Výsledky vyhledávání - "Obeticholic acid (OCA)"

Akademický článek

Computational study of novel natural agonists targeting farnesoid X receptor

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract The farnesoid X receptor (FXR) is a crucial therapeutic target for treating non-alcoholic steatohepatitis (NASH). Although obeticholic acid (OCA) as a FXR agonist presents good efficacy, the safety data such as severe pruritus should be care

Externí odkaz: https://doaj.org/article/454a6311bf3c4c40a22be314906d42dd

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Akademický článek

Bile acid interactions with neurotransmitter transporters

Autor: Tiziana Romanazzi, Daniele Zanella, Manan Bhatt, Angela Di Iacovo, Aurelio Galli, Elena Bossi

Publikováno v: Frontiers in Cellular Neuroscience, Vol 17 (2023)

Synthesized in the liver from cholesterol, the bile acids (BAs) primary role is emulsifying fats to facilitate their absorption. BAs can cross the blood-brain barrier (BBB) and be synthesized in the brain. Recent evidence suggests a role for BAs in t

Externí odkaz: https://doaj.org/article/c67a404e8fe5440f8027adfde41840e8

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Akademický článek

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Akademický článek

Obeticholic Acid Induces Hepatoxicity Via FXR in the NAFLD Mice

Autor: Chuangzhen Lin, Bingqing Yu, Lixin Chen, Zhaohui Zhang, Weixiang Ye, Hui Zhong, Wenke Bai, Yuping Yang, Biao Nie

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Objective: Obeticholic acid (OCA), a potent farnesoid X receptor (FXR) agonist, is a promising drug for nonalcoholic fatty liver disease (NAFLD); however, it can cause liver injury, especially at high doses. Here, we investigated the role of FXR in t

Externí odkaz: https://doaj.org/article/6beeb3451cb647cd8b67df5adea47177

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Akademický článek

Selected Aspects of the Intricate Background of Immune-Related Cholangiopathies—A Critical Overview

Autor: Beata Kasztelan-Szczerbinska, Anna Rycyk-Bojarzynska, Agnieszka Szczerbinska, Halina Cichoz-Lach

Publikováno v: Nutrients, Vol 15, Iss 3, p 760 (2023)

Primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) are rare immune-related cholangiopathies with still poorly explained pathogenesis. Although triggers of chronic inflammation with subsequent fibrosis that affect cholangiocyt

Externí odkaz: https://doaj.org/article/208b45e57f60431c970e5db57784d612

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Akademický článek

Update on the Pharmacological Treatment of Primary Biliary Cholangitis

Autor: Annarosa Floreani, Daniela Gabbia, Sara De Martin

Publikováno v: Biomedicines, Vol 10, Iss 8, p 2033 (2022)

Ursodeoxycholic acid (UDCA) is the first-line therapy used for the treatment of PBC. In recent years, new pharmacological agents have been proposed for PBC therapy to cure UDCA-non-responders. Obeticholic acid (OCA) is registered in many countries fo

Externí odkaz: https://doaj.org/article/c34f5e015ce24f7e8259bc13d9ea95c8

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Bile acid interactions with neurotransmitter transporters

Autor: Romanazzi, Tiziana, Zanella, Daniele, Bhatt, Manan, Di Iacovo, Angela, Galli, Aurelio, Bossi, Elena

Publikováno v: Frontiers in Cellular Neuroscience. 17

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de82197e0ea6eb460b6ff464f63a3537
https://doi.org/10.3389/fncel.2023.1161930

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Akademický článek

Metabolomic Study of High-Fat Diet-Induced Obese (DIO) and DIO Plus CCl4-Induced NASH Mice and the Effect of Obeticholic Acid

Autor: Nanlin Zhu, Suling Huang, Qingli Zhang, Zhuohui Zhao, Hui Qu, Mengmeng Ning, Ying Leng, Jia Liu

Publikováno v: Metabolites, Vol 11, Iss 6, p 374 (2021)

The pathophysiology of nonalcoholic fatty liver disease (NAFLD) is a complex process involving metabolic and inflammatory changes in livers and other organs, but the pathogenesis is still not well clarified. Two mouse models were established to study

Externí odkaz: https://doaj.org/article/6f4f60a9398143559f1eb323bbeba453

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Akademický článek

Obeticholic acid for the treatment of primary biliary cholangitis in adult patients: clinical utility and patient selection

Autor: Bowlus CL

Publikováno v: Hepatic Medicine: Evidence and Research, Vol Volume 8, Pp 89-95 (2016)

Christopher L Bowlus Division of Gastroenterology and Hepatology, University of California Davis, Davis, CA, USA Abstract: Primary biliary cholangitis (PBC), previously known as primary biliary “cirrhosis”, is a rare autoimmune liver disease char

Externí odkaz: https://doaj.org/article/02b78315543141608ce2fe1b8e43b326

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A consensus integrated care pathway for patients with primary biliary cholangitis: a guideline-based approach to clinical care of patients

Autor: Gideon M. Hirschfield, Femi Adekunle, Marco Carbone, Olivier Chazouillères, Helena Cortez-Pinto, Guilherme Macedo, Victor de Ledinghen

Publikováno v: Expert Review of Gastroenterology & Hepatology
Expert Review of Gastroenterology & Hepatology, Future Drugs, 2007-, 2021, pp.1-11. ⟨10.1080/17474124.2021.1945919⟩
Expert Review of Gastroenterology & Hepatology, 2021, pp.1-11. ⟨10.1080/17474124.2021.1945919⟩

© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6548d79972a10c5311e81e29090fbf
https://doi.org/10.1080/17474124.2021.1945919

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