Výsledky vyhledávání - "Obesity Studies"

Rapid Decline in β-Cell Function and Increasing Adiposity Are Associated With Conversion to Type 2 Diabetes in At-Risk Latino Youth

Autor: Alaina P. Vidmar, Ramon Durazo-Arvizu, Marc J. Weigensberg, Tanya L. Alderete, Michael I. Goran

Publikováno v: Diabetes

Youth-onset type 2 diabetes (T2D) is becoming increasingly prevalent, especially among Latino youth, and there is limited information on its pathophysiology and causative factors. Here, we describe findings from a longitudinal cohort study in 262 Lat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5752522987e916357d8abcf3492f41fa
https://doi.org/10.2337/db22-1034

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Genetic Predictors of Change in Waist Circumference and Waist-to-Hip Ratio With Lifestyle Intervention

Publikováno v: Diabetes, 71(4), 669-676. American Diabetes Association
Diabetes

Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) associated with waist circumference and waist-to-hip ratio adjusted for body mass index (WCadjBMI, WHRadjBMI), but it remains unclear whether these SNPs relate to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef6cf8ff8f3c299dedbc4ce6579c01d
https://doi.org/10.2337/db21-0741

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Sleep Disturbance and Changes in Energy Intake and Body Composition During Weight Loss in the POUNDS Lost Trial

Autor: Ang Li, Xiang Li, Tao Zhou, Hao Ma, Yoriko Heianza, Donald A. Williamson, Steven R. Smith, George A. Bray, Frank M. Sacks, Lu Qi

Publikováno v: Diabetes

To examine associations between sleep disturbance and changes in weight and body composition and the mediating role of changes of appetite and food cravings in the Preventing Overweight Using Novel Dietary Strategies (POUNDS Lost) 2-year weight-loss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7715812235a8b1ea5636408872cf5163
https://doi.org/10.2337/db21-0699

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Adipocyte-Specific Modulation of KLF14 Expression in Mice Leads to Sex-Dependent Impacts on Adiposity and Lipid Metabolism

Autor: Qianyi Yang, Jameson Hinkle, Jordan N. Reed, Redouane Aherrahrou, Zhiwen Xu, Thurl E. Harris, Erin J. Stephenson, Kiran Musunuru, Susanna R. Keller, Mete Civelek

Publikováno v: Diabetes

Genome-wide association studies identified single nucleotide polymorphisms on chromosome 7 upstream of KLF14 to be associated with metabolic syndrome traits and increased risk for Type 2 Diabetes (T2D). The associations were more significant in women

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f67b3860d7d8b8b6fd5b98ed8eed55
https://doi.org/10.2337/db21-0674

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Association between obesity and chronic kidney disease: multivariable Mendelian randomization analysis and observational data from a bariatric surgery cohort

Autor: Anthony Nguyen, Rana Khafagy, Yiding Gao, Ameena Meerasa, Delnaz Roshandel, Mehran Anvari, Boxi Lin, David Z.I. Cherney, Michael E. Farkouh, Baiju R. Shah, Andrew D. Paterson, Satya Dash

Publikováno v: Diabetes

Obesity is postulated to independently increase chronic kidney disease (CKD), even after adjusting for type 2 diabetes (T2D) and hypertension. Dysglycemia below T2D thresholds, frequently seen with obesity, also increases CKD risk. Whether obesity in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0015e5f22e9aba8f970a0a58ce7924ae
https://doi.org/10.2337/figshare.21913053.v1

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Sleeve Gastrectomy Suppresses Hepatic Glucose Production and Increases Hepatic Insulin Clearance Independent of Weight Loss

Autor: Anna Permyakova, Rachel Ben-Haroush Schyr, Joseph Tam, Ronit Grinbaum, Michael Bergel, Shahar Azar, Yhara Arad, Liron Hefetz, Botros Moalem, Hadar Israeli, Itia Magenheim, Aya Bardugo, Arnon Haran, Danny Ben-Zvi, Abbas Al-Kurd

Publikováno v: Diabetes

Bariatric operations induce weight loss, which is associated with an improvement in hepatic steatosis and a reduction in hepatic glucose production. It is not clear whether these outcomes are entirely due to weight loss, or whether the new anatomy im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84ed141be21cf5c20b6c79e22bce9a7c
http://europepmc.org/articles/PMC8576500

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Elektronická kniha

Chapter 3 How body size became a disease

Autor: Flegal, Katherine

Taller people tend to weigh more than shorter people. This chapter will interrogate how weight varies with height. The body mass index (BMI, calculated as weight (W) divided by height (H) squared) is one way to express weight adjusted for height. It

Externí odkaz: https://library.oapen.org/handle/20.500.12657/62884

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Placental Insulin/IGF-1 Signaling, PGC-1α, and Inflammatory Pathways Are Associated With Metabolic Outcomes at 4–6 Years of Age: The ECHO Healthy Start Cohort

Autor: Kristen E. Boyle, Katerina Kechris, Jacob E. Friedman, Kathryn Erickson, Harry A Smith, Ivana V. Yang, Dana Dabelea, Thomas Jansson, Madeline Rose Keleher

Publikováno v: Diabetes

An adverse intrauterine environment is associated with the future risk of obesity and type 2 diabetes. Changes in placental function may underpin the intrauterine origins of adult disease, but longitudinal studies linking placental function with chil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c07d05e09b817225114333f932966c6
https://doi.org/10.2337/db20-0902

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Lifestyle Intervention in Pregnant Women With Obesity Impacts Cord Blood DNA Methylation, Which Associates With Body Composition in the Offspring

Autor: Charlotte Ling, Kristina M Renault, Emma Malchau Carlsen, Mads Vendelbo Lind, Kirsten Nørgaard, Josefine Jönsson, Angela C. Estampador, Kim F. Michaelsen, Alexander Perfilyev, Allan Vaag, Paul W. Franks, Line Hjort, Sonia García-Calzón

Publikováno v: Diabetes

Maternal obesity may lead to epigenetic alterations in the offspring and might thereby contribute to disease later in life. We investigated whether a lifestyle intervention in pregnant women with obesity is associated with epigenetic variation in cor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ccb3f62015a817244c31fbf4ee5b52
http://europepmc.org/articles/PMC7980200

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Botulinum Injection into the Proximal Intestinal Wall of Diet-induced Obese Mice Leads to Weight Loss and Improves Glucose and Fat Tolerance

Autor: Sinju Sundaresan, Joseph Antoun, Babak Banan, Jamie Adcock, Connor Johnson, Brendan Claire, Kala Dixon, Joyce Flynn, Cyndya A. Shibao, Naji Abumrad

Publikováno v: Diabetes

Botulinum neurotoxin (available commercially as BOTOX®) has been used successfully for treatment of several neuromuscular disorders including blepharospasm, dystonia, spasticity, and cerebral palsy in children. Our data demonstrate that injection of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f25caf078ccf76b4b1c5049169040ad
https://doi.org/10.2337/figshare.19609992.v1

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