Structural transitions modulate the chaperone activities of Grp94.

Autor: Amankwah YS; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056.; Pelotonia Institute for Immuno-Oncology, Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Columbus, OH 43210., Fleifil Y; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056., Unruh E; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056.; Cell, Molecular, and Structural Biology Graduate Program, Miami University, Oxford, OH 45056., Collins P; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056., Wang Y; Pelotonia Institute for Immuno-Oncology, Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Columbus, OH 43210., Vitou K; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056., Bates A; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056., Obaseki I; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056., Sugoor M; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056., Alao JP; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056., McCarrick RM; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056., Gewirth DT; Hauptman-Woodward Medical Research Institute, Buffalo, NY 14203., Sahu ID; Natural Sciences Division, Campbellsville University, Campbellsville, KY 42718., Li Z; Pelotonia Institute for Immuno-Oncology, Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Columbus, OH 43210., Lorigan GA; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056.; Cell, Molecular, and Structural Biology Graduate Program, Miami University, Oxford, OH 45056., Kravats AN; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056.; Cell, Molecular, and Structural Biology Graduate Program, Miami University, Oxford, OH 45056.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Mar 19; Vol. 121 (12), pp. e2309326121. Date of Electronic Publication: 2024 Mar 14.

J-domain Proteins form Binary Complexes with Hsp90 and Ternary Complexes with Hsp90 and Hsp70.

Autor: Wickramaratne AC; Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Liao JY; Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Doyle SM; Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Hoskins JR; Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Puller G; Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Scott ML; Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Alao JP; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA., Obaseki I; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA., Dinan JC; Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Maity TK; Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Jenkins LM; Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Kravats AN; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA. Electronic address: kravatan@MiamiOH.edu., Wickner S; Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: wickners@mail.nih.gov.

Publikováno v: Journal of molecular biology [J Mol Biol] 2023 Sep 01; Vol. 435 (17), pp. 168184. Date of Electronic Publication: 2023 Jun 20.

Discovery of new promising USP14 inhibitors: computational evaluation of the thumb-palm pocket.

Autor: Adelakun N; Chemogenomics Unit, Department of Biochemistry, Adekunle Ajasin University, Akungba-Akoko, Nigeria.; Department of Biochemistry, Adekunle Ajasin University, Akungba-Akoko, Nigeria., Obaseki I; Department of Biochemistry, Bells University of Technology, Ota, Nigeria., Adeniyi A; Chemogenomics Unit, Department of Biochemistry, Adekunle Ajasin University, Akungba-Akoko, Nigeria.; Department of Biochemistry, Adekunle Ajasin University, Akungba-Akoko, Nigeria., Fapohunda O; Department of Biochemistry, Adekunle Ajasin University, Akungba-Akoko, Nigeria., Obaseki E; Department of Plant Science and Biotechnology, University of Benin, Benin City, Nigeria., Omotuyi O; Chemogenomics Unit, Department of Biochemistry, Adekunle Ajasin University, Akungba-Akoko, Nigeria.; Department of Biochemistry, Adekunle Ajasin University, Akungba-Akoko, Nigeria.

Publikováno v: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2022 Apr; Vol. 40 (7), pp. 3060-3070. Date of Electronic Publication: 2020 Nov 10.

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DUBs in Alzheimer's disease: mechanisms and therapeutic implications.

Autor: Qin, Biying, Chen, Xiaodong, Wang, Feng, Wang, Yanfeng

Publikováno v: Cell Death Discovery; 11/20/2024, Vol. 10 Issue 1, p1-15, 15p