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Nascent RHOH acts as a molecular brake on actomyosin-mediated effector functions of inflammatory neutrophils

Autor: Peng, Shuang, Stojkov, Darko, Gao, Jian, Oberson, Kevin, Latzin, Philipp, Casaulta, Carmen, Yousefi, Shida, Simon, Hans-Uwe

Publikováno v: Peng, Shuang; Stojkov, Darko; Gao, Jian; Oberson, Kevin; Latzin, Philipp; Casaulta, Carmen; Yousefi, Shida; Simon, Hans-Uwe (2022). Nascent RHOH acts as a molecular brake on actomyosin-mediated effector functions of inflammatory neutrophils. PLoS biology, 20(9), e3001794. Public Library of Science 10.1371/journal.pbio.3001794

In contrast to molecular changes associated with increased inflammatory responses, little is known about intracellular counter-regulatory mechanisms that control signaling cascades associated with functional responses of neutrophils. Active RHO GTPas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d19ef783f283fc2b60842bade1c9958
https://boris.unibe.ch/173048/1/journal.pbio.3001794.pdf

ACSL3-PAI-1 signaling axis mediates tumor-stroma cross-talk promoting pancreatic cancer progression

Autor: Rossi Sebastiano, Matteo, Pozzato, Chiara, Saliakoura, Maria, Zhang, Yang, Peng, Ren-Wang, Galiè, Mirco, Oberson, Kevin, Simon, Hans-Uwe, Karamitopoulou, Evanthia, Konstantinidou, Georgia

Publikováno v: Science Advances
Rossi Sebastiano, Matteo; Pozzato, Chiara; Saliakoura, Maria; Zhang, Yang; Peng, Ren-Wang; Galiè, Mirco; Oberson, Kevin; Simon, Hans-Uwe; Karamitopoulou, Evanthia; Konstantinidou, Georgia (2020). ACSL3-PAI-1 signaling axis mediates tumor-stroma cross-talk promoting pancreatic cancer progression. Science Advances, 6(44), pp. 1-15. American Association for the Advancement of Science 10.1126/sciadv.abb9200

Pharmacological inhibition of PAI-1 strongly enhances chemo- and immunotherapeutic response against PDAC.
Pancreatic ductal adenocarcinoma (PDAC) is characterized by marked fibrosis and low immunogenicity, features that are linked to treatment r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1227856ad850be2fa96d19db4c047390

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