Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Obiamaka Obianyo"'
Autor:
Zhentao Zhang, Obiamaka Obianyo, Elfriede Dall, Yuhong Du, Haian Fu, Xia Liu, Seong Su Kang, Mingke Song, Shan-Ping Yu, Chiara Cabrele, Mario Schubert, Xiaoguang Li, Jian-Zhi Wang, Hans Brandstetter, Keqiang Ye
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Delta-secretases are associated with Alzheimer’s disease (AD) as they cleave both amyloid precursor protein and tau. Here the authors develop a series of orally bioactive small molecule delta-secretase inhibitors and report its therapeutic effects
Externí odkaz:
https://doaj.org/article/af4749718ac94cb988dc9847eb692495
Autor:
Obiamaka Obianyo, Yan Liang, Ellen L Burnham, Ashish Mehta, Youngja Park, Karan Uppal, Frank L Harris, Dean P Jones, Lou Ann S Brown
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129570 (2015)
An alcohol use disorder (AUD) is associated with an increased susceptibility to respiratory infection and injury and, upon hospitalization, higher mortality rates. Studies in model systems show effects of alcohol on mitochondrial function, lipid meta
Externí odkaz:
https://doaj.org/article/569780ad97844f038103aa902eac7a74
Publikováno v:
Journal of Medicinal Chemistry. 60:7244-7255
Asparagine endopeptidase (AEP), also called legumain, is highly expressed in various solid tumors, promoting cancer cell invasion, migration, and metastasis. It has been proposed to be a prognostic marker and therapeutic target for cancer treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c732213b7bba7bf0042fe9480daef1b4
https://doi.org/10.1021/acs.jmedchem.7b00228
https://doi.org/10.1021/acs.jmedchem.7b00228
Autor:
Lyndsey M. Shaak, Benjamin R. Rupert, Aaron N. Jahn, Andrew R. Ehle, Jesse V. Walker, Karyn M. Usher, James M. Tocyloski, Maria J. Sanford, Kyle J. Spivack, Felix E. Goodson, Obiamaka Obianyo
Publikováno v:
The Journal of Organic Chemistry. 82:1301-1315
In this Article, we present a new method for the synthesis of diarylnorbornadiene derivatives. Through the use of a two-step procedure consisting of a tandem alkene insertion-Suzuki coupling reaction followed by a DDQ dehydrogenation, we have been ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad61abbe5f823bc56d717486ccf12170
https://doi.org/10.1021/acs.joc.6b02025
https://doi.org/10.1021/acs.joc.6b02025
Autor:
Obiamaka Obianyo, Mark M. Goodman, Fanxing Zeng, Junjian Huang, Jenny J. Yang, Xia Liu, Chi Bun Chan, Shenghui Xue, Keqiang Ye
Publikováno v:
Journal of Biological Chemistry. 289:27571-27584
7,8-dihydroxyflavone (7,8-DHF), a newly identified small molecular TrkB receptor agonist, rapidly activates TrkB in both primary neurons and the rodent brain and mimics the physiological functions of the cognate ligand BDNF. Accumulating evidence sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d696ebb4f631c79128f7926c740a46
https://doi.org/10.1074/jbc.m114.562561
https://doi.org/10.1074/jbc.m114.562561
Autor:
Obiamaka Obianyo, Paul R. Thompson
Publikováno v:
Journal of Biological Chemistry. 287:6062-6071
The protein arginine methyltransferases (PRMTs) are a family of enzymes that catalyze the mono- and dimethylation of arginine residues in a variety of proteins. Although these enzymes play important roles in a variety of cellular processes, aberrant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2927b322e525a10845743f69ca5d07
https://doi.org/10.1074/jbc.m111.333609
https://doi.org/10.1074/jbc.m111.333609
Publikováno v:
Mol. BioSyst.. 7:48-51
The dysregulation of protein arginine methyltransferases (PRMTs) is implicated in a wide variety of disease states. Here we report the design, synthesis, and screening of a combinatorial peptide library used to characterize the substrate specificity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff29e09222eb9f9d9933fe6613b970cf
https://doi.org/10.1039/c0mb00015a
https://doi.org/10.1039/c0mb00015a
Autor:
Justin E. Jones, Paul R. Thompson, Obiamaka Obianyo, Youngho Lee, Corey P. Causey, Michael R. Stallcup, Tanesha C. Osborne
Publikováno v:
ChemBioChem. 11:1219-1223
Protein arginine methyltransferases (PRMTs) catalyze the post-translational methylation of arginine residues. PRMT1 is the predominant mammalian isozyme, and is responsible for generating the majority of the asymmetrically dimethylated arginine found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4874ac1930a968418f87527b8986ca88
https://doi.org/10.1002/cbic.201000209
https://doi.org/10.1002/cbic.201000209
Publikováno v:
Biochemistry. 47:10420-10427
Protein arginine methyltransferases (PRMTs) are SAM-dependent enzymes that catalyze the mono- and di-methylation of peptidyl arginine residues. Although all PRMTs produce mono-methyl arginine (MMA), type 1 PRMTs go on to form asymmetrically dimethyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453db0e79acbbae6a21dc0122f9515ff
https://doi.org/10.1021/bi800904m
https://doi.org/10.1021/bi800904m
Autor:
Dean P. Jones, Obiamaka Obianyo, Karan Uppal, Youngja Park, Frank L. Harris, Lou Ann S. Brown, Yan Liang, Ellen L. Burnham, Ashish J. Mehta
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129570 (2015)
PLoS ONE
PLoS ONE
An alcohol use disorder (AUD) is associated with an increased susceptibility to respiratory infection and injury and, upon hospitalization, higher mortality rates. Studies in model systems show effects of alcohol on mitochondrial function, lipid meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7dd6fadc597b843efba5aa9deb0b8c4
http://europepmc.org/articles/PMC4477879?pdf=render
http://europepmc.org/articles/PMC4477879?pdf=render