Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Oana Ursu"'
Autor:
Oana URSU, Elena CIORTESCU
Publikováno v:
CES Working Papers, Vol XIII, Iss 2, Pp 149-158 (2021)
This paper starts from the assumption that in our current world, dominated by fast-paced changes, culture has acquired increasing prominence, which is likely to affect interpersonal and business relationships alike. Therefore, relying on a number o
Externí odkaz:
https://doaj.org/article/7b32f19ed8104d74abb95444a6965112
Autor:
Josh Tycko, Michael Wainberg, Georgi K. Marinov, Oana Ursu, Gaelen T. Hess, Braeden K. Ego, Aradhana, Amy Li, Alisa Truong, Alexandro E. Trevino, Kaitlyn Spees, David Yao, Irene M. Kaplow, Peyton G. Greenside, David W. Morgens, Douglas H. Phanstiel, Michael P. Snyder, Lacramioara Bintu, William J. Greenleaf, Anshul Kundaje, Michael C. Bassik
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Off-target effects in CRISPR screens for essential regulatory elements have not been systematically evaluated. Here the authors find Cas9 nuclease, CRISPRi/a each have distinct off-target effects, and that these can be accurately identified and remov
Externí odkaz:
https://doaj.org/article/fc5611c303ab470e9fff314f00d1301c
Autor:
Galip Gürkan Yardımcı, Hakan Ozadam, Michael E. G. Sauria, Oana Ursu, Koon-Kiu Yan, Tao Yang, Abhijit Chakraborty, Arya Kaul, Bryan R. Lajoie, Fan Song, Ye Zhan, Ferhat Ay, Mark Gerstein, Anshul Kundaje, Qunhua Li, James Taylor, Feng Yue, Job Dekker, William S. Noble
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-19 (2019)
Abstract Background Hi-C is currently the most widely used assay to investigate the 3D organization of the genome and to study its role in gene regulation, DNA replication, and disease. However, Hi-C experiments are costly to perform and involve mult
Externí odkaz:
https://doaj.org/article/c5c3304bc21c457993be8f6384642f01
Autor:
David W. Morgens, Michael Wainberg, Evan A. Boyle, Oana Ursu, Carlos L. Araya, C. Kimberly Tsui, Michael S. Haney, Gaelen T. Hess, Kyuho Han, Edwin E. Jeng, Amy Li, Michael P. Snyder, William J. Greenleaf, Anshul Kundaje, Michael C. Bassik
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
CRISPR-Cas9 screens are powerful high-throughput tools but can be confounded by nuclease toxicity. Here the authors design a library of variable length gRNAs with thousands of negative controls, including the targeting of ‘safe’ loci to account f
Externí odkaz:
https://doaj.org/article/da97c345b50241ee96636d0cb1d3e3fc
Network modeling of kinase inhibitor polypharmacology reveals pathways targeted in chemical screens.
Autor:
Oana Ursu, Sara J C Gosline, Neil Beeharry, Lauren Fink, Vikram Bhattacharjee, Shao-Shan Carol Huang, Yan Zhou, Tim Yen, Ernest Fraenkel
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185650 (2017)
Small molecule screens are widely used to prioritize pharmaceutical development. However, determining the pathways targeted by these molecules is challenging, since the compounds are often promiscuous. We present a network strategy that takes into ac
Externí odkaz:
https://doaj.org/article/c5dacd65383e474d8521872df90c9ffa
Autor:
Jordan E. Otto, Oana Ursu, Alexander P. Wu, Evan B. Winter, Michael S. Cuoco, Sai Ma, Kristin Qian, Brittany C. Michel, Jason D. Buenrostro, Bonnie Berger, Aviv Regev, Cigall Kadoch
Publikováno v:
Molecular Cell. 83:1350-1367.e7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c50ee04cd0e8847e9a3673776fa9eea4
https://doi.org/10.1016/j.molcel.2023.03.013
https://doi.org/10.1016/j.molcel.2023.03.013
Autor:
Oana Ursu
Publikováno v:
Virgil Madgearu Review of Economic Studies and Research. 13:223-234
Considering the present-day international context, with the increasing workforce mobility and the global exchange of knowledge and best practices, most companies expect their workers to be able to communicate effectively across cultures. Thus, since
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a5f7452c664150b0fbb71e73ae8f3bc
https://doi.org/10.24193/rvm.2020.13.69
https://doi.org/10.24193/rvm.2020.13.69
Autor:
Oana Ursu, James T. Neal, Emily Shea, Pratiksha I. Thakore, Livnat Jerby-Arnon, Lan Nguyen, Danielle Dionne, Celeste Diaz, Julia Bauman, Mariam Mounir Mosaad, Christian Fagre, April Lo, Maria McSharry, Andrew O. Giacomelli, Seav Huong Ly, Orit Rozenblatt-Rosen, William C. Hahn, Andrew J. Aguirre, Alice H. Berger, Aviv Regev, Jesse S. Boehm
Publikováno v:
Nature Biotechnology. 40:1691-1691
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0406621b477fae1ad8d1cbdbf885db05
https://doi.org/10.1038/s41587-022-01495-9
https://doi.org/10.1038/s41587-022-01495-9
Autor:
Andrew O. Giacomelli, William C. Hahn, Julia Bauman, Orit Rozenblatt-Rosen, Andrew J. Aguirre, Lan Nguyen, Jesse S. Boehm, Emily K Shea, Seav Huong Ly, Pratiksha I. Thakore, Danielle Dionne, Alice H. Berger, Celeste Diaz, James T. Neal, Livnat Jerby-Arnon, Christian R. Fagre, Aviv Regev, Mariam Mounir Mosaad, Oana Ursu
Genome sequencing studies have identified millions of somatic variants in cancer, but their phenotypic impact remains challenging to predict. Current experimental approaches to distinguish between functionally impactful and neutral variants require c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f573fe66aaf4affc6af462a900eb606
https://doi.org/10.1101/2020.11.16.383307
https://doi.org/10.1101/2020.11.16.383307
Autor:
Oana Ursu, James T. Neal, Emily Shea, Pratiksha I. Thakore, Livnat Jerby-Arnon, Lan Nguyen, Danielle Dionne, Celeste Diaz, Julia Bauman, Mariam Mounir Mosaad, Christian Fagre, April Lo, Maria McSharry, Andrew O. Giacomelli, Seav Huong Ly, Orit Rozenblatt-Rosen, William C. Hahn, Andrew J. Aguirre, Alice H. Berger, Aviv Regev, Jesse S. Boehm
Publikováno v:
Nature biotechnology. 40(6)
Genome sequencing studies have identified millions of somatic variants in cancer, but it remains challenging to predict the phenotypic impact of most. Experimental approaches to distinguish impactful variants often use phenotypic assays that report o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ffdca11c4d9677f56b8d32a075c2ad
https://pubmed.ncbi.nlm.nih.gov/36258042
https://pubmed.ncbi.nlm.nih.gov/36258042