Výsledky vyhledávání - "Oana Florean"

Semi-automated approach for generation of biological networks on drug-induced cholestasis, steatosis, hepatitis, and cirrhosis

Autor: Hyun Kil Shin, Oana Florean, Barry Hardy, Tatyana Doktorova, Myung-Gyun Kang

Publikováno v: Toxicological Research. 38:393-407

Drug-induced liver injury (DILI) is one of the leading reasons for discontinuation of a new drug development project. Diverse machine learning or deep learning models have been developed to predict DILI. However, these models have not provided an ade

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b9f4aa1db5b52c41376d71d717a13fd
https://doi.org/10.1007/s43188-022-00124-6

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Integrated analysis of in vitro data and the adverse outcome pathway framework for prioritization and regulatory applications: An exploratory case study using publicly available data on piperonyl butoxide and liver models

Autor: Thomas Exner, Oana Florean, Lucian Farcal, Pekka Kohonen, Barry Hardy, Roland C. Grafström, Noffisat O. Oki, Ahmed Abdelaziz, Tatyana Y. Doktorova

Publikováno v: Toxicology in Vitro

The integration of existing knowledge to support the risk assessment of chemicals is an ongoing challenge for scientists, risk assessors and risk managers. In addition, European Union regulations limiting the use of new animal testing in cosmetics ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f49bc8a272b3d521216d935115f69bf9

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