AUTHOR), Dhandayuthapani, Sivanesan¹ (AUTHOR), Batra, Jyoti¹ (AUTHOR) Dean.research@santosh.ac.in, Kamaraj, Chinnaperumal³ (AUTHOR) kamarajc@srmist.edu.in, Karthik, Krishnasamy⁴ (AUTHOR), Shah, Mohd Asif^5,6,7 (AUTHOR) m.asif@kardan.edu.af, Mallik, Saurav^8,9 (AUTHOR) sauravmtech2@gmail.com

Publikováno v: Epigenetics & Chromatin. 10/16/2024, Vol. 17 Issue 1, p1-26. 26p.