Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Obiamiwe Umeh"'
1
Ceftolozane-tazobactam compared with levofloxacin in the treatment of complicated urinary-tract infections, including pyelonephritis: a randomised, double-blind, phase 3 trial (ASPECT-cUTI)
Autor: Obiamiwe Umeh, Rabih O. Darouiche, Judith N. Steenbergen, Florian M.E. Wagenlehner, Guojun Yuan
Publikováno v: The Lancet. 385:1949-1956
Summary Background Treatment of complicated urinary-tract infections is challenging due to rising antimicrobial resistance. We assessed the efficacy and safety of ceftolozane-tazobactam, a novel antibacterial with Gram-negative activity, in the treat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46277778cd58a2cd4c4b4cb7529dfc79
https://doi.org/10.1016/s0140-6736(14)62220-0
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2
Efficacy of ceftolozane/tazobactam against urinary tract and intra-abdominal infections caused by ESBL-producing Escherichia coli and Klebsiella pneumoniae: a pooled analysis of Phase 3 clinical trials
Autor: David L. Paterson, Jennifer A. Huntington, Ellie Hershberger, Daniel J Cloutier, Benjamin F. Miller, Myra W. Popejoy, Caleb A. Bliss, Obiamiwe Umeh, Keith S. Kaye, Judith N. Steenbergen
Publikováno v: The Journal of antimicrobial chemotherapy. 72(1)
The increase in infections caused by drug-resistant ESBL-producing Enterobacteriaceae (ESBL-ENT) is a global concern. The characteristics and outcomes of patients infected with ESBL-ENT were examined in a pooled analysis of Phase 3 clinical trials of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c79c5861ce3530908d3fdf15955c918
https://pubmed.ncbi.nlm.nih.gov/27707990
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3
Intrapulmonary penetration of ceftolozane/tazobactam and piperacillin/tazobactam in healthy adult subjects
Autor: Keith A. Rodvold, Jennifer A. Huntington, Obiamiwe Umeh, Mark H. Gotfried, Gurudatt Chandorkar
Publikováno v: Journal of Antimicrobial Chemotherapy. 67:2463-2469
Objectives Appropriate antibiotic exposure at the site of infection is important for clinically effective therapy. This study compared the epithelial lining fluid (ELF) penetration of ceftolozane/tazobactam, which has potent in vitro activity against
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e0a3469a3af89529c447087e10aaed
https://doi.org/10.1093/jac/dks246
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5
Efficacy and tolerability of IV doripenem versus meropenem in adults with complicated intra-abdominal infection: a phase III, prospective, multicenter, randomized, double-blind, noninferiority study
Autor: Joel Jiang, Ian Friedland, Abel Jasovich, Obiamiwe Umeh, Koné Kaniga, Christopher Lucasti
Publikováno v: Clinical therapeutics. 30(5)
Background: Complicated intra-abdominal infections (cIAIs) require surgical intervention and empiric antibacterial therapy. Doripenem, a broad-spectrum carbapenem, provides coverage of key gram-negative and -positive aerobes and anaerobes encountered
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85741305db42312c80dbfde6c0902c8d
https://pubmed.ncbi.nlm.nih.gov/19014850
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