Výsledky vyhledávání - "Obaid U, Khurram"

Akademický článek

Brain derived neurotrophic factor/tropomyosin related kinase B signaling impacts diaphragm neuromuscular transmission in a novel rat chemogenetic model

Autor: Matthew J. Fogarty, Obaid U. Khurram, Carlos B. Mantilla, Gary C. Sieck

Publikováno v: Frontiers in Cellular Neuroscience, Vol 16 (2022)

The neuromuscular junction (NMJ) mediates neural control of skeletal muscle fibers. Neurotrophic signaling, specifically brain derived neurotrophic factor (BDNF) acting through its high-affinity tropomyosin related kinase B (TrkB) receptor is known t

Externí odkaz: https://doaj.org/article/e32bda53bc914dac943bbdf4645eb6ac

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A geometric approach to quantifying the neuromodulatory effects of persistent inward currents on single motor unit discharge patterns

Autor: James. A. Beauchamp, Gregory E. P. Pearcey, Obaid U. Khurram, Matthieu Chardon, Curtis Wang, Randall K. Powers, Julius P.A. Dewald, CJ. Heckman

ObjectiveAll motor commands flow through motoneurons, which entrain control of their innervated muscle fibers, forming a motor unit (MU). Owing to the high fidelity of action potentials within MUs, their discharge profiles detail the organization of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6145380b6cc1eb7e44c677d5c7812a58
https://doi.org/10.1101/2022.10.06.511149

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The Cellular Basis for the Generation of Firing Patterns in Human Motor Units

Autor: Obaid U, Khurram, Gregory E P, Pearcey, Matthieu K, Chardon, Edward H, Kim, Marta, García, C J, Heckman

Publikováno v: Advances in neurobiology. 28

Motor units, which comprise a motoneuron and the set of muscle fibers it innervates, are the fundamental neuromuscular transducers for all motor commands. The one to one relationship between a motoneuron and its innervated muscle fibers allow motoneu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e324662ba7c87f2b0ef5456aaffb116e
https://pubmed.ncbi.nlm.nih.gov/36066828

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Antagonist tendon vibration dampens estimates of persistent inward currents in motor units of the human lower limb

Autor: Gregory E P Pearcey, Obaid U Khurram, James A Beauchamp, Francesco Negro, Charles J Heckman

We can readily measure motoneuron discharge patterns in humans due to the one-to-one spike relation between motoneuron and muscle fiber action potentials, which allows us to make inferences about motor commands. Persistent inward currents (PICs), whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0516f67f3026ad763aeb378b421fb24c
https://doi.org/10.1101/2022.08.02.502526

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Estimates of persistent inward currents in tibialis anterior motor units during standing ramped contraction tasks in humans

Autor: Francesco Negro, Charles J. Heckman, Christopher K. Thompson, Obaid U. Khurram

Publikováno v: J Neurophysiol

Persistent inward currents (PICs) play an essential role in setting motor neuron gain and shaping motor unit firing patterns. Estimates of PICs in humans can be made using the paired motor unit analysis technique, which quantifies the difference in d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0896051d37869475f371aef7bc97f90
https://doi.org/10.1152/jn.00144.2021

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A geometric approach to quantifying the neuromodulatory effects of persistent inward currents on individual motor unit discharge patterns

Autor: James A Beauchamp, Gregory E P Pearcey, Obaid U Khurram, Matthieu Chardon, Y Curtis Wang, Randall K Powers, Julius P A Dewald, CJ Heckman

Publikováno v: Journal of Neural Engineering. 20:016034

Objective. All motor commands flow through motoneurons, which entrain control of their innervated muscle fibers, forming a motor unit (MU). Owing to the high fidelity of action potentials within MUs, their discharge profiles detail the organization o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bbf6565959e9a572246a2dfc853ad12c
https://doi.org/10.1088/1741-2552/acb1d7

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A computational approach for generating continuous estimates of motor unit discharge rates and visualizing population discharge characteristics

Autor: James A Beauchamp, Obaid U Khurram, Julius P A Dewald, CJ Heckman, Gregory E P Pearcey

Publikováno v: Journal of neural engineering. 19(1)

Objective. Successive improvements in high density surface electromyography and decomposition techniques have facilitated an increasing yield in decomposed motor unit (MU) spike times. Though these advancements enhance the generalizability of finding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9ba3ac5ed067b8faa54cc15cfc3835
https://pubmed.ncbi.nlm.nih.gov/34937005

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