Zobrazeno 1 - 10
of 640
pro vyhledávání: '"Obatoclax"'
Autor:
Binli Mao, Vu Thuy Khanh Le-Trilling, Kai Wang, Denise Mennerich, Jie Hu, Zhenyu Zhao, Jiaxin Zheng, Yingying Deng, Benjamin Katschinski, Shilei Xu, Guiji Zhang, Xuefei Cai, Yuan Hu, Jianwei Wang, Mengji Lu, Ailong Huang, Ni Tang, Mirko Trilling, Yong Lin
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 483-497 (2022)
Coronavirus disease 2019 (COVID-19) caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has set off a global pandemic. There is an urgent unmet need for safe, affordable, and effective therapeutics against COVID-19. In
Externí odkaz:
https://doaj.org/article/2cc623b759fd4f6bbe6c4382c628268d
Autor:
Margarita Espona-Fiedler, Pilar Manuel-Manresa, Cristina Benítez-García, Pere Fontova, Roberto Quesada, Vanessa Soto-Cerrato, Ricardo Pérez-Tomás
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 97 (2022)
Metastasis is the primary cause of death in cancer patients. Many current chemotherapeutic agents only show cytotoxic, but not antimetastatic properties. This leads to a reduction in tumor size, but allows cancer cells to disseminate, which ultimatel
Externí odkaz:
https://doaj.org/article/fdb43ea166df4a6d8d5110b13090a1b5
Publikováno v:
Translational Oncology, Vol 14, Iss 8, Pp 101116- (2021)
Bcl-2 family proteins play critical roles in regulating lymphocyte development and maintain homeostasis, and have also been proved to be involved in various cancer types development. However, the role of Bcl-2 in hepatocellular carcinoma (HCC) develo
Externí odkaz:
https://doaj.org/article/940142f8de4f4e6d904f0d76388170b0
Autor:
Bernd Kubista, Thomas Schoefl, Lisa Mayr, Sushilla van Schoonhoven, Petra Heffeter, Reinhard Windhager, Bernhard K. Keppler, Walter Berger
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 36, Iss 1, Pp 1-13 (2017)
Abstract Background Osteosarcoma is the most frequent primary malignant bone tumor. Although survival has distinctly increased due to neoadjuvant chemotherapy in the past, patients with metastatic disease and poor response to chemotherapy still have
Externí odkaz:
https://doaj.org/article/572afccbcf204f4ba0e2b876faa027d7
Akademický článek
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Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 705 (2021)
The aim of this work was to explore new therapeutic options against Chagas disease by the in vitro analysis of the biocidal activities of several tambjamine and prodiginine derivatives, against the Trypanosoma cruzi CLB strain (DTU TcVI). The compoun
Externí odkaz:
https://doaj.org/article/dd65907d794b4f5d8127112ba7a14ba1
Akademický článek
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Akademický článek
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Autor:
Lorena Lobo de Figueiredo-Pontes, Hisashi Takei, Ann Mullally, Yuta Mishima, Keli Lima, Ikei S. Kobayashi, Adriana Queiroz Arantes Rocha, Thiago Mantello Bianco, Susumu Kobayashi, João Agostinho Machado-Neto, Cristina Tavares Leal, Robert S. Welner, Juan L Coelho-Silva
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Several lines of research suggest that BCL-XL-mediated anti-apoptotic effects may contribute to pathogenesis of myeloproliferative neoplasms driven by JAK2V617F and serve as therapeutic target. Here, we used a knock-in JAK2V617F mouse model and confi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1853da5e3b8fa7cbc43125a9e0fb84e9
https://doi.org/10.1111/cas.15210
https://doi.org/10.1111/cas.15210
Publikováno v:
Journal of Immunology Research, Vol 2021 (2021)
Journal of Immunology Research
Journal of Immunology Research
Background. Bladder cancer is the tenth most common cancer worldwide. Valuable biomarkers in the field of diagnostic bladder cancer are urgently required. Method. Here, the gene expression matrix and clinical data were obtained from The Cancer Genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc6f428047ba3d32eca82c9a6842fa4
https://doi.org/10.1155/2021/3236384
https://doi.org/10.1155/2021/3236384