Comprehensive stable-isotope tracing of glucose and amino acids identifies metabolic by-products and their sources in CHO cell culture.

Autor: Gonzalez JE; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716., Naik HM; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218., Oates EH; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716., Dhara VG; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218., McConnell BO; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716., Kumar S; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218., Betenbaugh MJ; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218., Antoniewicz MR; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716.; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Oct 08; Vol. 121 (41), pp. e2403033121. Date of Electronic Publication: 2024 Oct 04.

Coordinated reprogramming of metabolism and cell function in adipocytes from proliferation to differentiation.

Autor: Oates EH; Department of Chemical and Biomolecular Engineering, Metabolic Engineering and Systems Biology Laboratory, University of Delaware, Newark, DE, 19716, USA., Antoniewicz MR; Department of Chemical and Biomolecular Engineering, Metabolic Engineering and Systems Biology Laboratory, University of Delaware, Newark, DE, 19716, USA. Electronic address: mranton@udel.edu.

Publikováno v: Metabolic engineering [Metab Eng] 2022 Jan; Vol. 69, pp. 221-230. Date of Electronic Publication: 2021 Dec 17.