Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Oak K. Kim"'
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:766-776
The Pseudomonas aeruginosa type III secretion system (T3SS) is a primary virulence determinant and a potential target for antivirulence drugs. One candidate target is ExsA, a member of the AraC family of DNA-binding proteins required for expression o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6badbfcc3f83bedd1e39fe2f5a780f41
https://doi.org/10.1128/aac.02242-15
https://doi.org/10.1128/aac.02242-15
Autor:
Mark Grier, Michael Draper, Caroline Dudley, Peter J. Donovan, Oak K. Kim, Kevin A. Klausner, Victoria J. Bartlett, S. Ken Tanaka, Michael N. Alekshun, Stuart B. Levy, Lynne Garrity-Ryan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3380-3383
ExsA is a multiple adaptational response (MAR) transcription factor, regulating the expression of a virulence determinant, the type III secretion system (T3SS) in Pseudomonas aeruginosa. Non-cytotoxic, non-antibacterial N-hydroxybenzimidazoles were i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8be65f7737be644a80b5d301b11471
https://doi.org/10.1016/j.bmcl.2010.04.014
https://doi.org/10.1016/j.bmcl.2010.04.014
Autor:
Michael N. Alekshun, Ann B. Macone, Atul K. Verma, S. Ken Tanaka, Mark Grier, Victoria J. Bartlett, Oak K. Kim, J. Donatelli, Lynne Garrity-Ryan, Stuart B. Levy, Gabriel Medjanis
Publikováno v:
Journal of Medicinal Chemistry. 52:5626-5634
LcrF, a Multiple Adaptational Response (MAR) transcription factor, regulates virulence in Yersinia pestis and Yersinia pseudotuberculosis. In a search for small molecule inhibitors of LcrF, an acrylic amide series of N-hydroxybenzimidazoles was synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18f4cd74e15c6fe85f519b47a59d6b9
https://doi.org/10.1021/jm9006577
https://doi.org/10.1021/jm9006577
Autor:
Carol Deminie, Timothy Johnson, Oak K. Kim, Andrew J. Staab, Zeyu Lin, Roger Remillard, Brian Terry, Nicholas A. Meanwell, Mark Krystal, Michael A. Walker, Albert Torri, Jacques Banville, Henry Wong, Himadri Samanta, Zhuping Ma, Yunhui Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2920-2924
Integrase is one of three enzymes expressed by HIV and represents a validated target for therapy. This study reports on the discovery of a new triketoacid-based chemotype that selectively inhibits the strand transfer reaction of HIV-integrase. SAR st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fd8b9d5313f5ff66df45302eb2a17b
https://doi.org/10.1016/j.bmcl.2006.03.010
https://doi.org/10.1016/j.bmcl.2006.03.010
Autor:
Wenying Li, Timothy P. Connolly, Yasutsugu Ueda, Oak K. Kim, B. Narasimhulu Naidu, John D. Matiskella, Kin Sing Lam, John A. Wichtowski, Joanne J. Bronson, Yunhui Zhang, Margaret E. Sorenson
Publikováno v:
Tetrahedron Letters. 45:1059-1063
Nocathiacins are densely functionalized cyclic thiazolyl peptide natural products with potent in vitro and in vivo antibacterial activity against a variety of gram-positive bacteria, including a number of multiple drug-resistant strains. Attempts to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a123e6127ee04ca876f6d958f6cb61a7
https://doi.org/10.1016/j.tetlet.2003.11.081
https://doi.org/10.1016/j.tetlet.2003.11.081
Autor:
Oak K. Kim, John D. Matiskella, B. Narasimhulu Naidu, Yasutsugu Ueda, Thomas W. Hudyma, Xiaofan Zheng, Alicia Regueiro-Ren, Margaret E. Sorenson, Joanne J. Bronson, Yunhui Zhang, Junius M. Clark, Timothy P. Connolly, Michael J. Pucci
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:171-175
Several semi-synthetic bis- and mono- O -alkyl nocathiacin derivatives were synthesized and evaluated for antibacterial activity. Mono- O -alkyl N -hydroxyindole analogues 3a – l were prepared by regioselective alkylation. Bis- O -alkyl nocathiacin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb563a9c502bfb899ce991c6ecd46b9f
https://doi.org/10.1016/j.bmcl.2003.09.061
https://doi.org/10.1016/j.bmcl.2003.09.061
Autor:
Oak K. Kim, Joan Fung-Tomc
Publikováno v:
Expert Opinion on Therapeutic Patents. 11:1267-1276
This review summarises patents claiming β-lactam antibacterials published from January 1999 to March 2001. The majority in the patents described in this review disclose chemistry and biological evaluation of novel cephalosporin and carbapenem deriva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1fd7cf75010174e102b06751d141c43
https://doi.org/10.1517/13543776.11.8.1267
https://doi.org/10.1517/13543776.11.8.1267
Autor:
John D. Dimarco, Shankar Swaminathan, Brian Burke, Thomas P. Kissick, Oak K. Kim, Bin Zheng, Janak Singh, Kenneth J. Natalie, Goodrich Jason, Juliya Livshits, Matthew A. Brown, John A. Grosso, Zhinong Gao, Michael J. Humora, Anthony P. Dutka, Peter Hans Ermann, David R. Kronenthal, Gerard A. Crispino, Richard H. Mueller, John A. Wichtowski, Jeffrey T. North, Joanne J. Bronson, Jack Z. Gougoutas, Yasutsugu Ueda, Dane M. Springer, Peter Schierling, Bing Yu Luh, James E. Heikes, Dau-Ming Hsieh, Anne J. Pullockaran, Bo Zhang, Robert K. Perrone, Mei C. Lai, and Theodor W. Denzel, Yunhui Zhang
Publikováno v:
Organic Process Research & Development. 4:488-497
A practical synthesis of the anti-methicillin resistant Staphylococcus aureus cephem (6R-trans)-E-7-[[[[2,5-dichloro-4-[3-[(carboxymethyl)amino]-3-oxo-1-propenyl]phenyl]-thio]-acetyl]amino]-4-[[(2-carboxy-8-oxo-5-thia-1-azabicyclo-[4.2.0]oct-2-en-3-y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::030fc232263c59de1340816a124920ab
https://doi.org/10.1021/op0002850
https://doi.org/10.1021/op0002850
Autor:
Joanne J. Bronson, Oak K. Kim, Thomas W. Hudyma, John D. Matiskella, Yasutsugu Ueda, Muzammil M. Mansuri
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2753-2758
A series of cephalosporins bearing C-3 quaternary ammonium groups were prepared and evaluated for their anti-MRSA activity. They exhibit good to excellent in vitro activity (MICs = 1−8 μg/mL) against MRSA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4ce7aef58b79a5877b1ad1db273cefb
https://doi.org/10.1016/s0960-894x(97)10078-6
https://doi.org/10.1016/s0960-894x(97)10078-6
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1945-1950
A series of cephalosporins bearing C-3 benzoyloxymethyl groups were prepared and evaluated for their anti-MRSA activity and plasma stability. They exhibit excellent in vitro activity (MIC = 0.06 ∼2 μg/mL) against MRSA and excellent stability in hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64ebaf8ac4057403267f93d787e4b48d
https://doi.org/10.1016/s0960-894x(97)00338-7
https://doi.org/10.1016/s0960-894x(97)00338-7