Výsledky vyhledávání - "Obada A, Sibai"

QSAR, structure-based pharmacophore modelling and biological evaluation of novel platelet ADP receptor (P2Y12) antagonist

Autor: Belal O. Al-Najjar, Manal A. Abbas, Obada A. Sibai, Fadi G. Saqallah, Aya Y. Al-Kabariti

Publikováno v: RSC Medicinal Chemistry. 14:239-246

In silico and in vitro discovery of P2Y12 antagonists utilizing structure-based pharmacophore modelling directed by quantitative structure-activity relationship (QSAR) analysis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac7c6f918e675d05408cf9ddc531a5bf
https://doi.org/10.1039/d2md00285j

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P2Y

Autor: Belal O, Al-Najjar, Fadi G, Saqallah, Manal A, Abbas, Serena Z, Al-Hijazeen, Obada A, Sibai

Publikováno v: European journal of medicinal chemistry. 227

P2Y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c4df53955c2d078ccc83fcacd8da5e58
https://pubmed.ncbi.nlm.nih.gov/34731765

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P2Y12 antagonists: Approved drugs, potential naturally isolated and synthesised compounds, and related in-silico studies

Autor: Obada A. Sibai, Fadi G Saqallah, Serena Z. Al-Hijazeen, Manal A. Abbas, Belal O. Al-Najjar

Publikováno v: European Journal of Medicinal Chemistry. 227:113924

P2Y12 is a platelet surface protein which is responsible for the amplification of P2Y1 response. It plays a crucial role in platelet aggregation and thrombus formation through an ADP-induced platelet activation mechanism. Despite that P2Y12 platelets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e968694d70c79df8a9f64541243ee18
https://doi.org/10.1016/j.ejmech.2021.113924

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