Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Obdulia, Rabal"'
Autor:
Edurne San José-Enériz, Naroa Gimenez-Camino, Obdulia Rabal, Leire Garate, Estibaliz Miranda, Nahia Gómez-Echarte, Fernando García, Stella Charalampopoulou, Elena Sáez, Amaia Vilas-Zornoza, Patxi San Martín-Uriz, Luis V. Valcárcel, Naroa Barrena, Diego Alignani, Luis Esteban Tamariz-Amador, Ana Pérez-Ruiz, Sebastian Hilscher, Mike Schutkowski, Ana Alfonso-Pierola, Nicolás Martinez-Calle, María José Larrayoz, Bruno Paiva, María José Calasanz, Javier Muñoz, Marta Isasa, José Ignacio Martin-Subero, Antonio Pineda-Lucena, Julen Oyarzabal, Xabier Agirre, Felipe Prósper
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Despite the development of novel therapies for acute myeloid leukemia, outcomes remain poor for most patients, and therapeutic improvements are an urgent unmet need. Although treatment regimens promoting differentiation have succeeded in the
Externí odkaz:
https://doaj.org/article/c19f4277205c445384d53303bce19ff2
Autor:
Couturier, Cédric, Ronzon, Quentin, Lattanzi, Giulia, Lingard, Iain, Coyne, Sebastien, Cazals, Veronique, Dubarry, Nelly, Yvon, Stephane, Leroi-Geissler, Corinne, Gracia, Obdulia Rabal, Teague, Joanne, Sordello, Sylvie, Corbett, David, Bauch, Caroline, Monlong, Chantal, Payne, Lloyd, Taillier, Thomas, Fuchs, Hazel, Broenstrup, Mark, Harrison, Peter H., Moynié, Lucile, Lakshminarayanan, Abirami, Gianga, Tiberiu-Marius, Hussain, Rohanah, Naismith, James H., Mourez, Michael, Bacqué, Eric, Björkling, Fredrik, Sabuco, Jean-Francois, Franzyk, Henrik
Publikováno v:
In European Journal of Medicinal Chemistry 5 February 2024 265
Akademický článek
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Publikováno v:
Journal of Cheminformatics, Vol 10, Iss 1, Pp 1-19 (2018)
Abstract Epigenetic therapies are being investigated for the treatment of cancer, cognitive disorders, metabolic alterations and autoinmune diseases. Among the different epigenetic target families, protein lysine methyltransferases (PKMTs), are espec
Externí odkaz:
https://doaj.org/article/7fc2e2566987484cbf22e578a7ad0e5d
Autor:
Edurne San José-Enériz, Xabier Agirre, Obdulia Rabal, Amaia Vilas-Zornoza, Juan A. Sanchez-Arias, Estibaliz Miranda, Ana Ugarte, Sergio Roa, Bruno Paiva, Ander Estella-Hermoso de Mendoza, Rosa María Alvarez, Noelia Casares, Victor Segura, José I. Martín-Subero, François-Xavier Ogi, Pierre Soule, Clara M. Santiveri, Ramón Campos-Olivas, Giancarlo Castellano, Maite Garcia Fernandez de Barrena, Juan Roberto Rodriguez-Madoz, Maria José García-Barchino, Juan Jose Lasarte, Matias A Avila, Jose Angel Martinez-Climent, Julen Oyarzabal, Felipe Prosper
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Epigenetic drugs are emerging as a powerful therapeutic option for cancer treatment. Here, the authors synthesized selective chemical probes that simultaneously inhibit the G9a and DNMTs methyltransferase activity and demonstrate their anti-tumour ac
Externí odkaz:
https://doaj.org/article/286f3156e84448249eb1c05f274be064
Autor:
Mar Cuadrado-Tejedor, Marta Pérez-González, Cristina García-Muñoz, Damián Muruzabal, Carolina García-Barroso, Obdulia Rabal, Víctor Segura, Juan A. Sánchez-Arias, Julen Oyarzabal, Ana Garcia-Osta
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
The discouraging results with therapies for Alzheimer’s disease (AD) in clinical trials, highlights the urgent need to adopt new approaches. Like other complex diseases, it is becoming clear that AD therapies should focus on the simultaneous modula
Externí odkaz:
https://doaj.org/article/406af94d56d34149a280e4d9333bb21a
Autor:
Edurne San José-Enériz, Naroa Gimenez-Camino, Obdulia Rabal, Leire Garate, Estibaliz Miranda, Fernando García, Elena Sáez, Amaia Amaia Vilas-Zornoza, Patxi San Martín-Uriz, Luis V. Valcárcel, Esteban Tamariz-Amador, Ana Alfonso-Pierola, Nicolás Martinez-Calle, María Larráyoz, Maria-Jose Calasanz, Javier Muñoz, Jose Ignacio Martin-Subero, Antonio Pineda, Julen Oyarzabal, Xabier Agirre, Felipe Prosper
Despite the development of novel therapies for acute myeloid leukemia (AML), outcomes remain poor for most patients, and therapeutic improvements are an urgent unmet need. Although treatment regimens promoting differentiation have succeeded in the tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11053b1482ffc59c4ff28126ed0dcbed
https://doi.org/10.21203/rs.3.rs-2441914/v1
https://doi.org/10.21203/rs.3.rs-2441914/v1
Autor:
Jon Celay, Teresa Lozano, Axel R. Concepcion, Elena Beltrán, Francesc Rudilla, María José García-Barchino, Eloy F. Robles, Obdulia Rabal, Irene de Miguel, Carlos Panizo, Noelia Casares, Julen Oyarzabal, Jesús Prieto, Juan F. Medina, Juan José Lasarte, José Ángel Martínez-Climent
Publikováno v:
Haematologica, Vol 103, Iss 6 (2018)
Regulatory T (Treg) cells can weaken antitumor immune responses, and inhibition of their function appears to be a promising therapeutic approach in cancer patients. Mice with targeted deletion of the gene encoding the Cl−/HCO3− anion exchanger AE
Externí odkaz:
https://doaj.org/article/25a1ce682baf49a699ef7d52c130573e
Autor:
Aritz Lasarte-Cia, Teresa Lozano, Marta Pérez-González, Marta Gorraiz, Kristina Iribarren, Sandra Hervás-Stubbs, Pablo Sarobe, Obdulia Rabal, Mar Cuadrado-Tejedor, Ana García-Osta, Noelia Casares, Juan José Lasarte
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
A complex network of interactions exists between the immune, the olfactory, and the central nervous system (CNS). Inhalation of different fragrances can affect immunological reactions in response to an antigen but also may have effects on the CNS and
Externí odkaz:
https://doaj.org/article/73a46b8c747b499db086afefbdededc1
Publikováno v:
Journal of Computer-Aided Molecular Design. 35:1195-1206
Structure-based virtual screening plays a significant role in drug-discovery. The method virtually docks millions of compounds from corporate or public libraries into a binding site of a disease-related protein structure, allowing for the selection o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313050ae92eda0ccaccd52439f831708
https://doi.org/10.1007/s10822-021-00431-4
https://doi.org/10.1007/s10822-021-00431-4