Výsledky vyhledávání - "Obesity Mechanisms and Treatments Potpourri"

MON-108 Dihydrotestosterone Lowers Cytosolic Sterol Regulatory Element-Binding Protein-1 in Adipose Tissue from Female Mice

Autor: Tina Seidu, Stanley Andrisse, Patrick McWhorter, Rabita Alamgir

Publikováno v: Journal of the Endocrine Society

Abstract: Hyperandrogenemia (HA) and insulin resistance (IR) are hallmarks of polycystic ovary syndrome (PCOS), a common endocrine disorder that affects roughly 1 in 5 women, according to the Rotterdam criteria. These hallmarks are also integral elem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0f4a4d68cfd81750acd2aa7feaa362
http://europepmc.org/articles/PMC6550965

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MON-LB016 Sex and Sex Steroid Effects on Brown Adipose Tissue Temperature in Healthy Humans

Autor: Helen Truby, Aimee L. Dordevic, John-Paul Fuller-Jackson, Iain J. Clarke, Belinda A. Henry

Publikováno v: Journal of the Endocrine Society

Retrospective studies indicate that women have more brown adipose tissue (BAT) than men. Furthermore, animal studies show that sex steroids modulate BAT activity, wherein estrogen increases BAT function. We aimed to characterize BAT thermogenesis usi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d046b31addfbb0d5646a789efea380
http://europepmc.org/articles/PMC6550798

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MON-LB020 Compound H Causes a Sustained Reduction in Food Intake and Body Weight in Obese Cynomolgus

Autor: Wong Peggy, Yuanping Wang, Chen Fei, Songmao Zheng, Geist Brian, Vedrana Stojanvic-Susulic, Andrea R Nawrocki, D’Aquino Katharine, Shamina M. Rangwala, Simon A. Hinke

Publikováno v: Journal of the Endocrine Society

Obesity is associated with increased risk of diabetes and cardiovascular disease. Evidence is accumulating that significant WL (>10%) may reduce this risk. GDF15 is a secreted circulating polypeptide associated with energy balance. The receptor for G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057b147e1a40500b6de1db0eb968f449
https://doi.org/10.1210/js.2019-mon-lb020

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MON-109 Identifying Limiting Factors to Weight Loss and Prevention of Comorbidities in a Patient Population with Obesity

Autor: Amy H. Warriner, Allison Johns

Publikováno v: Journal of the Endocrine Society

Introduction: Obesity is a disease affecting 1/3of our patients and is accompanied by numerous comorbidities, including pre-diabetes (preDM) and diabetes (DM). Cause of obesity is often multifactorialwith biochemical, genetic, and environmental facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f979150351cc05bb9c66b6bb5b98a5d3
http://europepmc.org/articles/PMC6550620

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MON-112 Gelesis100 Reduces Insulin Resistance in Patients Who Are Overweight or Have Obesity with High Insulin Resistance: Results of the GLOW Study

Publikováno v: Journal of the Endocrine Society

Background: Overweight and obesity are predisposing conditions for the development of prediabetes and type 2 diabetes. Insulin resistance caused by excess adiposity is a key factor in this process. Methods: The effect of Gelesis100, a novel hydrogel,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d94cd5fb62a9fd65f6ab86c91bb2e21
http://europepmc.org/articles/PMC6550777

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MON-113 Taste Sensitivity is Related to Incretin Response to Oral Glucose Challenge, Dietary Habits and Body Composition: A Novel Link with Energy Metabolism

Autor: Cem Simsek, Ugur Unluturk, Selcuk Dagdelen, Seyma Avci, Busra Firlatan, Tomris Erbas, Taha Solakoglu, Aylin Acikgoz, Incilay Lay

Publikováno v: Journal of the Endocrine Society

Introduction: The effects of interindividual variability of taste sensitivity on energy metabolism is not yet known. We have studied the effect of taste sensitivities on dietary habits, body composition, and incretin responses to the oral glucose cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55abc074a5890e43099576e4f8b036f4
http://europepmc.org/articles/PMC6551011

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MON-110 A Natural Compound Isolated from Schisandra Chinensis Fruit Has a Beneficial Effect in a Fly Model of Obesity

Autor: Chong Kun Cheon, Lee Joo Young

Publikováno v: Journal of the Endocrine Society

Objectives: Gomisin N is a lignin derived from Schisandra chinensis that was reported to exhibit hepato-protective, anticancer, and anti-inflammatory effects. However, its role in whole body energetic homeostasis remains unclear. Drosophila melanogas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca68624a45f6f095bd9f7cb15fe338a
http://europepmc.org/articles/PMC6550590

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MON-107 Endothelium Derived Factors Influence Differentiation of Fat Derived Stromal Cells

Autor: Sabyasachi Sen, Peter Kokkinos, Eric S. Nylen, Cleyton C. Domingues, Nabanita Kundu

Publikováno v: Journal of the Endocrine Society

By 2030, the prevalence of diabetes will rise by 54% and will become a global epidemic. Aerobic exercise is known to show positive effects on cardiovascular health in diabetes and pre-diabetes subjects. However, the effect of exercise on vascular hea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ac678ee66fd90e5508717efd649900
http://europepmc.org/articles/PMC6550666

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